A method for cryopreservation and single nucleus RNA-sequencing of normal adult human interventricular septum heart tissue reveals cellular diversity and function

Autor: Amy Larson, Michael T. Chin

Publikováno v: BMC Medical Genomics, Vol 14, Iss 1, Pp 1-8 (2021)

Abstract Background Single cell sequencing of human heart tissue is technically challenging and methods to cryopreserve heart tissue for obtaining single cell information have not been standardized. Studies published to date have used varying methods

Externí odkaz: https://doaj.org/article/b840116fb2714bf6b30f11b100e8015f

Variant R94C in TNNT2‐Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction

Autor: Jordan E. Ezekian, Sarah R. Clippinger, Jaquelin M. Garcia, Qixin Yang, Susan Denfield, Aamir Jeewa, William J. Dreyer, Wenxin Zou, Yuxin Fan, Hugh D. Allen, Jeffrey J. Kim, Michael J. Greenberg, Andrew P. Landstrom

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 5 (2020)

Background Pediatric‐onset restrictive cardiomyopathy (RCM) is associated with high mortality, but underlying mechanisms of disease are under investigated. RCM‐associated diastolic dysfunction secondary to variants in TNNT2‐encoded cardiac trop

Externí odkaz: https://doaj.org/article/f428e6dbe3634146959aabc307e2c353

Metabolic Remodeling in the Pressure‐Loaded Right Ventricle: Shifts in Glucose and Fatty Acid Metabolism—A Systematic Review and Meta‐Analysis

Autor: Anne‐Marie C. Koop, Guido P. L. Bossers, Mark‐Jan Ploegstra, Quint A. J. Hagdorn, Rolf M. F. Berger, Herman H. W. Silljé, Beatrijs Bartelds

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 21 (2019)

Background Right ventricular (RV) failure because of chronic pressure load is an important determinant of outcome in pulmonary hypertension. Progression towards RV failure is characterized by diastolic dysfunction, fibrosis and metabolic dysregulatio

Externí odkaz: https://doaj.org/article/cbe97ece7971434b9af7d9df7a8c2354

Serine/Threonine‐Protein Kinase 3 Facilitates Myocardial Repair After Cardiac Injury Possibly Through the Glycogen Synthase Kinase‐3β/β‐Catenin Pathway

Autor: Ling-Feng Gu, Yi Fan, Feng Chen, Ya-Fei Li, Hao Wang, Zi-Mu Wang, Bing-Rui Chen, Rui Sun, Yong-Yue Wei, Jia-Teng Sun, Xuejiang Guo, Lian-Sheng Wang, Tongtong Yang, Yao Ma, Tiankai Shan, Chong Du, Liu Liu, Xiang-Qing Kong, Tian-Wen Wei

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)

Background The neonatal heart maintains its entire regeneration capacity within days after birth. Using quantitative phosphoproteomics technology, we identified that SGK3 (serine/threonine‐protein kinase 3) in the neonatal heart is highly expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cb08a1cacbdc01e575870addf41383
https://doi.org/10.1161/jaha.121.022802

Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation

Autor: Jordan S. Pober, Andrew P. Landstrom, Ienglam Lei, Paul C. Tang, Marilia Cascalho, Chen Yuqing Eugene, Richard M. Mortensen, Zhong Wang, Francis D. Pagani, Peter A. Ward, George Tellides, Hugo Y.-K. Lam, Wei Huang, Gorav Ailawadi, Jeffrey L. Platt

Publikováno v: Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Physiological Reports

Background Dysfunction and inflammation of hearts subjected to cold ischemic preservation may differ between left and right ventricles, suggesting distinct strategies for amelioration. Methods and Results Explanted murine hearts subjected to cold isc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3dbc5e6a0fb9640fc1f6fcce471956
https://doi.org/10.14814/phy2.15004