Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation

Autor: Mills, Richard, Taylor-Weiner, Hermes, Correia, Jorge C, Agudelo, Leandro Z, Allodi, Ilary, Kolonelou, Christina, Martinez-Redondo, Vicente, Ferreira, Duarte M S, Nichterwitz, Susanne, Comley, Laura H, Lundin, Vanessa, Hedlund, Eva, Ruas, Jorge L, Teixeira, Ana I

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 7, Iss, Pp 12-22 (2018)
Mills, R, Taylor-Weiner, H, Correia, J C, Agudelo, L Z, Allodi, I, Kolonelou, C, Martinez-Redondo, V, Ferreira, D M S, Nichterwitz, S, Comley, L H, Lundin, V, Hedlund, E, Ruas, J L & Teixeira, A I 2018, ' Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation ', Molecular Metabolism, vol. 7, pp. 12-22 . https://doi.org/10.1016/j.molmet.2017.11.001

Objective We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. Methods A microfluidic device was used to model endocrine signaling and NMJ formation between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac476b81e4499193a3e091b3b4c9acb3
http://europepmc.org/articles/PMC5784328

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

Autor: Fulvio Reggiori, Monica Dentice, Marcella Neri, Manuela Antonioli, M. Di Rienzo, Idil Orhon, Fabiola Ciccosanti, Alessandra Ferlini, Giuseppe Merla, F. Germani, Mauro Piacentini, Barbara Mandriani, H. Ding, Giulia Refolo, Muriel Mari, Maria Teresa Pellico, Marco Corazzari, Molly Kulesz-Martin, Carmela Fusco, Gian Maria Fimia, Yuangang Liu, Alessandra Romagnoli, R. De La Torre

Publikováno v: Science Advances, 5(5):8857. AMER ASSOC ADVANCEMENT SCIENCE
Di Rienzo, M, Antonioli, M, Fusco, C, Liu, Y, Mari, M, Orhon, I, Refolo, G, Germani, F, Corazzari, M, Romagnoli, A, Ciccosanti, F, Mandriani, B, Pellico, M T, De La Torre, R, Ding, H, Dentice, M, Neri, M, Ferlini, A, Reggiori, F, Kulesz-Martin, M, Piacentini, M, Merla, G & Fimia, G M 2019, ' Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains ', Science Advances, vol. 5, no. 5, pp. eaau8857 . https://doi.org/10.1126/sciadv.aau8857
Science Advances

Muscular dystrophy-associated mutations of TRIM32 impair ULK1-dependent autophagy response during muscle atrophy.
Optimal autophagic activity is crucial to maintain muscle integrity, with either reduced or excessive levels leading to specific my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc5e5ef1f7060187c8321286a480b01
https://research.rug.nl/en/publications/4b803b6d-cd0a-4b3a-afe8-faf8661628fd

A novel in vitro model for the assessment of postnatal myonuclear accretion

Autor: Ellis Gielen, Anita Kneppers, Luc J. C. van Loon, Chiel C. de Theije, Ramon C. J. Langen, Mark Corten, Annemie M. W. J. Schols, Lex B. Verdijk

Publikováno v: Skeletal Muscle, Vol 8, Iss 1, Pp 1-13 (2018)
Skeletal Muscle
Skeletal Muscle, 8:4. BioMed Central Ltd

Background Due to the post-mitotic nature of myonuclei, postnatal myogenesis is essential for skeletal muscle growth, repair, and regeneration. This process is facilitated by satellite cells through proliferation, differentiation, and subsequent fusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87156d3fc968b0798d2685a4c5e60989
https://acuresearchbank.acu.edu.au/item/8845w/a-novel-in-vitro-model-for-the-assessment-of-postnatal-myonuclear-accretion

Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation

Autor: Etienne Lefai, Audrey Jalabert, Hubert Vidal, Sophie Rome, Sandra Pesenti, Karim Chikh, Elizabeth Errazuriz, Vanessa Euthine, Alexis Forterre, Aurélie Granjon

Publikováno v: Cell Cycle
Cell Cycle, Taylor & Francis, 2014, 13 (1), pp.78-89. ⟨10.4161/cc.26808⟩

International audience; It has recently been established that exosomes can mediate intercellular cross-talk under normal and pathological conditions through the transfer of specific miRNAs. As muscle cells secrete exosomes, we addressed the question

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f61dcbd55115e5c8f9b6ccb829164c5
https://hal.archives-ouvertes.fr/hal-01859385

Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

Autor: Bernd Bohrmann, Erhard Kopetzki, Christoph Schweitzer, Patrick Aebischer, Helmut Jacobsen, Bernard L. Schneider, Aurélien Lathuilière, Marc Moniatte

Publikováno v: Biomaterials, Vol. 35, No 2 (2014) pp. 792-802

The controlled delivery of antibodies by immunoisolated bioimplants containing genetically engineered cells is an attractive and safe approach for chronic treatments. To reach therapeutic antibody levels there is a need to generate renewable cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c9d608cfaa724edd5140b58584821f
https://pubmed.ncbi.nlm.nih.gov/24344356