Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Myles J, Lewis"'
Autor:
Cankut Çubuk, Rachel Lau, Pedro Cutillas, Vinothini Rajeeve, Christopher R. John, Anna E. A. Surace, Rebecca Hands, Liliane Fossati-Jimack, Myles J. Lewis, Costantino Pitzalis
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Kinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA). Oral inhibitors of Janus Kinase family (JAKs) are widely used in RA, while inhibitors of other kinase fami
Externí odkaz:
https://doaj.org/article/e05818fb70ad4c61af8d63ded8c3f639
Autor:
M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114614- (2024)
Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain
Externí odkaz:
https://doaj.org/article/cd2c68f5fde8412d87e766b66f097032
Autor:
Alessandra Nerviani, Marie-Astrid Boutet, Giulia Maria Ghirardi, Katriona Goldmann, Elisabetta Sciacca, Felice Rivellese, Elena Pontarini, Edoardo Prediletto, Federico Abatecola, Mattia Caliste, Sara Pagani, Daniele Mauro, Mattia Bellan, Cankut Cubuk, Rachel Lau, Sarah E. Church, Briana M. Hudson, Frances Humby, Michele Bombardieri, Myles J. Lewis, Costantino Pitzalis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The TAM tyrosine kinases, Axl and MerTK, play an important role in rheumatoid arthritis (RA). Here, using a unique synovial tissue bioresource of patients with RA matched for disease stage and treatment exposure, we assessed how Axl and MerT
Externí odkaz:
https://doaj.org/article/479b8ed47d1c4eb09e9de80de7cc33ef
Autor:
Ilaria Esposito, Ioanna Kontra, Chiara Giacomassi, Sotiria Manou-Stathopoulou, James Brown, Richard Stratton, Galateia Verykokou, Roberto Buccafusca, Michael Stevens, Ahuva Nissim, Myles J. Lewis, Paul E. Pfeffer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe chronic airway inflammation in severe eosinophilic asthma (SEA) suggests potential autoimmune aetiology with unidentified autoantibodies analogous to myeloperoxidase (MPO) in ANCA-positive EGPA (eosinophilic granulomatosis with polyangi
Externí odkaz:
https://doaj.org/article/d01ebbf6c94e4c32ae43a5c1b6aacc55
Autor:
Elisabetta Sciacca, Anna E. A. Surace, Salvatore Alaimo, Alfredo Pulvirenti, Felice Rivellese, Katriona Goldmann, Alfredo Ferro, Vito Latora, Costantino Pitzalis, Myles J. Lewis
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-14 (2022)
Abstract Background To determine whether gene-gene interaction network analysis of RNA sequencing (RNA-Seq) of synovial biopsies in early rheumatoid arthritis (RA) can inform our understanding of RA pathogenesis and yield improved treatment response
Externí odkaz:
https://doaj.org/article/e0a65c61fe5740cdb09f8f6ab51d5801
Publikováno v:
BMC Rheumatology, Vol 6, Iss 1, Pp 1-5 (2022)
Abstract Background Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with an overall poor prognosis. In October 2020, first line treatment with the PD-1 antagonist nivolumab and the CTLA-4 antagonist ipilimumab for unresectable di
Externí odkaz:
https://doaj.org/article/39ebde09f92c48369e8299729636f1cb
Autor:
Mohey Eldin M. El Shikh, Riham El Sayed, Nesreen Amer Ramadan Aly, Edoardo Prediletto, Rebecca Hands, Liliane Fossati-Jimack, Michele Bombardieri, Myles J. Lewis, Costantino Pitzalis
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Follicular dendritic cells (FDCs) fundamentally contribute to the formation of synovial ectopic lymphoid-like structures in rheumatoid arthritis (RA) which is associated with poor clinical prognosis. Despite this critical role, regulation of FDC deve
Externí odkaz:
https://doaj.org/article/364535c6c49b473285561a2da55f596e
Autor:
Manuela Schmidt, Julia Regina Sondermann, David Gomez-Varela, Cankut Çubuk, Queensta Millet, Myles J. Lewis, John N. Wood, Jing Zhao
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/808d70ea27fc4d60b7d71feeec7e9885
Autor:
Frances Humby, Patrick Durez, Maya H Buch, Myles J Lewis, Michele Bombardieri, Christopher John, Hasan Rizvi, Louise Warren, Joanna Peel, Liliane Fossati-Jimack, Rebecca E Hands, Giovanni Giorli, Felice Rivellese, Juan D Cañete, Peter C Taylor, Peter Sasieni, João E Fonseca, Ernest Choy, Costantino Pitzalis
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 9, Iss 7 (2022)
Background: Although biological therapies have transformed the outlook for those with rheumatoid arthritis, there is a lack of any meaningful response in approximately 40% of patients. The role of B cells in rheumatoid arthritis pathogenesis is well
Externí odkaz:
https://doaj.org/article/6d23cfaed3dc43e9b05659f3dd0b4105
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Since the first report of SARS-CoV-2 in China in 2019, there has been a huge debate about the origin. In this work, using a different method we aimed to strengthen the observation that no evidence of genetic manipulation has been found by (1
Externí odkaz:
https://doaj.org/article/8f5ad5791f7140adafe410f90355b306