Zobrazeno 1 - 10
of 1 940
pro vyhledávání: '"Myles J"'
Autor:
Cankut Çubuk, Rachel Lau, Pedro Cutillas, Vinothini Rajeeve, Christopher R. John, Anna E. A. Surace, Rebecca Hands, Liliane Fossati-Jimack, Myles J. Lewis, Costantino Pitzalis
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Kinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA). Oral inhibitors of Janus Kinase family (JAKs) are widely used in RA, while inhibitors of other kinase fami
Externí odkaz:
https://doaj.org/article/e05818fb70ad4c61af8d63ded8c3f639
Autor:
Alessandra Nerviani, Marie-Astrid Boutet, Giulia Maria Ghirardi, Katriona Goldmann, Elisabetta Sciacca, Felice Rivellese, Elena Pontarini, Edoardo Prediletto, Federico Abatecola, Mattia Caliste, Sara Pagani, Daniele Mauro, Mattia Bellan, Cankut Cubuk, Rachel Lau, Sarah E. Church, Briana M. Hudson, Frances Humby, Michele Bombardieri, Myles J. Lewis, Costantino Pitzalis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The TAM tyrosine kinases, Axl and MerTK, play an important role in rheumatoid arthritis (RA). Here, using a unique synovial tissue bioresource of patients with RA matched for disease stage and treatment exposure, we assessed how Axl and MerT
Externí odkaz:
https://doaj.org/article/479b8ed47d1c4eb09e9de80de7cc33ef
Autor:
M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114614- (2024)
Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain
Externí odkaz:
https://doaj.org/article/cd2c68f5fde8412d87e766b66f097032
Autor:
Ilaria Esposito, Ioanna Kontra, Chiara Giacomassi, Sotiria Manou-Stathopoulou, James Brown, Richard Stratton, Galateia Verykokou, Roberto Buccafusca, Michael Stevens, Ahuva Nissim, Myles J. Lewis, Paul E. Pfeffer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe chronic airway inflammation in severe eosinophilic asthma (SEA) suggests potential autoimmune aetiology with unidentified autoantibodies analogous to myeloperoxidase (MPO) in ANCA-positive EGPA (eosinophilic granulomatosis with polyangi
Externí odkaz:
https://doaj.org/article/d01ebbf6c94e4c32ae43a5c1b6aacc55
Autor:
Kyle Lam, Michael D. Abràmoff, José M. Balibrea, Steven M. Bishop, Richard R. Brady, Rachael A. Callcut, Manish Chand, Justin W. Collins, Markus K. Diener, Matthias Eisenmann, Kelly Fermont, Manoel Galvao Neto, Gregory D. Hager, Robert J. Hinchliffe, Alan Horgan, Pierre Jannin, Alexander Langerman, Kartik Logishetty, Amit Mahadik, Lena Maier-Hein, Esteban Martín Antona, Pietro Mascagni, Ryan K. Mathew, Beat P. Müller-Stich, Thomas Neumuth, Felix Nickel, Adrian Park, Gianluca Pellino, Frank Rudzicz, Sam Shah, Mark Slack, Myles J. Smith, Naeem Soomro, Stefanie Speidel, Danail Stoyanov, Henry S. Tilney, Martin Wagner, Ara Darzi, James M. Kinross, Sanjay Purkayastha
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-9 (2022)
Abstract The use of digital technology is increasing rapidly across surgical specialities, yet there is no consensus for the term ‘digital surgery’. This is critical as digital health technologies present technical, governance, and legal challeng
Externí odkaz:
https://doaj.org/article/13dd113b56794cc7a531bd4d4a9baa7e
Autor:
Elisabetta Sciacca, Anna E. A. Surace, Salvatore Alaimo, Alfredo Pulvirenti, Felice Rivellese, Katriona Goldmann, Alfredo Ferro, Vito Latora, Costantino Pitzalis, Myles J. Lewis
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-14 (2022)
Abstract Background To determine whether gene-gene interaction network analysis of RNA sequencing (RNA-Seq) of synovial biopsies in early rheumatoid arthritis (RA) can inform our understanding of RA pathogenesis and yield improved treatment response
Externí odkaz:
https://doaj.org/article/e0a65c61fe5740cdb09f8f6ab51d5801
Publikováno v:
International Journal of Agricultural Sustainability, Vol 20, Iss 3, Pp 346-367 (2022)
Digital agriculture is exciting attention because of an expectation that food systems will be disrupted by new digital technologies through improvements in precision, efficiency, volume, speed of process or identity of product. This is against the ba
Externí odkaz:
https://doaj.org/article/04151f60f73f44089278c8edc330fb82
Publikováno v:
BMC Rheumatology, Vol 6, Iss 1, Pp 1-5 (2022)
Abstract Background Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with an overall poor prognosis. In October 2020, first line treatment with the PD-1 antagonist nivolumab and the CTLA-4 antagonist ipilimumab for unresectable di
Externí odkaz:
https://doaj.org/article/39ebde09f92c48369e8299729636f1cb
Autor:
McCullough, J., Amon, A., Legnani, E., Gruen, D., Roodman, A., Friedrich, O., MacCrann, N., Becker, M. R., Myles, J., Dodelson, S., Samuroff, S., Blazek, J., Prat, J., Honscheid, K., Pieres, A., Ferté, A., Alarcon, A., Drlica-Wagner, A., Choi, A., Navarro-Alsina, A., Campos, A., Malagón, A. A. Plazas, Porredon, A., Farahi, A., Ross, A. J., Rosell, A. Carnero, Yin, B., Flaugher, B., Yanny, B., Sánchez, C., Chang, C., Davis, C., To, C., Doux, C., Brooks, D., James, D. J., Cid, D. Sanchez, Hollowood, D. L., Huterer, D., Rykoff, E. S., Gaztanaga, E., Huff, E. M., Suchyta, E., Sheldon, E., Sanchez, E., Tarsitano, F., Andrade-Oliveira, F., Castander, F. J., Bernstein, G. M., Gutierrez, G., Giannini, G., Tarle, G., Diehl, H. T., Huang, H., Harrison, I., Sevilla-Noarbe, I., Tutusaus, I., Ferrero, I., Elvin-Poole, J., Marshall, J. L., Muir, J., Weller, J., Zuntz, J., Carretero, J., DeRose, J., Frieman, J., Cordero, J., De Vicente, J., García-Bellido, J., Mena-Fernández, J., Eckert, K., Romer, A. K., Bechtol, K., Herner, K., Kuehn, K., Secco, L. F., da Costa, L. N., Paterno, M., Soares-Santos, 21 M., Gatti, M., Raveri, M., Yamamoto, M., Smith, M., Kind, M. Carrasco, Troxel, M. A., Aguena, M., Jarvis, M., Swanson, M. E. C., Weaverdyck, N., Lahav, O., Doel, P., Wiseman, P., Miquel, R., Gruendl, R. A., Cawthon, R., Allam, S., Hinton, S. R., Bridle, S. L., Bocquet, S., Desai, S., Pandey, S., Everett, S., Lee, S., Shin, T., Palmese, A., Conselice, C., Burke, D. L., Buckley-Geer, E., Lima, M., Vincenzi, M., Pereira, M. E. S., Crocce, M., Schubnell, M., Jeffrey, N., Alves, O., Vikram, V., Zhang, Y., Collaboration, DES
Modeling the intrinsic alignment (IA) of galaxies poses a challenge to weak lensing analyses. The Dark Energy Survey is expected to be less impacted by IA when limited to blue, star-forming galaxies. The cosmological parameter constraints from this b
Externí odkaz:
http://arxiv.org/abs/2410.22272
Autor:
Gallagher-Syed, Amaya, Pontarini, Elena, Lewis, Myles J., Barnes, Michael R., Slabaugh, Gregory
This study evaluates the generalisation capabilities of state-of-the-art histopathology foundation models on out-of-distribution multi-stain autoimmune Immunohistochemistry datasets. We compare 13 feature extractor models, including ImageNet-pretrain
Externí odkaz:
http://arxiv.org/abs/2410.21560