E-DNA IM or ID delivery prime enhances antibody and T cell responses following recombinant gp120 env boost

Autor: Hutnick NA, Karuppiah M, Pollara J, Yan J, Myles DJ, Broderick K, Morrow M, Sardasai N, Montefiori D, Barnett S, Ferrari G, Weiner DB

Publikováno v: Retrovirology, Vol 9, Iss Suppl 2, p P364 (2012)

Externí odkaz: https://doaj.org/article/1799da99e5984e669ba8555d64080dc0

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An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates.

Autor: Wise MC; Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA., Hutnick NA; Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA., Pollara J; Department of Surgery, Duke University, Durham, North Carolina, USA., Myles DJ; Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA., Williams C; Department of Pathology, New York University Medical Center, New York, New York, USA., Yan J; Inovio Pharmaceuticals, Plymouth Meeting, Pennsylvania, USA., LaBranche CC; Department of Surgery, Duke University, Durham, North Carolina, USA., Khan AS; Inovio Pharmaceuticals, Plymouth Meeting, Pennsylvania, USA., Sardesai NY; Inovio Pharmaceuticals, Plymouth Meeting, Pennsylvania, USA., Montefiori D; Department of Surgery, Duke University, Durham, North Carolina, USA., Barnett SW; Novartis Vaccines and Diagnostics, Inc., Cambridge, Massachusetts, USA., Zolla-Pazner S; Department of Pathology, New York University Medical Center, New York, New York, USA Veterans Affairs Medical Center, New York, New York, USA., Ferrari G; Department of Surgery, Duke University, Durham, North Carolina, USA., Weiner DB; Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA dbweiner@mail.med.upenn.edu.

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Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA.

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Intradermal DNA vaccination enhanced by low-current electroporation improves antigen expression and induces robust cellular and humoral immune responses.

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