Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Myles A. Brown"'
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Akademický článek
p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases
Autor: Jing Ni, Sheheryar Kabraji, Shaozhen Xie, Yanzhi Wang, Peichen Pan, Xiaofang He, Zongming Liu, Jose Palbo Leone, Henry W. Long, Myles A. Brown, Eric P. Winer, Deborah A. R. Dillon, Nancy U. Lin, Jean J. Zhao
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
HER2+ breast cancer often develop brain metastases (BCBMs) that are difficult to treat. Here, the authors show that p16INK4A loss in BCBMs from HER2+ breast tumors results in resistance to the HER2 inhibitor Tucatinib, and that CDK4/6 inhibition can
Externí odkaz: https://doaj.org/article/16bc242049ff4c6ca1e0501ace504822
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2
Abstract 4759: Dissecting EP300 and CBP function in prostate cancer models
Autor: Kiran Mirpuri, Alok K. Tewari, Myles A. Brown
Publikováno v: Cancer Research. 83:4759-4759
Prostate adenocarcincoma is dependent on androgen and its cellular receptor the androgen receptor (AR) for most of the natural history of the disease including progression to the advanced and lethal state. Many prostate cancer therapeutics target the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14511efed7acd29c52b5f7b26b418f14
https://doi.org/10.1158/1538-7445.am2023-4759
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4
p16
Autor: Jing, Ni, Sheheryar, Kabraji, Shaozhen, Xie, Yanzhi, Wang, Peichen, Pan, Xiaofang, He, Zongming, Liu, Jose Palbo, Leone, Henry W, Long, Myles A, Brown, Eric P, Winer, Deborah A R, Dillon, Nancy U, Lin, Jean J, Zhao
Publikováno v: Nature communications. 13(1)
Approximately 50% of patients with metastatic HER2-positive (HER2+) breast cancer develop brain metastases (BCBMs). We report that the tumor suppressor p16
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15b0ff92c3762d7498bc19e21519a704
https://pubmed.ncbi.nlm.nih.gov/35304445
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5
The paradox of risk assessment: comparing responses of fathead minnows to capture-released and diet-released alarm cues from two different predators
Autor: Douglas P. Chivers, Myles R. Brown, Maud C. O. Ferrari, Michael S. Pollock
Publikováno v: Chemoecology. 17:157-161
Many aquatic prey are known to use chemical alarm cues to assess their risk of predation. In fishes, such alarm cues can be released either through damage of the epidermis during a predatory attack (capture-released) or through release from the preda
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d96208f089d768253a8f78b66d28580
https://doi.org/10.1007/s00049-007-0373-0
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6
Prevention and Treatment of ER-Negative Breast Cancer
Autor: Myles A Brown
We have made very significant progress since the last report (two years) towards achieving the objectives of this Center as set out in the aims of the original proposal. In response to the need to develop targeted approaches for the prevention and tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71e09fc1f12e62f79081bfda6ac7a69d
https://doi.org/10.21236/ada443711
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8
Dynamics of Estrogen Receptor Transcription Complex Assembly in Breast Cancer
Autor: Eli Hesterman, Myles A. Brown, Yongfeng Shang
Estrogen plays a critical role in the development and progression of breast cancer. While endocrine therapies play an important part in breast cancer treatment, the failure of these therapies reflects a lack of knowledge concerning the molecular mech
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6af0a40b4a08b084262d4c5b759b2d2
https://doi.org/10.21236/ada412699
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