Targeted Metabolomics Analysis Suggests That Tacrolimus Alters Protection against Oxidative Stress

Autor: Marie Joncquel, Julie Labasque, Julie Demaret, Marie-Adélaïde Bout, Aghilès Hamroun, Benjamin Hennart, Mathieu Tronchon, Magali Defevre, Isabelle Kim, Alain Kerckhove, Laurence George, Mylène Gilleron, Anne-Frédérique Dessein, Farid Zerimech, Guillaume Grzych

Publikováno v: Antioxidants, Vol 12, Iss 7, p 1412 (2023)

Tacrolimus (FK506) is an immunosuppressant that is experiencing a continuous rise in usage worldwide. The related side effects are known to be globally dose-dependent. Despite numerous studies on FK506, the mechanisms underlying FK506 toxicity are st

Externí odkaz: https://doaj.org/article/984d6e22f4c44b10a8238bdd0ccb1327

Mutations in CYC1, Encoding Cytochrome c1 Subunit of Respiratory Chain Complex III, Cause Insulin-Responsive Hyperglycemia

Autor: Abdelhamid Slama, Anne Lombès, Sandra T. Cooper, Heni Abida, Chen-Hsien Su, Manuel Schiff, Alexander Tzagoloff, Kym Mina, Minal Menezes, Padma Sivadorai, Richard J.N. Allcock, Hélène Ogier de Baulny, Mylène Gilleron, John Christodoulou, Malgorzata Rak, David R. Thorburn, Nina Kresoje, Lisa G. Riley, Nigel G. Laing, Pierre Rustin, Mark R. Davis, Aurélien Bayot, Pauline Gaignard

Publikováno v: The American Journal of Human Genetics. 93(2):384-389

Many individuals with abnormalities of mitochondrial respiratory chain complex III remain genetically undefined. Here, we report mutations (c.288G>T [p.Trp96Cys] and c.643C>T [p.Leu215Phe]) in CYC1, encoding the cytochrome c1 subunit of complex III,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638b9978308e25ed63082b1db5c6dfaa

QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease

Autor: Emmanuelle Lacène, Mylène Gilleron, Manuel Schiff, Joao A. Paulo, Eric S. Goetzman, Virginia Guarani, Monique Elmaleh-Bergès, Hélène Ogier de Baulny, Anne Lombès, Clémence Labasse, J. Wade Harper, P. Rustin, Norma B. Romero, Apolline Imbard, Abdelhamid Slama, Pauline Gaignard, Dominique Chrétien, Agnès Bourillon, Paule Bénit, Jean-François Benoist, Imen Dorboz, Claude Jardel

Publikováno v: eLife, Vol 5 (2016)
eLife
eLife, 2016, ⟨10.7554/eLife.17163⟩
eLife, eLife Sciences Publication, 2016, ⟨10.7554/eLife.17163⟩
eLife, eLife Sciences Publication, 2016, 〈10.7554/eLife.17163〉

Previously, we identified QIL1 as a subunit of mitochondrial contact site (MICOS) complex and demonstrated a role for QIL1 in MICOS assembly, mitochondrial respiration, and cristae formation critical for mitochondrial architecture (Guarani et al., 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17396ad1a15d3186381f7250deb58b00
https://elifesciences.org/articles/17163

Severe respiratory complex III defect prevents liver adaptation to prolonged fasting

Autor: Pierre Lesimple, Neji Tebib, Tim M. Strom, Thomas Meitinger, Holger Prokisch, Guy Touati, Anne Lombès, Claude Jardel, Mylène Gilleron, Tobias B. Haack, Caroline L’hermitte-Stead, Hélène Ogier de Baulny, Sandrine Filaut, Laura S. Kremer, Hatem Azzouz

Publikováno v: Journal of Hepatology
Journal of Hepatology, 2016, 65 (2), pp.377-85. ⟨10.1016/j.jhep.2016.04.017⟩
Journal of Hepatology, Elsevier, 2016, 65 (2), pp.377-85. ⟨10.1016/j.jhep.2016.04.017⟩
Journal of Hepatology, Elsevier, 2016, 65 (2), pp.377-85. 〈10.1016/j.jhep.2016.04.017〉

Next generation sequencing approaches have tremendously improved the diagnosis of rare genetic diseases. It may however be faced with difficult clinical interpretation of variants. Inherited enzymatic diseases provide an invaluable possibility to eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac57137d8e07670b2d7e389689d19ed
https://www.hal.inserm.fr/inserm-01321215

NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis

Autor: Mylène Gilleron, Remi Neviere, Steve Lancel, Jessica Franczak, David Montaigne, Xavier Marechal

Publikováno v: Biochemical and biophysical research communications. 388(4)

Cumulative doses of doxorubicin, a potent anticancer drug, lead to serious myocardial dysfunction. Numerous mechanisms including apoptosis have been proposed to account for its cardiotoxicity. Cardiac apoptosis induced by doxorubicin has been related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e14dd63cdd60d1525ac230558cc16f
https://pubmed.ncbi.nlm.nih.gov/19699179