Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates.

Autor: Sébastien Goutal, Nicolas Tournier, Martine Guillermier, Nadja Van Camp, Olivier Barret, Mylène Gaudin, Michel Bottlaender, Philippe Hantraye, Sonia Lavisse

Publikováno v: PLoS ONE, Vol 15, Iss 10, p e0240228 (2020)

IntroductionKnowledge of the repeatability of quantitative parameters derived from [18F]FDG PET images is essential to define the group size and allow correct interpretation. Here we tested repeatability and accuracy of different [18F]FDG absolute an

Externí odkaz: https://doaj.org/article/51bb3114c4074d75b8a6f16febedf038

The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain

Autor: Guillaume Becker, Olivier Barret, Christian Lemaire, Alain Plenevaux, Martine Guillermier, André Luxen, Eric Salmon, Nadja Van Camp, Philippe Hantraye, Mylène Gaudin, Yann Bramoullé, Sébastien Goutal

Publikováno v: EJNMMI Research, Vol 11, Iss 1, Pp 1-9 (2021)

Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent and human,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cafb9c45fa238e8aa02a244b11b3a69
https://doaj.org/article/6d181ae0a04a4f74826c698f97fe1723

Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

Autor: Fanny Petit, Erwan Selingue, Charlène Joséphine, Gilles Bonvento, Gwenaëlle Auregan, Anne-Sophie Hérard, Marie D’orange, Emmanuel Brouillet, Carole Escartin, Martine Guillermier, Mylène Gaudin-Guérif, Alexis-Pierre Bemelmans, Pauline Gipchtein, Emma Augustin, Anastasie Maté de Gérando, Karine Cambon, Marie-Claude Gaillard, Philippe Hantraye, Lev Stimmer, Caroline Jan, David Blum, Kevin Carvalho

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, ⟨10.1093/brain/awab011⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, 12 (4), pp.1167-1182. ⟨10.3389/fneur.2021.654850⟩
Brain-A Journal of Neurology, 2021, 12 (4), pp.1167-1182. ⟨10.1093/brain/awab011⟩

Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-pathological features of tauopathies. Although tau protein is highly enriched in neurons and poorly expressed by astrocytes, the origin of astrocytic tau is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a567fe58b57d7ba47f62a4764c0b5c3
https://hal.archives-ouvertes.fr/hal-03203343

The pharmacokinetics of [

Autor: Sébastien, Goutal, Martine, Guillermier, Guillaume, Becker, Mylène, Gaudin, Yann, Bramoullé, André, Luxen, Christian, Lemaire, Alain, Plenevaux, Eric, Salmon, Philippe, Hantraye, Olivier, Barret, Nadja, Van Camp

Publikováno v: EJNMMI Research

Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent and human,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2f46ac2effe09981f10871d41cb7356
https://pubmed.ncbi.nlm.nih.gov/33826008

A42 Reactive astrocytes promote proteostasis in huntington’s disease

Autor: María Angeles Carrillo-de Sauvage, Lucile Ben Haim, Gilles Bonvento, Laurene Abjean, Mylène Gaudin, Alexis Bemelmans, Fanny Petit, Jean-François Deleuze, Robert Olaso, Anne-Sophie Hérard, Sueva Bernier, Céline Derbois, Martine Guillermier, Carole Escartin, Noelle Dufour, Philippe Hantraye, Emmanuel Brouillet, Pauline Gipstein

Publikováno v: Pathogenic mechanisms.

Astrocytes are essential partners for neurons and their role in Huntington’s disease (HD) is emerging. In HD, astrocytes change and become reactive. Astrocyte reactivity is characterized by morphological changes but its functional impact is still u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9dd52a00f54729813cb20a7525ffa33
https://doi.org/10.1136/jnnp-2018-ehdn.40