Supplementary Table 1, Figures 1 - 8 from PLA2R1 Mediates Tumor Suppression by Activating JAK2

Autor: David Bernard, Gérard Lambeau, Hélène Simonnet, Michael Gelb, Michael Perrais, Sébastien Aubert, Alain Puisieux, Xavier Leroy, Yvan de Launoit, Stéphanie Verbeke, Mylène Ferrand, Baptiste Gras, Benjamin Le Calvé, Clotilde Wiel, Helene Lallet-Daher, Delphine Gitenay, Christophe A. Girard, Arnaud Augert, David Vindrieux

PDF file - 326K, Supplementary Figure 1: The knockdown of PLA2R1 favors OIS escape. Supplementary Figure 2: The knockdown of PLA2R1 favors transformation. Supplementary Figure 3: The knockdown of PLA2R1 favors OIS escape in human normal keratinocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1d6f7ea4a0232b422887e273f56468
https://doi.org/10.1158/0008-5472.22396190

The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action

Autor: Robert Dante, Arnaud Augert, Naveenan Navaratnam, P Faull, Audrey Griveau, David Bernard, Mylène Ferrand, L Eberst, Guillaume Devailly, B Le Calvé, Jean-Marc Vanacker, David Vindrieux

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2016, 35 (38), pp.5033-5042. ⟨10.1038/onc.2016.43⟩
Europe PubMed Central

Little is known about the biological role of the phospholipase A2 receptor (PLA2R1) transmembrane protein. In recent years, PLA2R1 has been shown to have an important role in regulating tumor-suppressive responses via JAK2 activation, but the underly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef09621d87f27d80d5e5bd7771448fc6
https://hal.inrae.fr/hal-02956417

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

Autor: Gérard Lambeau, Léa Payen, David Bernard, David Vindrieux, Michael Perrais, Hélène Simonnet, Sébastien Aubert, Robert Dante, Arnaud Augert, Mylène Ferrand, Pascal Pigny, Guillaume Devailly, Benjamin Le Calvé

Publikováno v: Oncotarget
Oncotarget, 2014, 5 (4), pp.1004-1013. ⟨10.18632/oncotarget.1681⟩
Vindrieux, D, Devailly, G, Augert, A, Le Calvé, B, Ferrand, M, Pigny, P, Payen, L, Lambeau, G, Perrais, M, Aubert, S, Simonnet, H, Dante, R & Bernard, D 2014, ' Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth ', Oncotarget, vol. 5, no. 4, pp. 1004-13 . https://doi.org/10.18632/oncotarget.1681
Oncotarget 4 (5), 1004-1013. (2014)
Oncotarget, Impact journals, 2014, 5 (4), pp.1004-1013. ⟨10.18632/oncotarget.1681⟩

// David Vindrieux 1,2,3,4 , Guillaume Devailly 1,2,3,4 , Arnaud Augert 1,2,3,4 , Benjamin Le Calve 1,2,3,4 , Mylene Ferrand 1,2,3,4 , Pascal Pigny 5,6 , Lea Payen 1,2,3,4 , Gerard Lambeau 7 , Michael Perrais 5 , Sebastien Aubert 5,8 , Helene Simonne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863fe657e8856cea13cd4a6aca6be9d6
https://doi.org/10.18632/oncotarget.1681

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

Autor: David Bernard, Delphine Gitenay, Clotilde Wiel, Benjamin Le Calvé, Hélène Lallet-Daher, David Vindrieux, Mylène Ferrand, Natalia Prevarskaya, Hélène Simonnet, Arnaud Augert, Baptiste Gras

Publikováno v: Nature Communications
Nature Communications, 2014, 5 (1), ⟨10.1038/ncomms4792⟩
Wiel, C, Lallet-Daher, H, Gitenay, D, Gras, B, Le Calvé, B, Augert, A, Ferrand, M, Prevarskaya, N, Simonnet, H, Vindrieux, D & Bernard, D 2014, ' Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence ', Nature Communications, vol. 5, 3792 . https://doi.org/10.1038/ncomms4792
Nature Communications, Nature Publishing Group, 2014, 5 (1), ⟨10.1038/ncomms4792⟩

International audience; Senescence is involved in various pathophysiological conditions. Besides loss of retinoblastoma and p53 pathways, little is known about other pathways involved in senescence. Here we identify two calcium channels; inositol 1,4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced174cf995d9f03118148b6042e55fa
https://pubmed.ncbi.nlm.nih.gov/24797322

MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells

Autor: Pierre-Benoit Ancey, Hector Hernandez-Vargas, Tri Vuong, Mylène Ferrand, Maria Ouzounova, Zdenko Herceg, Chantal Matar, Carlo M. Croce, Florence Le Calvez Kelm, Geoffroy Durand

Publikováno v: BMC Genomics
BMC Genomics, BioMed Central, 2013, 14 (1), pp.139. ⟨10.1186/1471-2164-14-139⟩

Background A subset of breast cancer cells displays increased ability to self-renew and reproduce breast cancer heterogeneity. The characterization of these so-called putative breast tumor-initiating cells (BT-ICs) may open the road for novel therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fab15fa8c742f7b831e7fbcc2aaf6c5
https://hal.archives-ouvertes.fr/hal-02999169