Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mykola Roiuk"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Translation initiation is a highly regulated step needed for protein synthesis. Most cell-based mechanistic work on translation initiation has been done using non-stressed cells growing in medium with sufficient nutrients and oxygen. This ha
Externí odkaz:
https://doaj.org/article/aa995e485fde4214897cef7dbe41d269
Loss of Elp1 in cerebellar granule cell progenitors models ataxia phenotype of Familial Dysautonomia
Autor:
Frederik Arnskötter, Patricia Benites Goncalves da Silva, Mackenna E. Schouw, Chiara Lukasch, Luca Bianchini, Laura Sieber, Jesus Garcia-Lopez, Shiekh Tanveer Ahmad, Yiran Li, Hong Lin, Piyush Joshi, Lisa Spänig, Magdalena Radoš, Mykola Roiuk, Mari Sepp, Marc Zuckermann, Paul A. Northcott, Annarita Patrizi, Lena M. Kutscher
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106600- (2024)
Familial Dysautonomia (FD) is an autosomal recessive disorder caused by a splice site mutation in the gene ELP1, which disproportionally affects neurons. While classically characterized by deficits in sensory and autonomic neurons, neuronal defects i
Externí odkaz:
https://doaj.org/article/27595f3c5f8c4217868b4b0677549c70
Publikováno v:
Nucleic Acids Research. 51:3391-3409
Roughly half of animal mRNAs contain upstream open reading frames (uORFs). These uORFs can represent an impediment to translation of the main ORF since ribosomes usually bind the mRNA cap at the 5′ end and then scan for ORFs in a 5′-to-3′ fashi
Roughly half of animal mRNAs contain upstream Open Reading Frames (uORFs). These uORFs represent an impediment to translation of the main ORF since ribosomes usually bind the mRNA cap at the 5’ end and then scan for ORFs in a 5’-to-3’ fashion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9931034d2daaa4efc587f31e5d49779
https://doi.org/10.1101/2022.11.11.516176
https://doi.org/10.1101/2022.11.11.516176
Publikováno v:
Nucleic Acids Research
Phosphorylation of Ribosomal Protein S6 (RPS6) was the first post-translational modification of the ribosome to be identified and is a commonly-used readout for mTORC1 activity. Although the cellular and organismal functions of RPS6 phosphorylation a
Autor:
Gianluca Figlia, Sandra Müller, Anna M. Hagenston, Susanne Kleber, Mykola Roiuk, Jan-Philipp Quast, Nora ten Bosch, Damian Carvajal Ibañez, Daniela Mauceri, Ana Martin-Villalba, Aurelio A. Teleman
Publikováno v:
Nature cell biology. 24(9)
Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to appropriately regulate cellular anabolism and catabolism. During nutrient restriction, different organs in an animal do not respond equally, with vital organs being re
Autor:
Christian Göschl, Claudia Setzer, Katharina Jandrasits, Radka Slovak, Jonas Bertels, Wolfgang Busch, Gerrit T.S. Beemster, Mykola Roiuk
Publikováno v:
The New Phytologist
New phytologist
New phytologist
Summary From the cellular perspective, organ growth is determined by production and growth of cells. Uncovering how these two processes are coordinated is essential for understanding organogenesis and regulation of organ growth.We utilized phenotypic
Autor:
Thomas R Burkard, Mykola Roiuk, Hans-Christian Theussl, Angela M. Peer, Juergen A. Knoblich, Isabella Moll, Nina S. Corsini, Paul Moeseneder
Publikováno v:
Cell Stem Cell
Summary Stem cell-specific transcriptional networks are well known to control pluripotency, but constitutive cellular processes such as mRNA splicing and protein synthesis can add complex layers of regulation with poorly understood effects on cell-fa