BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy

Autor: Sandra Donkervoort, Niklas Krause, Mykola Dergai, Pomi Yun, Judith Koliwer, Svetlana Gorokhova, Janelle Geist Hauserman, Beryl B Cummings, Ying Hu, Rosemarie Smith, Prech Uapinyoying, Vijay S Ganesh, Partha S Ghosh, Kristin G Monaghan, Seby L Edassery, Pia E Ferle, Sarah Silverstein, Katherine R Chao, Molly Snyder, Sara Ellingwood, Diana Bharucha‐Goebel, Susan T Iannaccone, Matteo Dal Peraro, A Reghan Foley, Jeffrey N Savas, Véronique Bolduc, Dirk Fasshauer, Carsten G Bönnemann, Michael Schwake

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-17 (2021)

Abstract BET1 is required, together with its SNARE complex partners GOSR2, SEC22b, and Syntaxin‐5 for fusion of endoplasmic reticulum‐derived vesicles with the ER‐Golgi intermediate compartment (ERGIC) and the cis‐Golgi. Here, we report three

Externí odkaz: https://doaj.org/article/36e02f0c64b8417881fabf19320857cf

Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.

Autor: Olga Novokhatska, Mykola Dergai, Liudmyla Tsyba, Inessa Skrypkina, Valeriy Filonenko, Jacques Moreau, Alla Rynditch

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e70546 (2013)

BACKGROUND: Scaffolding proteins of the intersectin (ITSN) family, ITSN1 and ITSN2, are crucial for the initiation stage of clathrin-mediated endocytosis. These proteins are closely related but have implications in distinct pathologies. To determine

Externí odkaz: https://doaj.org/article/3c0fd27a465246b8bb5d5b8defdac249

A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6

Autor: Gabriela Caraveo, Kim A. Caldwell, Jessica Lacoste, Yongbo Zhang, Damian B. van Rossum, Marco Tonelli, Sergei Kuchin, Aishwarya Shevade, Sofia Zaichick, Anthony L. Gaeta, Guy A. Caldwell, Daayun Chung, Mikko Taipale, Jeffrey N. Savas, Shivani Agarwal, Dirk Fasshauer, G. Wiersum, Kaitlyn McGrath, Ludmilla Shuvalova, Wenyu Wen, Mykola Dergai, Andrew K. Shum

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 12, pp. e2016730118

Significance Ykt6 is a conserved SNARE that plays critical roles along multiple vesicular pathways. To achieve its function, Ykt6 cycles between the cytosol and membrane-bound compartments through reversible lipidation. The mechanism that regulates t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bd0e23041df6f7c5e6861afa9cb4ac
http://europepmc.org/articles/PMC8000380

Ubiquitin-ligase AIP4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN1

Autor: Mykola Dergai, Oleksandr Dergai, Alla Rynditch

Publikováno v: FEBS letters. 592(13)

At present, the role of ubiquitination of cargoes internalized from the plasma membrane is better understood than the consequences of ubiquitination of proteins comprising the endocytic machinery. Here, we show that the E3 ubiquitin ligase AIP4/ITCH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ad17a6579b87ba7074a1bddb81e4d5
https://pubmed.ncbi.nlm.nih.gov/29851086

Differential recognition of ITSN2/Ese2 by the SH2 domains of Fyn, Abl1, PLCg1 and PI3KR1 in mouse tissues

Autor: Alla Rynditch, L. O. Tsyba, Olga Novokhatska, Mykola Dergai, S. V. Pankivskyy

Publikováno v: Biopolymers and Cell, Vol 29, Iss 5, Pp 424-427 (2013)

Phosphorylation of endocytic adaptor ITSN2 that enabled its interaction with the SH2 domains of signaling proteins was recently reported. The aim of this study was to determine whether tissue-specific ITSN2 phosphorylation and subsequent recognition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6376a618d9a14d14974a8a11d955d752
https://doi.org/10.7124/bc.000834