Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mykhaylo V. Ruchko"'
Autor:
Masahiro Hashizume, Marc Mouner, Joshua M. Chouteau, Olena M. Gorodnya, Mykhaylo V. Ruchko, Glenn L. Wilson, Mark N. Gillespie, James C. Parker
Publikováno v:
Pharmaceuticals, Vol 7, Iss 8, Pp 894-912 (2014)
The mitochondrial targeted DNA repair enzyme, 8-oxoguanine DNA glycosylase 1, was previously reported to protect against mitochondrial DNA (mtDNA) damage and ventilator induced lung injury (VILI). In the present study we determined whether mitochondr
Externí odkaz:
https://doaj.org/article/aedabb7b3ee04d84a1a128d171da1058
Publikováno v:
International Journal of COPD, Vol 2011, Iss default, Pp 209-219 (2011)
Viktor M Pastukh1, Li Zhang2, Mykhaylo V Ruchko1, Olena Gorodnya1, Gina C Bardwell1, Rubin M Tuder2, Mark N Gillespie11Department of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, AL, USA; 2Program
Externí odkaz:
https://doaj.org/article/40093cf3101f4320806ab4b3b6aff2f3
Autor:
Jon D. Simmons, Donald M. Moe, Mykhaylo V. Ruchko, V.M. Pastukh, George E. Black, Gina C. Capley, Mark B. Roth, David Muscat, Matthew J. Martin, Olena M. Gorodnya, Kyle K. Sokol, Mark N. Gillespie
Publikováno v:
Journal of Trauma and Acute Care Surgery. 83:683-689
BACKGROUND Despite improvements in the management of severely injured patients, development of multiple organ dysfunction syndrome (MODS) remains a morbid complication of traumatic shock. One of the key attributes of MODS is a profound bioenergetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9c83acd348f7373fa0bf39989b26f8
https://doi.org/10.1097/ta.0000000000001593
https://doi.org/10.1097/ta.0000000000001593
Publikováno v:
Free Radical Biology and Medicine. 96:78-88
Mitochondria of mammalian cells contain multiple copies of mitochondrial (mt) DNA. Although mtDNA copy number can fluctuate dramatically depending on physiological and pathophysiologic conditions, the mechanisms regulating mitochondrial genome replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9c0991346cf1c53d4d1a46527c7f96
https://doi.org/10.1016/j.freeradbiomed.2016.04.011
https://doi.org/10.1016/j.freeradbiomed.2016.04.011
Autor:
Hiroyuki Otsuka, Kazi N. Islam, Jessica M. Bradley, David J. Lefer, Chelsea L. Organ, Olena M. Gorodnya, Mykhaylo V. Ruchko, Zhen Li, David J. Polhemus, Mark N. Gillespie, Shashi Bhushan, Glenn L. Wilson
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 314(2)
Oxidative stress results in mtDNA damage and contributes to myocardial cell death. mtDNA repair enzymes are crucial for mtDNA repair and cell survival. We investigated a novel, mitochondria-targeted fusion protein (Exscien1-III) containing endonuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14b6e6f826e51d7b1b76e7096441f8c
https://pubmed.ncbi.nlm.nih.gov/29146615
https://pubmed.ncbi.nlm.nih.gov/29146615
Autor:
Mykhaylo V. Ruchko, Mark N. Gillespie, Olena M. Gorodnya, Glenn L. Wilson, Boniface Obiako, Yann Leei Lee, Jon D. Simmons, Jamie L. Kuck, Viktor M. Pastukh
Publikováno v:
Shock (Augusta, Ga.). 48(1)
Although studies in rat cultured pulmonary artery endothelial cells, perfused lungs, and intact mice support the concept that oxidative mitochondrial (mt) DNA damage triggers acute lung injury (ALI), it has not yet been determined whether enhanced mt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc68edc83e33d1e69b2fe8a396e439b
https://pubmed.ncbi.nlm.nih.gov/28125528
https://pubmed.ncbi.nlm.nih.gov/28125528
Publikováno v:
Respiratory Physiology & Neurobiology. 174:244-251
Hypoxia, a fundamental stimulus in biology and medicine, uses reactive oxygen species (ROS) as second messengers. A surprising target of hypoxia-generated ROS is specific bases within hypoxic response elements (HREs) of the VEGF and other hypoxia-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce5e6f191877902e23048861858cdb
https://doi.org/10.1016/j.resp.2010.08.025
https://doi.org/10.1016/j.resp.2010.08.025
Publikováno v:
Annals of the New York Academy of Sciences. 1177:140-150
Hypoxia, a fundamental biological stimulus, uses reactive oxygen species (ROS) as second messengers. Surprising molecular targets of hypoxia-generated ROS are the specific bases within hypoxic response elements (HREs) of the vascular endothelial grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e488aee6db94b7db6816a6c75f75fd
https://doi.org/10.1111/j.1749-6632.2009.05036.x
https://doi.org/10.1111/j.1749-6632.2009.05036.x
Publikováno v:
Free Radical Biology and Medicine. 43:1616-1626
Reactive oxygen species associated with hypoxic signaling in pulmonary arterial endothelial cells (PAECs) oxidatively modify specific nucleotides in the hypoxic response element (HRE) of the VEGF gene (FASEB J.19:387-394; 2005). In this study, we det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a8c854878d364656894591babbea12
https://doi.org/10.1016/j.freeradbiomed.2007.08.027
https://doi.org/10.1016/j.freeradbiomed.2007.08.027
Autor:
Jared M McLendon, Diego F Alvarez, Olena M Gorodnya, Sergiy Sukhanov, Lyudmila I Rachek, Mark N Gillespie, Mykhaylo V Ruchko
Publikováno v:
Circulation. 132
Impaired mitochondrial proliferation and function may lead to heart failure. Mitochondrial biogenesis during postnatal cardiac development in rodents is accompanied by oxidative mitochondrial (mt) DNA damage and repair. How mtDNA damage is linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78141961c3ad76a01aba5a91bfbc26bf
https://doi.org/10.1161/circ.132.suppl_3.16301
https://doi.org/10.1161/circ.132.suppl_3.16301