Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Myers Richard H"'
Publikováno v:
BMC Neurology, Vol 10, Iss 1, p 23 (2010)
Abstract Background Women have a reduced risk of developing Parkinson's disease (PD) compared with age-matched men. Neuro-protective effects of estrogen potentially explain this difference. Tamoxifen, commonly used in breast cancer treatment, may int
Externí odkaz:
https://doaj.org/article/2e6dcf699123459cad08367232a24701
Autor:
Halter Cheryl, DeStefano Anita L, Mariani Claudio B, Pezzoli Gianni, Goldwurm Stefano, Wilk Jemma B, Dumitriu Alexandra, Pankratz Nathan, Latourelle Jeanne C, Gusella James F, Nichols William C, Myers Richard H, Foroud Tatiana
Publikováno v:
BMC Medical Genetics, Vol 10, Iss 1, p 98 (2009)
Abstract Background Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age may represent invalua
Externí odkaz:
https://doaj.org/article/9dc1cdf15dcf4c7f9d54fbb1026b0416
Autor:
Corbett Alastair, Nicholson Garth, Litvan Irene, Itin Ilia, Baker Kenneth B, DeStefano Anita L, Laramie Jason M, Huskey Karen W, Massood Tiffany, Wilk Jemma B, Nagle Michael W, Williamson Sally, Hendricks Audrey E, Saint-Hilaire Marie H, Zini Michela, Pezzoli Gianni, Goldwurm Stefano, Singer Carlos, Shill Holly A, Ahmed Anwar, Perlmutter Joel S, Guttman Mark, Racette Brad A, Watts Ray L, Wooten G Frederick, Growdon John H, Mark Margery H, Golbe Lawrence I, Klein Christine, Suchowersky Oksana, Lew Mark F, Sun Mei, Latourelle Jeanne C, Nance Martha, Drasby Edward, Isaacson Stuart, Burn David J, Chinnery Patrick F, Pramstaller Peter P, Al-hinti Jomana, Moller Anette T, Ostergaard Karen, Sherman Scott J, Roxburgh Richard, Snow Barry, Slevin John T, Cambi Franca, Gusella James F, Myers Richard H
Publikováno v:
BMC Medicine, Vol 6, Iss 1, p 32 (2008)
Abstract Background We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser (G2019S), is associated w
Externí odkaz:
https://doaj.org/article/f73c03813f604cc4a82de0bfb5bdb442
Autor:
Tobin Jennifer E, Latourelle Jeanne C, Nagle Michael W, Williamson Sally L, Wilk Jemma B, Laramie Jason M, Province Michael A, Borecki Ingrid B, Myers Richard H
Publikováno v:
BMC Medical Genetics, Vol 9, Iss 1, p 46 (2008)
Abstract Background The chromosome 7q32 region is linked to metabolic syndrome and obesity related traits in the Family Heart Study. As part of a fine mapping study of the region, we evaluated the relationship of polymorphisms to fasting glucose leve
Externí odkaz:
https://doaj.org/article/4e510c538acf4885a949795fbdf8cedd
Autor:
Corbett Jonathan, Arnett Donna, Hopkins Paul N, Myers Richard H, Tang Weihong, North Kari, Borecki Ingrid B, Kraja Aldi T, Adelman Avril, Province Michael A
Publikováno v:
Nutrition & Metabolism, Vol 3, Iss 1, p 41 (2006)
Abstract Background We report longitudinal changes in the metabolic syndrome (MetS) in 2,458 participants from 480 families in the Family Heart Study. Participants were examined between 1994–96 (FHS-T1) and 2002–03 (FHS-T2), about 7.4 years apart
Externí odkaz:
https://doaj.org/article/75a23f4cfb074d959e28613efac6f12a
Autor:
Myers Richard H, Djoussé Luc, Hakky Michael, Gillis Tammy, Zeng Wenqi, MacDonald Marcy E, Gusella James F
Publikováno v:
BMC Neuroscience, Vol 7, Iss 1, p 62 (2006)
Abstract Background In Huntington's disease (HD), age at neurological onset is inversely correlated with the length of the CAG trinucleotide repeat mutation, but can be modified by genetic factors beyond the HD gene. Association of a relatively infre
Externí odkaz:
https://doaj.org/article/f689c99d505b420b978cb9969e1e7ce5
Autor:
Gillis Tammy, Mysore Jayalakshmi, Djoussé Luc, Xu Gang, Prakash Ranjana, Wheeler Vanessa C, Lazzarini Alice, Ashizawa Tetsuo, Jones Randi, Paulsen Jane S, Frontali Marina, Novelletto Andrea, McCusker Elizabeth, Trent Ronald JA, Klimek Mary, Suchowersky Oksana, García Carmen, Gómez-Tortosa Estrella, Frati Luigi, Squitieri Ferdinando, Rosenblatt Adam, Margolis Russell L, Ross Christopher A, Nance Martha, Morrison Patrick J, Durr Alexandra, Warby Simon C, Hayden Michael R, Li Jian-Liang, Hakky Michael, Cupples L Adrienne, Saint-Hilaire Marie H, Cha Jang-Ho J, Hersch Steven M, Penney John B, Harrison Madaline B, Perlman Susan L, Zanko Andrea, Abramson Ruth K, Lechich Anthony J, Duckett Ayana, Marder Karen, Conneally P Michael, Gusella James F, MacDonald Marcy E, Myers Richard H
Publikováno v:
BMC Medical Genetics, Vol 7, Iss 1, p 71 (2006)
Abstract Background Age at onset of Huntington's disease (HD) is correlated with the size of the abnormal CAG repeat expansion in the HD gene; however, several studies have indicated that other genetic factors also contribute to the variability in HD
Externí odkaz:
https://doaj.org/article/e3f085610415408f8f263d3a98bea8fe
Autor:
Ellison R Curtis, Hunt Steven C, Wilk Jemma B, Laramie Jason M, Chakravarti Aravinda, Boerwinkle Eric, Myers Richard H
Publikováno v:
BMC Medical Genetics, Vol 7, Iss 1, p 17 (2006)
Abstract Background Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting g
Externí odkaz:
https://doaj.org/article/ca1dec530fde47a0aeaa3267c1eb1168
Autor:
Lewis Cora E, Heiss Gerardo, Myers Richard H, Pankow James S, Hunt Steven C, Kraja Aldi T, Rao DC, Province Michael A
Publikováno v:
Nutrition & Metabolism, Vol 2, Iss 1, p 2 (2005)
Abstract Background In 2001 the National Cholesterol Education Program (NCEP) provided a categorical definition for metabolic syndrome (c-MetS). We studied the extent to which two ethnic groups, Blacks and Whites were affected by c-MetS. The groups w
Externí odkaz:
https://doaj.org/article/4b8954c8e0094769abdeea0fc6f9af6e
Autor:
Ellis, Natalie, Tee, Amelia, McAllister, Branduff, Massey, Thomas, McLauchlan, Duncan, Stone, Timothy, Correia, Kevin, Loupe, Jacob, Kim, Kyung-Hee, Barker, Douglas, Hong, Eun Pyo, Chao, Michael J., Long, Jeffrey D., Lucente, Diane, Vonsattel, Jean Paul G., Pinto, Ricardo Mouro, Elneel, Kawther Abu, Ramos, Eliana Marisa, Mysore, Jayalakshmi Srinidhi, Gillis, Tammy, Wheeler, Vanessa C., Medway, Christopher, Hall, Lynsey, Kwak, Seung, Sampaio, Cristina, Ciosi, Marc, Maxwell, Alastair, Chatzi, Afroditi, Monckton, Darren G., Orth, Michael, Landwehrmeyer, G. Bernhard, Paulsen, Jane S., Shoulson, Ira, Myers, Richard H., van Duijn, Erik, Rickards, Hugh, MacDonald, Marcy E., Lee, Jong-min, Gusella, James F., Jones, Lesley, Holmans, Peter
Publikováno v:
In Biological Psychiatry 1 May 2020 87(9):857-865