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Publikováno v:
In Tetrahedron Letters 1999 40(51):8975-8978
Autor:
Moree, Wilna J., Kataoka, Ken-ichiro, Ramirez-Weinhouse, Michele M., Shiota, Tatsuki, Imai, Minoru, Tsutsumi, Takaharu, Sudo, Masaki, Endo, Noriaki, Muroga, Yumiko, Hada, Takahiko, Fanning, Dewey, Saunders, John, Kato, Yoshinori, Myers, Peter L., Tarby, Christine M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2008 18(6):1869-1873
Publikováno v:
Molecular Cancer Therapeutics. 10:B64-B64
In this presentation we will present the chemical structure, biological activity and pharmacokinetic (PK) properties of BMN 673, a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. PARP-1 and -2 are key nuclear enzymes that are activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c4073091bafd47163ed6a66242f8cf
https://doi.org/10.1158/1535-7163.targ-11-b64
https://doi.org/10.1158/1535-7163.targ-11-b64
Publikováno v:
Molecular Cancer Therapeutics. 8:A121-A121
Poly (ADP-ribose) polymerases (PARP) -1 and -2 are key enzymes that are activated by DNA damage and play a critical role in the base excision DNA repair (BER) pathway. Previous studies have indicated that inhibitors of PARP-1 and -2 could enhance the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa5769bef055e503122b26d8a309fec
https://doi.org/10.1158/1535-7163.targ-09-a121
https://doi.org/10.1158/1535-7163.targ-09-a121
Autor:
Moree, Wilna J. *, Kataoka, Ken-ichiro, Ramirez-Weinhouse, Michele M., Shiota, Tatsuki, Imai, Minoru, Sudo, Masaki, Tsutsumi, Takaharu, Endo, Noriaki, Muroga, Yumiko, Hada, Takahiko, Tanaka, Hiroko, Morita, Takuya, Greene, Jonathan, Barnum, Doug, Saunders, John, Kato, Yoshinori, Myers, Peter L., Tarby, Christine M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2004 14(21):5413-5416