Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Myers, Michael R."'
Autor:
MYERS, MICHAEL R.1
Publikováno v:
Indiana Journal of Global Legal Studies. 2018, Vol. 25 Issue 1, p495-511. 17p.
Autor:
Robert J. Leadley, Charles Kasiewski, Tara Wentz, Glenda E. Bilder, Jeffery Bostwick, Mark H. Perrone, Saul J. Needle, Betsey O’Conner, Christopher T. Dunwiddie, Lisa Byan, Kenneth Page, Helen Galczenski, Linda Merkel, Persons Paul E, Myers Michael R, Alfred P. Spada, Amin Dilip, Cuong Ly
Publikováno v:
Circulation. 99:3292-3299
Background —Platelet-derived growth factor (PDGF), a purported mediator of arterial response to injury, stimulates proliferation, chemotaxis, and matrix production by activation of its membrane receptor tyrosine kinase. Because these activities und
Autor:
Chin-Yi J. Hsu, Myers Michael R, Asher Zilberstein, Susan E. Johnson, Linda E. Hook, Mary V. Jacoski, Alfred P. Spada, Allison L. Zulli, Natalie N. Setzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:417-420
We report herein our preliminary results of a SAR study of quinazoline-based inhibitors of p56lck and EGF-R tyrosine kinase activity.1 The most potent inhibitor of p56lck identified, RPR-108518A (10), has an IC50 of 0.50 μM. The 3-chlorophenoxy- and
Autor:
Asher Zilberstein, Allison L. Zulli, Alfred P. Spada, Persons Paul E, Daniel L. Cheney, Myers Michael R, Karen J. Mitchell, Carol Franks, Susan E. Johnson, Natalie N. Setzer, Cuong Ly, Martin P. Maguire
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:421-424
We have identified moderately potent and selective inhibitors of CSF-1R tyrosine kinase activity.1 A preliminary SAR study resulted in the identification of compounds 11 and 20 as the most potent analogues in the series (IC50 = 0.18 μM). The 3-D-con
Autor:
Myers Michael R, Alfred P. Spada
Publikováno v:
Expert Opinion on Therapeutic Patents. 5:805-817
Inhibitors of tyrosine kinases may be effective in the treatment of certain cancers and chronic inflammatory conditions for which current therapy is either inadequate or lacking. As such, tyrosine kinase inhibitors are attractive targets for pharmace
Autor:
Carol Franks, Asher Zilberstein, Myers Michael R, Martin P. Maguire, Persons Paul E, Alfred P. Spada, Allison L. Zulli, K. J. Mitchell, Susan E. Johnson, Natalie N. Setzer, Cuong Ly, Daniel L. Cheney
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 29
Autor:
Matthew J. McVey, Lisa A. Morgan, Wei He, Glenda Bilder, Spada Alfred P, Chandra Natajaran, Mark H. Perrone, Yongyi Luo, Saul Needle, Amin Dilip, Myers Michael R, Robert J. Leadley, Helen Galczenski
Publikováno v:
Journal of cardiovascular pharmacology. 41(6)
Activities of vascular smooth muscle cells (SMCs) such as proliferation, migration, and matrix production contribute to restenosis following clinical interventions of angioplasty and stent placement. Because activation of platelet-derived growth fact
Autor:
Spada Alfred P, Wei He, Stephen M. Condon, Dennis Colussi, Myers Michael R, Christopher J. Burns, Karen Brown, Michael R. Becker, Barbara Hanney, Valeria Chu
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(6)
Benzimidazoles and their isosteric compounds as factor Xa inhibitors are discussed
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