Výsledky vyhledávání

Developmental hierarchy during early human B-cell ontogeny after autologous bone marrow transplantation using autografts depleted of CD19+ B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein

Autor: Fatih M. Uckun, Haissig S, Ja, Ledbetter, Fidler P, Myers DE, Kuebelbeck V, Weisdorf D, Gajl-Peczalska K, Jh, Kersey, Nk, Ramsay

Publikováno v: Europe PubMed Central

Sequential immunophenotypes of bone marrow (BM) and peripheral blood (PBL) lymphoid cells from 15 B-lineage acute lymphoblastic leukemia (ALL) patients who underwent autologous bone marrow transplantation (BMT) during complete remission were determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc70ada1f8a62dda76033804b1bac485
https://doi.org/10.1182/blood.v79.12.3369.3369

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In vivo biotherapy of HL-60 myeloid leukemia with a genetically engineered recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor

Autor: Jp, Perentesis, Gunther R, Waurzyniak B, Yanishevski Y, Myers DE, Ek O, Messinger Y, Shao Y, Lm, Chelstrom, Schneider E, We, Evans, Fatih M. Uckun

Publikováno v: Europe PubMed Central

Acute myeloid leukemia (AML) is the most common form of acute leukemia. Contemporary chemotherapy regimens fail to cure most patients with AML. We have genetically engineered a recombinant diphtheria toxin human granulocyte macrophage colony-stimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b6bd0cd53138ab0548720a8a12d5f86b
https://pubmed.ncbi.nlm.nih.gov/9815618

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Treatment of human B-cell precursor leukemia in SCID mice using a combination of the investigational biotherapeutic agent B43-PAP with cytosine arabinoside

Autor: Messinger Y, Yanishevski Y, Vi, Avramis, Ek O, Lm, Chelstrom, Gunther R, Myers DE, Jd, Irvin, Evans W, Fatih M. Uckun

Publikováno v: Europe PubMed Central

Combined immunochemotherapy regimens using the investigational biotherapeutic agent B43(anti-CD19)-poke-weed antiviral protein (PAP) immunotoxin may offer an effective treatment for refractory B-cell precursor leukemias. The purpose of the present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d9b517f5ee8188f523b90a328c5b00e9
https://pubmed.ncbi.nlm.nih.gov/9816330

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In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells

Autor: Kg, Waddick, Myers DE, Gunther R, Lm, Chelstrom, Chandan-Langlie M, Jd, Irvin, Tumer N, Fatih M. Uckun

Publikováno v: Europe PubMed Central

B-cell precursor (BCP) leukemia is the most common form of childhood cancer and represents one of the most radiation-resistant forms of human malignancy. In this study, we examined the antileukemic efficacy of the B43 (anti-CD19)-pokeweed antiviral p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d8fcf041eff965654984fae910b4bc6a
https://pubmed.ncbi.nlm.nih.gov/7492781

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Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin

Autor: Gunther R, Lm, Chelstrom, Tuel-Ahlgren L, Simon J, Myers DE, Fatih M. Uckun

Publikováno v: Europe PubMed Central

The study of central nervous system (CNS) leukemia has been hampered by the lack of a suitable animal model. We report that severe combined immunodeficiency (SCID) mice invariably develop rapidly progressive fatal CNS leukemia within 3 weeks after in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3124dfe52ea98d6c0664294c5c164066
https://pubmed.ncbi.nlm.nih.gov/7537120

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Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide

Autor: Fatih M. Uckun, Lm, Chelstrom, Finnegan D, Tuel-Ahlgren L, Manivel C, Jd, Irvin, Myers DE, Gunther R

Publikováno v: Europe PubMed Central

A highly aggressive human CALLA+C mu+ pre-B acute lymphoblastic leukemia (ALL) cell line (NALM-6-UM1) causes disseminated and invariably fatal leukemia in CB.17 mice with severe combined immunodeficiency (SCID). We used this SCID mouse model of human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f77e86ba73982b0bf188f93f51074dc
https://pubmed.ncbi.nlm.nih.gov/1375841

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Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging

Autor: Fatih M. Uckun, Jh, Kersey, Da, Vallera, Ja, Ledbetter, Weisdorf D, Myers DE, Haake R, Nk, Ramsay

Publikováno v: Europe PubMed Central

Fourteen patients with high-risk T-lineage acute lymphoblastic leukemia (ALL) in complete remission underwent autologous bone marrow transplantation (BMT) in an attempt to eradicate their residual disease burden. A combined immunochemotherapy protoco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98063ada8a87b154a324895b6b6b7d5c
https://pubmed.ncbi.nlm.nih.gov/2224122

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