Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Myeong Hwi Lee"'
Publikováno v:
Molecules, Vol 24, Iss 15, p 2808 (2019)
Autotaxin (ATX) is a potential drug target that is associated with inflammatory diseases and various cancers. In our previous studies, we have designed several inhibitors targeting ATX using computational and experimental approaches. Here, we have an
Externí odkaz:
https://doaj.org/article/a2a6fc6e612840dc8ff00229370cb6dd
Autor:
Myeong Hwi Lee, Anand Balupuri, Ye-rim Jung, Sungwook Choi, Areum Lee, Young Sik Cho, Nam Sook Kang
Publikováno v:
Molecules, Vol 23, Iss 12, p 3136 (2018)
Protein kinases are deeply involved in immune-related diseases and various cancers. They are a potential target for structure-based drug discovery, since the general structure and characteristics of kinase domains are relatively well-known. However,
Externí odkaz:
https://doaj.org/article/554bccca55ef4ef1af34875c56bcc9df
Autor:
Yong Ju Kim, Nam Sook Kang, Tae Kyo Park, Jinyeong Kim, Myeong Hwi Lee, Park Kyung Eun, Hyoungrae Kim, Ho Young Song
Publikováno v:
Bulletin of the Korean Chemical Society. 37:1105-1113
Factor XIa (FXIa) is an enzyme that is activated during the earliest stage of initiation of the intrinsic pathway of the blood coagulation mechanism. In this study, we attempted to discover a new FXIa inhibitor based on structure-based molecular mode
Autor:
Sung Sub Kim, Jong Woo Jeong, Ji-Hoon Oh, Yu Geun Ji, Yu Mi Shin, Tae-Sung Koo, Tae-Yoon Kim, Myeong Hwi Lee, Nam Sook Kang, Weontae Lee
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 164
The antioxidant enzyme human extracellular superoxide dismutase (SOD3) is a promising biopharmaceutical candidate for the treatment of various diseases. To support the early development of SOD3 as a biopharmaceutical, a simple, sensitive, and rapid l
Autor:
Eunmi Jung, Ji-Na You, Young-Jae Yang, Dae-Yon Lee, Tae-Sung Koo, Nam Sook Kang, Sangeun Chae, Kim Yun Ki, Dae-Hyuck Kang, Jong-Woo Jeong, So Jung Son, Myeong Hwi Lee, Jeonghee Ryu, Woosub Yoon, Anand Balupuri, Hyunjin Kwon
Publikováno v:
European journal of medicinal chemistry. 148
Autotaxin (ATX) is a potential target for the treatment of various cancers. A new series of ATX inhibitors was rationally designed and synthesized based on our previous study. Biological evaluation and structure-activity relationship (SAR) of this se
Autor:
Jeonghee Ryu, Myeong Hwi Lee, Kim Yun Ki, Eunmi Jung, Nam Sook Kang, Anand Balupuri, Sangeun Chae, Dae-Yon Lee
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(17)
The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathway is involved in several human diseases such as cancer, autoimmune diseases, inflammatory diseases neurodegenerative diseases and fibrotic diseases. Herein, a series of 4-phenyl-thiazole ba