Menthol Modulates Pacemaker Potentials through TRPA1 Channels in Cultured Interstitial Cells of Cajal from Murine Small Intestine

Autor: Hyun Jung Kim, Jinhong Wie, Insuk So, Myeong Ho Jung, Ki-Tae Ha, Byung Joo Kim

Publikováno v: Cellular Physiology and Biochemistry, Vol 38, Iss 5, Pp 1869-1882 (2016)

Background/Aims: ICCs are the pacemaker cells responsible for slow waves in gastrointestinal (GI) smooth muscle, and generate periodic pacemaker potentials in current-clamp mode. Methods: The effects of menthol on the pacemaker potentials of cultured

Externí odkaz: https://doaj.org/article/6e2d5caa99ca4ed69682b073e9b55464

Histone H3K9 Demethylase JMJD2B Activates Adipogenesis by Regulating H3K9 Methylation on PPARγ and C/EBPα during Adipogenesis.

Autor: Min-Kyung Jang, Ji-Hyun Kim, Myeong Ho Jung

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0168185 (2017)

Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) contribute to the repression

Externí odkaz: https://doaj.org/article/ee96c48f03964e0aa93b869c8134d8dc

Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2

Autor: Ji Hyun Kim, Dae Young Jung, Arukumar Nagappan, Nanjoo Suh, Myeong Ho Jung

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 20; Pages: 11085
International Journal of Molecular Sciences, Vol 22, Iss 11085, p 11085 (2021)

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. While the development of NAFLD is correlated with aberrant histone methylation, modifiers of histone methylation involved in this event remain poorly understood. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5096673a54ca282edffcf59dff142a0
https://pubmed.ncbi.nlm.nih.gov/34681759

Anti-Obesity Effects of Tanshinone I from Salvia miltiorrhiza Bunge in Mice Fed a High-Fat Diet through Inhibition of Early Adipogenesis

Autor: Dae Young Jung, Myeong Ho Jung, Ji Hyun Kim

Publikováno v: Nutrients, Vol 12, Iss 1242, p 1242 (2020)
Nutrients
Volume 12
Issue 5

Tanshinone I (Tan I) is a diterpenoid isolated from Salvia miltiorrhiza Bunge and exhibits antitumor effects in several cancers. However, the anti-obesity properties of Tan I remain unexplored. Here, we evaluated the anti-obesity effects of Tan I in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33330da7d4abf86b5014999d046eb990
https://www.mdpi.com/2072-6643/12/5/1242

Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase

Autor: Dae Young Jung, Myeong Ho Jung, Jihyun Kim, Ho-Young Lee

Publikováno v: Biochemical and Biophysical Research Communications. 494:587-593

Gomisin N (GN) is a lignan derived from Schisandra chinensis. AMP-activated kinase (AMPK) has gained attention as a therapeutic target for the treatment of metabolic syndrome. Previously, we reported that GN activated the AMPK pathway and ameliorated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11243856bcb0c33400af6505ce0a27a7
https://doi.org/10.1016/j.bbrc.2017.10.120