Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes

Autor: Rotroff, Daniel M, Yee, Sook Wah, Zhou, Kaixin, Marvel, Skylar W, Shah, Hetal S, Jack, John R, Havener, Tammy M, Hedderson, Monique M, Kubo, Michiaki, Herman, Mark A, Gao, He, Mychaleckyi, Josyf C, McLeod, Howard L, Doria, Alessandro, Giacomini, Kathleen M, Pearson, Ewan R, Wagner, Michael J, Buse, John B, Motsinger-Reif, Alison A, MetGen Investigators, ACCORD/ACCORDion Investigators

Publikováno v: Diabetes, vol 67, iss 7

Metformin is the first-line treatment for type 2 diabetes (T2D). Although widely prescribed, the glucose-lowering mechanism for metformin is incompletely understood. Here, we used a genome-wide association approach in a diverse group of individuals w

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Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.

Autor: Rotroff, Daniel M., Pijut, Sonja S., Marvel, Skylar W., Jack, John R., Havener, Tammy M., Pujol, Aurora, Schluter, Agatha, Graf, Gregory A., Ginsberg, Henry N., Shah, Hetal S., Gao, He, Morieri, Mario‐Luca, Doria, Alessandro, Mychaleckyi, Josyf C., McLeod, Howard L., Buse, John B., Wagner, Michael J., Motsinger‐Reif, Alison A., the ACCORD/ACCORDion Investigators

Publikováno v: Clinical Pharmacology & Therapeutics; Apr2018, Vol. 103 Issue 4, p712-721, 10p

Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.

Autor: Rotroff DM; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA.; Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA., Pijut SS; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA., Marvel SW; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA., Jack JR; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA., Havener TM; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA., Pujol A; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), and CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Schluter A; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), and CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain., Graf GA; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA.; Center for Pharmaceutical Research and Innovation, University of Kentucky, Lexington, Kentucky, USA.; Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA., Ginsberg HN; Irving Institute for Clinical and Translational Research, Columbia University College of Physicians and Surgeons, New York, New York, USA., Shah HS; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA., Gao H; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA., Morieri ML; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA., Doria A; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA., Mychaleckyi JC; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., McLeod HL; Moffitt Cancer Center, Tampa, Florida, USA., Buse JB; Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Wagner MJ; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA., Motsinger-Reif AA; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA.; Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2018 Apr; Vol. 103 (4), pp. 712-721. Date of Electronic Publication: 2017 Nov 03.