Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During AgingSummary

Autor: Huihuang Yan, Khashayarsha Khazaie, Gianrico Farrugia, Sabriya A. Syed, Michelle Wehling-Henricks, Makoto Kuro-o, Simon J. Gibbons, Sergiy M. Kvasha, David T. Asuzu, Rea A. Nagy, Eduardo N. Chini, Mahendra Pal Singh, Yujiro Hayashi, David R. Linden, James G. Tidball, Gabriella B. Gajdos, Michael R. Bardsley, Jair Machado Espindola Netto, Siva Arumugam Saravanaperumal, Todd A. Kellogg, Tamas Ordog, Yoshitaka Toyomasu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells of Cajal (ICC) decline with age in humans, and their loss contributes to g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1a15d90b0466d35d9517a3a039e81b
http://www.sciencedirect.com/science/article/pii/S2352345X2030117X

Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats

Autor: Oluwatobi T. Somade, Latifah A. Jimoh, Oyinkansola E. Olunaike, Babajide O. Ajayi

Publikováno v: Biochemistry and Biophysics Reports, Vol 24, Iss, Pp 100806-(2020)
Biochemistry and Biophysics Reports

2-methoxyethanol (2-ME) is an organic solvent widely used in the manufacture of brake fluids, paints, resins, varnish, nail polish, acetate cellulose, wood coloring, and as a plasticizer in plastics manufacturing. We therefore, investigated its effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9921c8fbccdaca16dde096c1793434
http://www.sciencedirect.com/science/article/pii/S2405580820301163

Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice

Autor: Alice P. Sowton, Andrew J. Murray, Simon James Tunster, Erica D. Watson, Ben D. McNally, Nisha Padmanabhan, Julian L. Griffin, Antonio Murgia, Aisha Yusuf

Publikováno v: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 23, Iss, Pp-(2020)

Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the mechanism through which this occurs is unclear. To improve our understanding of this link,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5de79e1f7ef67cef5ce425b58d812c6
http://hdl.handle.net/10044/1/82233

Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies

Autor: Neelam Sharma-Walia, Arun George Paul, Bala Chandran

Publikováno v: Translational Research

The role of cyclooxygenase-2 (COX-2), its lipid metabolite prostaglandin E2 (PGE2), and Eicosanoid (EP) receptors (EP; 1-4) underlying the proinflammatory mechanistic aspects of Burkitt's lymphoma, nasopharyngeal carcinoma, cervical cancer, prostate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321425b0d82dabef4271a72740ae0ba9
https://doi.org/10.1016/j.trsl.2013.03.004

MYC (v-myc myelocytomatosis viral oncogene homolog (avian))

Autor: NB Atkin

Publikováno v: Atlas of Genetics and Cytogenetics in Oncology and Haematology.

Review on MYC (v-myc myelocytomatosis viral oncogene homolog (avian)), with data on DNA, on the protein encoded, and where the gene is implicated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd358fb6b9e044893dd21387e641edb6
https://doi.org/10.4267/2042/37661