Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Myat Lin Oo"'
Autor:
Kareem Rashid Rumah, Yinghua Ma, Jennifer R Linden, Myat Lin Oo, Josef Anrather, Nicole Schaeren-Wiemers, Miguel A Alonso, Vincent A Fischetti, Mark S McClain, Timothy Vartanian
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004896 (2015)
Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been propo
Externí odkaz:
https://doaj.org/article/48225ba227d4434f91fe017f57c9a149
Autor:
Timothy Hla, Victoria A. Blaho, David K. Han, Shobha Thangada, Sung-Hee Chang, Ming-Tao Wu, Sun-Il Hwang, Myat Lin Oo, Karim Rezaul
Publikováno v:
Journal of Clinical Investigation. 121:2290-2300
GPCR inhibitors are highly prevalent in modern therapeutics. However, interference with complex GPCR regulatory mechanisms leads to both therapeutic efficacy and adverse effects. Recently, the sphingosine-1-phosphate (S1P) receptor inhibitor FTY720 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ad4b57a700efce4f53a2e31c3476db
https://doi.org/10.1172/jci45403
https://doi.org/10.1172/jci45403
Autor:
Kevin R. Lynch, Catherine H. Liu, Timothy Hla, Chen-Yong Lin, Ming-Tao Wu, Timothy L. Macdonald, Myat Lin Oo, Shobha Thangada
Publikováno v:
Journal of Biological Chemistry. 282:9082-9089
Sphingosine 1-phosphate (S1P), a multifunctional lipid mediator, regulates lymphocyte trafficking, vascular permeability, and angiogenesis by activation of the S1P1 receptor. This receptor is activated by FTY720-P, a phosphorylated derivative of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a242b3130b36a61e13c6f8239aed4b
https://doi.org/10.1074/jbc.m610318200
https://doi.org/10.1074/jbc.m610318200
Autor:
Yinghua Ma, Vincent A. Fischetti, Josef Anrather, Miguel A. Alonso, Myat Lin Oo, Jennifer R. Linden, Kareem Rashid Rumah, Nicole Schaeren-Wiemers, Timothy Vartanian, Mark S. McClain
Publikováno v:
PLoS Pathogens
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens, Vol 11, Iss 5, p e1004896 (2015)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens, Vol 11, Iss 5, p e1004896 (2015)
© 2015 Rumah et al. Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41483d703a6f684b116f17c58018c38a
http://europepmc.org/articles/PMC4439126
http://europepmc.org/articles/PMC4439126
Autor:
Krishnan Venkataraman, Faraz Idris Khan, Ming-Tao Wu, Myat Lin Oo, Youxi Ai, Jason Michaud, Nehal S. Parikh, Yong-Moon Lee, Richard L. Proia, Shobha Thangada, Timothy Hla
Publikováno v:
Biochemical Journal. 397:461-471
Sphingosine 1-phosphate (S1P), produced by Sphks (sphingosine kinases), is a multifunctional lipid mediator that regulates immune cell trafficking and vascular development. Mammals maintain a large concentration gradient of S1P between vascular and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b88860d54e22ffc3a396229625f6e9
https://doi.org/10.1042/bj20060251
https://doi.org/10.1042/bj20060251
Publikováno v:
Genes to Cells. 8:515-523
Background: Matrix metalloproteinases including MMP-9 mediate matrix destruction during chronic inflammatory diseases such as arthritis and atherosclerosis. MMP-9 up-regulation by inflammatory cytokines involve interactions between several transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541b97e56bcfc026d12a2db1bcb29fed
https://doi.org/10.1046/j.1365-2443.2003.00652.x
https://doi.org/10.1046/j.1365-2443.2003.00652.x
Autor:
Takeshi Senga, Naing Naing Mon, Myat Lin Oo, Pengyu Huang, Aye Aye Thant, Arm Ruhul Amin, Michinari Hamaguchi
Publikováno v:
Oncogene. 22:1411-1417
To evaluate the function of cysteine residues of the Src kinase, we constructed a series of Src mutants in which some of cysteines were replaced to alanines. With these mutants, we studied the effect of SH-alkylating agents, N-[p-(2-benzimidazolyl)ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8169f7786995caa096b9c0971bd227
https://doi.org/10.1038/sj.onc.1206286
https://doi.org/10.1038/sj.onc.1206286
Autor:
Kumi Oshima, Satoru Matsuda, Kazuya Machida, Ali Reja Mohammad Ruhul Amin, Aye Aye Thant, Tomohiro Kurosaki, Anwarul A. Akhand, Michinari Hamaguchi, Takeshi Senga, Myat Lin Oo, Akito Maeda
Publikováno v:
Oncogene. 21:8871-8878
We investigated the role of SHPS-1/SIRPα1 in IL-1β- and TNFα-dependent signaling that leads to the activation of Erk 1/2 and Akt. Treatment of Balb3T3 cells with IL-1β or TNFα activated tyrosine phosphorylation of SHPS-1, its association with SH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a2e7dc1a015d949c41cb20ebe262681
https://doi.org/10.1038/sj.onc.1206018
https://doi.org/10.1038/sj.onc.1206018
Autor:
Myat Lin Oo, Timothy Hla
Publikováno v:
Journal of Clinical Investigation. 120:90-92
Inflammation is a key component of arterial injury, with VSMC proliferation and neointimal formation serving as the final outcomes of this process. However, the acute events transpiring immediately after arterial injury that establish the blueprint f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6bccbafbd918b35745257411433de9
https://doi.org/10.1172/jci41738
https://doi.org/10.1172/jci41738
Autor:
Kamal M. Khanna, Leo Lefrançois, Timothy Hla, Caiying Guo, Victoria A. Blaho, Shobha Thangada, Myat Lin Oo, Dong Soon Im
Publikováno v:
The Journal of Experimental Medicine
The sphingosine 1-phosphate receptor 1 (S1P(1)) promotes lymphocyte egress from lymphoid organs. Previous work showed that agonist-induced internalization of this G protein-coupled receptor correlates with inhibition of lymphocyte egress and results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e750c2fac6ac8e0ae92581aa1bee8a46
https://pubmed.ncbi.nlm.nih.gov/20584883
https://pubmed.ncbi.nlm.nih.gov/20584883