Zobrazeno 1 - 10
of 136
pro vyhledávání: '"My N. Helms"'
Autor:
Kristi J. Warren, Emily M. Beck, Sean J. Callahan, My N. Helms, Elizabeth Middleton, Sean Maddock, Jason R. Carr, Dixie Harris, Denitza P. Blagev, Michael J. Lanspa, Samuel M. Brown, Robert Paine
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Exposure to e-cigarette vapors alters important biologic processes including phagocytosis, lipid metabolism, and cytokine activity in the airways and alveolar spaces. Little is known about the biologic mechanisms underpinning the conversion
Externí odkaz:
https://doaj.org/article/d62237b9698b4213a647b3386363745c
Autor:
Tong Zhang, Nicholas J. Day, Matthew Gaffrey, Karl K. Weitz, Kwame Attah, Patrice N. Mimche, Robert Paine, III, Wei-Jun Qian, My N. Helms
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102405- (2022)
Preterm infants and patients with lung disease often have excess fluid in the lungs and are frequently treated with oxygen, however long-term exposure to hyperoxia results in irreversible lung injury. Although the adverse effects of hyperoxia are med
Externí odkaz:
https://doaj.org/article/0d8fda8689d44b0fa3425dcdb556e9d9
Autor:
Theodore G. Liou, Frederick R. Adler, Barbara C. Cahill, David R. Cox, James E. Cox, Garett J. Grant, Kimberly E. Hanson, Stephen C. Hartsell, Nathan D. Hatton, My N. Helms, Judy L. Jensen, Christiana Kartsonaki, Yanping Li, Daniel T. Leung, James E. Marvin, Elizabeth A. Middleton, Sandra M. Osburn‐Staker, Kristyn A. Packer, Salika M. Shakir, Anne B. Sturrock, Keith D. Tardif, Kristi J. Warren, Lindsey J. Waddoups, Lisa J. Weaver, Elizabeth Zimmerman, Robert Paine III
Publikováno v:
Physiological Reports, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract COVID‐19 causes severe disease with poor outcomes. We tested the hypothesis that early SARS‐CoV‐2 viral infection disrupts innate immune responses. These changes may be important for understanding subsequent clinical outcomes. We obtai
Externí odkaz:
https://doaj.org/article/cad182d307d642e6bf3b48dd61e5b619
Publikováno v:
Physiology. 38
Background: Bronchopulmonary dysplasia (BPD) is a severe oxidative-stress induced lung disease that primarily affects premature infants requiring long term oxygen supplementation. BPD is characterized by attenuated lung development, fibrosis, inflamm
Autor:
David Trac, My N. Helms
Publikováno v:
AIMS Molecular Science, Vol 4, Iss 1, Pp 28-40 (2017)
Background: Epithelial sodium channels (ENaC) play critically important roles in lung fluid clearance at birth. We have previously shown that Nadph oxidase (NOX)-derived reactive oxygen species signaling activates ENaC and promotes alveolar fluid cle
Externí odkaz:
https://doaj.org/article/b76a99dee23c4fb4acc3d610226e0482
Publikováno v:
AIMS Molecular Science, Vol 3, Iss 3, Pp 439-453 (2016)
There is considerable evidence that cigarette smoking is the primary etiology of chronic obstructive pulmonary disease (COPD), and that oxidative stress occurs in COPD with the family of tissue nicotinamide adenine dinucleotide phosphate (NADPH) oxid
Externí odkaz:
https://doaj.org/article/7601c33249464a4881aa2555bee1bd4f
Autor:
Theodore G. Liou, My N. Helms
Publikováno v:
Am J Respir Cell Mol Biol
Neutrophil extracellular traps increase cystic fibrosis (CF) airway inflammation. We hypothesized that macrophage exposure to neutrophil elastase (NE) would trigger the release of macrophage extracellular traps (METs), a novel mechanism to augment NE
Autor:
Ingrid Iara Damas, Luccas Lavareze, João Figueira Scarini, Reydson Alcides de Lima-Souza, Carolina Emerick, Mayara Trevizol Gonçalves, Tayná Figueiredo-Maciel, Gustavo de Souza Vieira, Talita de Carvalho Kimura, Iara Gonçalves Aquino, João Paulo Gonçalves de Paiva, My N. Helms, Fernanda Viviane Mariano, Albina Altemani, Erika Said Abu Egal
Publikováno v:
Placenta. 131
Villitis of unknown etiology (VUE) is an inflammatory disease characterized by the infiltration of maternal CD8 +T cells into the placental villi. Although the pathogenesis of VUE is still debated, dysregulation of the immune system appears to be an
Publikováno v:
Journal of cellular and molecular medicine. 26(14)
HMGB1 is a ubiquitously expressed protein localized in nucleus, cytoplasm, as well as secreted into extracellular space. Nuclear HMGB1 binds to DNAs and RNAs, regulating genomic stability and transcription. Cytoplasmic HMGB1 regulates autophagy throu
Publikováno v:
The FASEB Journal. 36