Zobrazeno 1 - 10
of 73
pro vyhledávání: '"My Anh Nguyen"'
Autor:
Evgenia Fadzeyeva, Cassandra A.A. Locatelli, Natasha A. Trzaskalski, My-Anh Nguyen, Megan E. Capozzi, Branka Vulesevic, Nadya M. Morrow, Peyman Ghorbani, Antonio A. Hanson, Ilka Lorenzen-Schmidt, Mary-Anne Doyle, Richard Seymour, Elodie M. Varin, Morgan D. Fullerton, Jonathan E. Campbell, Erin E. Mulvihill
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106748- (2023)
Summary: Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the
Externí odkaz:
https://doaj.org/article/213537b074c74de6ba1a3b4427a6b586
Autor:
Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not
Externí odkaz:
https://doaj.org/article/40cdcc7f6d5742ecbe16d60323de171c
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/49b1a51382684623ba8128e4be4905e1
Autor:
Elodie M. Varin, Antonio A. Hanson, Jacqueline L. Beaudry, My-Anh Nguyen, Xiemin Cao, Laurie L. Baggio, Erin E. Mulvihill, Daniel J. Drucker
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Postprandial triglycerides (TGs) are elevated in people with type 2 diabetes (T2D). Glucose-lowering agents, such as glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, also reduce postprandial TG excursio
Externí odkaz:
https://doaj.org/article/e1f3441765654638b3479d74a6662d27
Autor:
Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Linda Y. Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, Esther Mintzer, Stacy A. Maitland, Selami Demirci, John F. Tisdale, David A. Williams, Lihua Julie Zhu, Shondra M. Pruett-Miller, Luca Pinello, J. Keith Joung, Vikram Pattanayak, John P. Manis, Myriam Armant, Danilo Pellin, Christian Brendel, Scot A. Wolfe, Daniel E. Bauer
Publikováno v:
bioRxiv
SUMMARYGene editing theBCL11Aerythroid enhancer is a validated approach to fetal hemoglobin (HbF) induction for β-hemoglobinopathy therapy, though heterogeneity in edit allele distribution and HbF response may impact its safety and efficacy. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250458872ad1c0dd4644117680ac337a
https://doi.org/10.1101/2023.05.27.542323
https://doi.org/10.1101/2023.05.27.542323
Autor:
Sabrina Robichaud, Adil Rasheed, Antonietta Pietrangelo, Anne Doyoung Kim, Dominique M. Boucher, Christina Emerton, Viyashini Vijithakumar, Lara Gharibeh, Garrett Fairman, Esther Mak, My-Anh Nguyen, Michele Geoffrion, Robert Wirka, Katey J. Rayner, Mireille Ouimet
Publikováno v:
Circ Res
Rationale: Atherosclerosis is characterized by an accumulation of foam cells within the arterial wall, resulting from excess cholesterol uptake and buildup of cytosolic lipid droplets (LDs). Autophagy promotes LD clearance by freeing stored cholester
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2606
Base editing by nucleotide deaminases linked to programmable DNA-binding proteins represents a promising approach to remedy blood disorders. Here we describe the ex vivo base editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) by e
Autor:
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A. Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q. Tsai, Myriam Armant, Scot A. Wolfe, Rosalba Giugno, Daniel E. Bauer, Luca Pinello
Publikováno v:
Nat Genet
CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat disease. However, standard computational and biochemical methods to predict off-target potential focus on reference genomes. We developed an efficient tool call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a6955ae43d77107bdfe1de09e8c63a
https://hdl.handle.net/11562/1080767
https://hdl.handle.net/11562/1080767
Publikováno v:
Methods in Molecular Biology ISBN: 9781071628782
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e05f6872911fa337c23d683d9da2567a
https://doi.org/10.1007/978-1-0716-2879-9_5
https://doi.org/10.1007/978-1-0716-2879-9_5
Autor:
Andrew R. Castle, Sang-Gyun Kang, Ghazaleh Eskandari-Sedighi, Serene Wohlgemuth, My-Anh Nguyen, Daniel J. Drucker, Erin E. Mulvihill, David Westaway
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The cellular prion protein (PrP C ) converts to alternatively folded pathogenic conformations (PrP Sc ) in prion infections and binds neurotoxic oligomers formed by amyloid-β α-synuclein, and tau. β-Endoproteolysis, which splits PrP C into N- and