Cryptococcal meningoencephalitis: time for action

Autor: Stott, KE, Loyse, A, Jarvis, JN, Alufandika, M, Harrison, TS, Mwandumba, HC, Day, JN, Lalloo, DG, Bicanic, T, Perfect, JR, Hope, W

Cryptococcal meningoencephalitis was first described over a century ago. This fungal infection is preventable and treatable yet continues to be associated with excessive morbidity and mortality. The largest burden of disease resides in people living

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b14611251d3eb126443ebe48728a4309

HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy

Autor: Kelly, C, Mwandumba, HC, Heyderman, RS, Jambo, K, Kamng'ona, R, Chammudzi, M, Sheha, I, Peterseon, I, Rapala, A, Mallewa, J, Walker, AS, Klein, N, Khoo, S

Background The contribution of immune activation to arterial stiffness and its reversibility in HIV-infected adults in sub-Saharan Africa is unknown. Methods HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fb70f5d5a73e2fed5ff05d697f1d8cdc
https://doi.org/10.1093/infdis/jiz015

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Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis.

Autor: Stott KE; Antimicrobial Pharmacodynamics and Therapeutics Group, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.; Malawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi., Mohabir JT; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Bowers K; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Tenor JL; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Toffaletti DL; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Unsworth J; Antimicrobial Pharmacodynamics and Therapeutics Group, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom., Jimenez-Valverde A; Antimicrobial Pharmacodynamics and Therapeutics Group, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom., Ahmadu A; Malawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi., Moyo M; Malawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi.; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi., Gondwe E; Malawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi., Chimang'anga W; Malawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi., Chasweka M; Malawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi., Lawrence DS; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Tropical Medicine, London, United Kingdom.; Botswana Harvard Health Partnership, Gaborone, Botswana.; Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Jarvis JN; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Tropical Medicine, London, United Kingdom.; Botswana Harvard Health Partnership, Gaborone, Botswana., Harrison T; Institute of Infection and Immunity, St George's University London, London, United Kingdom., Hope W; Antimicrobial Pharmacodynamics and Therapeutics Group, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom., Lalloo DG; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Mwandumba HC; Malawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi., Perfect JR; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Cuomo CA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Publikováno v: MBio [mBio] 2024 Oct 16; Vol. 15 (10), pp. e0159224. Date of Electronic Publication: 2024 Aug 27.