Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial

Autor: Mesu, V. K. B. K., Kalonji, W. M., Rembry, S., Valverde Mordt, O., Ngolo Tete, D., Prêtre, A., Delhomme, S., Ilunga Wa Kyhi, M., Camara, M., Catusse, J., Schneitter, S., Nusbaumer, M., Mwamba Miaka, E., Mahenzi Mbembo, H., Makaya Mayawula, J., Layba Camara, M., Akwaso Massa, F., Kaninda Badibabi, L., Kasongo Bonama, A., Kavunga Lukula, P., Mutanda Kalonji, S., Mariero Philemon, P., Mokilifi Nganyonyi, R., Embana Mankiara, H., Asuka Akongo Nguba, A., Kobo Muanza, V., Mulenge Nasandhel, E., Fifi Nzeza Bambuwu, A., Scherrer, B., Strub-Wourgaft, N., Tarral, A.

Publikováno v: The Lancet. Infectious diseases.

Summary Background Human African trypanosomiasis caused by Trypanosoma brucei gambiense (gambiense HAT) in patients with late-stage disease requires hospital admission to receive nifurtimox-eflornithine combination therapy (NECT). Fexinidazole, the l

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https://pubmed.ncbi.nlm.nih.gov/36460027

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Livestock, pathogens, vectors, and their environment: A causal inference-based approach to estimating the pathway-specific effect of livestock on human African trypanosomiasis risk.

Autor: Meisner J; Center for One Health Research, University of Washington, Seattle, Washington, United States of America.; Department of Global Health, University of Washington, Seattle, Washington, United States of America., Kato A; Uganda Virus Research Institute, Entebbe, Uganda., Lemerani M; Trypanosomiasis Control Program, Ministry of Health, Lilongwe, Malawi., Mwamba Miaka E; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Kinshasa, Democratic Republic of Congo., Ismail Taban A; HISP South Sudan, Juba, South Sudan., Wakefield J; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.; Department of Statistics, University of Washington, Seattle, Washington, United States of America., Rowhani-Rahbar A; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America., Pigott DM; Department of Health Metrics Sciences, University of Washington, Seattle, Washington, United States of America., Mayer J; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America., Rabinowitz PM; Center for One Health Research, University of Washington, Seattle, Washington, United States of America.; Department of Global Health, University of Washington, Seattle, Washington, United States of America.; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America.

Publikováno v: PLOS global public health [PLOS Glob Public Health] 2023 Nov 15; Vol. 3 (11), pp. e0002543. Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2023).