RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Autor: Penn-Nicholson, A, Mbandi, SK, Thompson, E, Mendelsohn, SC, Suliman, S, Chegou, NN, Malherbe, ST, Darboe, F, Erasmus, M, Hanekom, WA, Bilek, N, Fisher, M, Kaufmann, SHE, Winter, J, Murphy, M, Wood, R, Morrow, C, Van Rhijn, I, Moody, B, Murray, M, Andrade, BB, Sterling, TR, Sutherland, J, Naidoo, K, Padayatchi, N, Walzl, G, Hatherill, M, Zak, D, Scriba, TJ, Kafaar, F, Workman, L, Mulenga, H, Hughes, EJ, Xasa, O, Veldsman, A, Cloete, Y, Abrahams, D, Moyo, S, Gelderbloem, S, Tameris, M, Geldenhuys, H, Ehrlich, R, Verver, S, Geiter, L, Black, GF, van der Spuy, G, Stanley, K, Kriel, M, Du Plessis, N, Nene, N, Roberts, T, Kleynhans, L, Gutschmidt, A, Smith, B, Loxton, AG, Tromp, G, Tabb, D, Ottenhoff, THM, Klein, MR, Haks, MC, Franken, KLMC, Geluk, A, van Meijgaarden, KE, Joosten, SA, Boom, WH, Thiel, B, Mayanja-Kizza, H, Joloba, M, Zalwango, S, Nsereko, M, Okwera, B, Kisingo, H, Parida, SK, Golinski, R, Maertzdorf, J, Weiner, J, Jacobson, M, Dockrell, H, Smith, S, Gorak-Stolinska, P, Hur, YG, Lalor, M, Lee, JS, Crampin, AC, French, N, Ngwira, B, Ben-Smith, A, Watkins, K, Ambrose, L, Simukonda, F, Mvula, H, Chilongo, F, Saul, J, Branson, K, Mahomed, H, Downing, K

Publikováno v: Scientific reports
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, 10(1):8629. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-21 (2020)
Scientific Reports, 10(1). NATURE PUBLISHING GROUP
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports, 10(1):8629. Nature Publishing Group

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72b4b335a138b78e75f4f968504b069
https://researchonline.lshtm.ac.uk/id/eprint/4656993/1/s41598-020-65043-8.pdf

Impact of monovalent rotavirus vaccine on diarrhoea-associated post-neonatal infant mortality in rural communities in Malawi: a population-based birth cohort study

Autor: Bar-Zeev, N, King, C, Phiri, T, Beard, J, Mvula, H, Crampin, AC, Heinsbroek, E, Lewycka, S, Tate, JE, Parashar, UD, Costello, A, Mwansambo, C, Heyderman, RS, French, N, Cunliffe, NA, Nakagomi, O, Verani, JR, Whitney, CG

Background: \ud Rotavirus is a major contributor to child mortality. The effect of rotavirus vaccine on diarrhoea mortality has been estimated in middle-income but not low-income settings, where mortality is high and vaccine effectiveness in reducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2da370061544e68b3fd7b90fefad16a5
https://eprints.gla.ac.uk/210146/1/210146.pdf

Cost-effectiveness of monovalent rotavirus vaccination of infants in Malawi: a postintroduction analysis using individual patient–level costing data

Autor: Bar-Zeev, N, Tate, JE, Pecenka, C, Chikafa, J, Mvula, H, Wachepa, R, Mwansambo, C, Mhango, T, Chirwa, G, Crampin, AC, Parashar, UD, Costello, A, Heyderman, RS, French, N, Atherly, D, Cunliffe, NA, Lewycka, S

Publikováno v: Clinical Infectious Diseases
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Background. Rotavirus vaccination reduces childhood hospitalization in Africa, but cost-effectiveness has not been determined using real-world effectiveness and costing data. We sought to determine monovalent rotavirus vaccine cost-effectiveness in M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be21f410b13c104e86e9977f0e817061
http://ora.ox.ac.uk/objects/uuid:

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