Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Muzhou Wu"'
Publikováno v:
JID Innovations, Vol 2, Iss 2, Pp 100090- (2022)
This past decade has seen tremendous advances in understanding the molecular pathogenesis of melanoma and the development of novel effective therapies for melanoma. Targeted therapies and immunotherapies that extend survival of patients with advanced
Externí odkaz:
https://doaj.org/article/7cc82e47b14c47bdbafcd274bb613cb3
Multimodal Metabolic Imaging Reveals Pigment Reduction and Lipid Accumulation in Metastatic Melanoma
Autor:
Hyeon Jeong Lee, Zhicong Chen, Marianne Collard, Fukai Chen, Jiaji G. Chen, Muzhou Wu, Rhoda M. Alani, Ji-Xin Cheng
Publikováno v:
BME Frontiers, Vol 2021 (2021)
Objective and Impact Statement. Molecular signatures are needed for early diagnosis and improved treatment of metastatic melanoma. By high-resolution multimodal chemical imaging of human melanoma samples, we identify a metabolic reprogramming from pi
Externí odkaz:
https://doaj.org/article/a4b76feb63ca4dc9a34de34e4f7489d4
Autor:
Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets
Externí odkaz:
https://doaj.org/article/879832a39de54eeeb00cc6a12113408e
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34933 (2012)
Multiple sclerosis (MS) is a demyelinating autoimmune disease mediated by infiltration of T cells into the central nervous system after compromise of the blood-brain barrier. We have previously shown that administration of tuftsin, a macrophage/micro
Externí odkaz:
https://doaj.org/article/231403828a294ed1af828abce24152f0
Autor:
Muzhou Wu1, Hanly, Ailish1, Gibson, Frederick1, Fisher, Robert1, Rogers, Samantha1, Kihyun Park1, Zuger, Angelina1, Kuang, Kevin1, Kalin, Jay H.2, Nocco, Sarah1, Cole, Matthew1, Xiao, Amy1, Agus, Filisia3, Labadorf, Adam3,4, Beck, Samuel1, Collard, Marianne1, Cole, Philip A.2 pacole@bwh.harvard.edu, Alani, Rhoda M.1 alani@bu.edu
Publikováno v:
Journal of Clinical Investigation. 3/15/2024, Vol. 134 Issue 6, preceding p1-21. 22p.
Autor:
Frederick Gibson, Ailish Hanly, Robert Fisher, W Austin Wyant, Muzhou Wu, Marianne Collard, Rhoda M Alani
Publikováno v:
Epigenomics. 15:167-187
Epigenetics encompasses heritable, reversible gene expression patterns that do not arise from mutations in genomic DNA but, rather, are regulated by DNA methylation, histone modifications, RNA modifications and ncRNAs; and epigenetic dysregulation is
Autor:
Rhoda M. Alani, Philip A. Cole, Byungwoo Ryu, Estela C. Gonzalez, Daniel L. Cohen, Samantha Venkatesh, Jean S. McGee, David J. Meyers, Sarah E. Nocco, Muzhou Wu, Beth E. Zucconi, Edward Kim
Histone modifications, largely regulated by histone acetyltransferases (HAT) and histone deacetylases, have been recognized as major regulatory mechanisms governing human diseases, including cancer. Despite significant effort and recent advances, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89fb2708cd78bddcdd533eec1061a73f
https://doi.org/10.1158/0008-5472.c.6510288.v1
https://doi.org/10.1158/0008-5472.c.6510288.v1
Autor:
Rhoda M. Alani, Philip A. Cole, Byungwoo Ryu, Estela C. Gonzalez, Daniel L. Cohen, Samantha Venkatesh, Jean S. McGee, David J. Meyers, Sarah E. Nocco, Muzhou Wu, Beth E. Zucconi, Edward Kim
Figures S1-S5 and Table S1. Supplementary Figure S1. p300 depletion and phenotype analysis in melanoma cell lines. Supplementary Figure S2. Molecular pathways associated with p300 in melanoma. Supplementary Figure S3. MITF is essential for melanoma s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c511af103d82b3d9d30451a938124db
https://doi.org/10.1158/0008-5472.22419093.v1
https://doi.org/10.1158/0008-5472.22419093.v1
Autor:
Frederick Gibson, Ailish Hanly, Nicole Grbic, Noah Grunberg, Muzhou Wu, Marianne Collard, Rhoda M. Alani
Publikováno v:
Clinical reviews in allergyimmunology. 63(3)
Epigenetics is the study of heritable, reversible gene expression patterns that do not originate from alterations in the DNA sequence. Epigenetic modifications influence gene expression patterns and include DNA methylation, histone modifications, and
Autor:
Beth E. Zucconi, Rhoda M. Alani, Estela Chen Gonzalez, Muzhou Wu, Daniel L. Cohen, Sarah E. Nocco, Jean S. McGee, Samantha Venkatesh, Philip A. Cole, Byungwoo Ryu, David J. Meyers, Edward Kim
Publikováno v:
Cancer Res
Histone modifications, largely regulated by histone acetyltransferases (HAT) and histone deacetylases, have been recognized as major regulatory mechanisms governing human diseases, including cancer. Despite significant effort and recent advances, the