Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: Quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile

Autor: Basha, Shaik Jafar Sadik, Naveed, Shaik Abdul, Tiwari, Nirbhay Kumar, Shashikumar, Dhanya, Muzeeb, Syed, Kumar, Thammera Ranjith, Kumar, Nyavanandi Vijay, Rao, Nadipalli Prabhakar, Srinivas, Nanduri, Mullangi, Ramesh, Srinivas, Nuggehally R.

Publikováno v: In Journal of Chromatography B 15 June 2007 853(1-2):88-96

Clinical Drug–Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives

Autor: Devaraj Venkatapura Chandrasekar, Muzeeb Syed, Suresh P. Sulochana, Ramesh Mullangi, Nuggehally R. Srinivas

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 41:469-503

Sucralfate, a complex of aluminium hydroxide with sulfated sucrose, forms a strong gastrointestinal tract (GIT) mucosal barrier with excellent anti-ulcer property. Because sucralfate does not undergo any significant oral absorption, sucralfate reside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9c7de0d771995679fb8e29516cb11c
https://doi.org/10.1007/s13318-016-0335-4

Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI)

Autor: Christian Skonberg, Muzeeb Syed, Steen Honoré Hansen

Publikováno v: Toxicology in Vitro. 31:93-102

Diclofenac is a widely prescribed NSAID, which by itself and its reactive metabolites (Phase-I and Phase-II) may be involved in serious idiosyncratic hepatotoxicity. Mitochondrial injury is one of the mechanisms of drug induced liver injury (DILI). I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a387c8def65f09b7dd677235837524b6
https://doi.org/10.1016/j.tiv.2015.11.020

Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application

Autor: Nuggehally R. Srinivas, Muzeeb Syed

Publikováno v: Journal of Pain & Palliative Care Pharmacotherapy. 30:13-24

Limited pharmacokinetic sampling strategy may be useful for predicting the area under the curve (AUC) for triptans and may have clinical utility as a prospective tool for prediction. Using appropriate intranasal pharmacokinetic data, a Cmax vs. AUC r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dd3d8240c7955be84a8eef3fde1594
https://doi.org/10.3109/15360288.2015.1124165

Applicability of a Single Time Point Strategy for the Prediction of Area Under the Concentration Curve of Linezolid in Patients:Superiority of C trough- over C max-Derived Linear Regression Models

Autor: Muzeeb Syed, Nuggehally R. Srinivas

Publikováno v: Srinivas, N R & Syed, M 2016, ' Applicability of a Single Time Point Strategy for the Prediction of Area Under the Concentration Curve of Linezolid in Patients : Superiority of C trough-over C max-Derived Linear Regression Models ', Drugs in R&D, vol. 16, no. 1, pp. 69-79 . https://doi.org/10.1007/s40268-015-0117-5
Drugs in R&D

Background and Objectives: Linezolid, a oxazolidinone, was the first in class to be approved for the treatment of bacterial infections arising from both susceptible and resistant strains of Gram-positive bacteria. Since overt exposure of linezolid ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c855d5a39c35984c9ac0c53143bb6ce5
https://curis.ku.dk/ws/files/178848353/art_3A10.1007_2Fs40268_015_0117_5.pdf