Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Muzaffer Cicek"'
Autor:
Anne Gingery, Malayannan Subramaniam, Kevin S Pitel, Jordan M Reese, Muzaffer Cicek, Laurence B Lindenmaier, James N Ingle, Matthew P Goetz, Russell T Turner, Urszula T Iwaniec, Thomas C Spelsberg, John R Hawse
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98219 (2014)
Endoxifen has recently been identified as the predominant active metabolite of tamoxifen and is currently being developed as a novel hormonal therapy for the treatment of endocrine sensitive breast cancer. Based on past studies in breast cancer cells
Externí odkaz:
https://doaj.org/article/67822f0f26c34e9d85cce6b81062378a
Autor:
John R Hawse, Malayannan Subramaniam, Muzaffer Cicek, Xianglin Wu, Anne Gingery, Sarah B Grygo, Zhifu Sun, Kevin S Pitel, Wilma L Lingle, Matthew P Goetz, James N Ingle, Thomas C Spelsberg
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54613 (2013)
Endoxifen, a cytochrome P450 mediated tamoxifen metabolite, is being developed as a drug for the treatment of estrogen receptor (ER) positive breast cancer. Endoxifen is known to be a potent anti-estrogen and its mechanisms of action are still being
Externí odkaz:
https://doaj.org/article/53b65588edee4aa2a677eafd0d4587e4
Autor:
John R Hawse, Muzaffer Cicek, Sarah B Grygo, Elizabeth S Bruinsma, Nalini M Rajamannan, Andre J van Wijnen, Jane B Lian, Gary S Stein, Merry Jo Oursler, Malayannan Subramaniam, Thomas C Spelsberg
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19429 (2011)
Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals. Calvarial osteoblasts isolated from TIEG1 knockout (K
Externí odkaz:
https://doaj.org/article/c3b2d29944cd4ce390182c32fdb11d6f
Autor:
Muzaffer Cicek, Anne Vrabel, Catherine Sturchio, Larry Pederson, John R Hawse, Malayannan Subramaniam, Thomas C Spelsberg, Merry Jo Oursler
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17522 (2011)
TGF-β Inducible Early Gene-1 (TIEG1) is a Krüppel-like transcription factor (KLF10) that was originally cloned from human osteoblasts as an early response gene to TGF-β treatment. As reported previously, TIEG1(-/-) mice have decreased cortical bon
Externí odkaz:
https://doaj.org/article/08f87d151b71472e8234f49a058e9ead
Autor:
Muzaffer Cicek, Kevin S. Pitel, Nalini M. Rajamannan, Molly Nelson Holte, Sarah G. Withers, K. Venuprasad, John R. Hawse, Elizabeth S. Bruinsma, Frank J. Secreto, Malayannan Subramaniam
Publikováno v:
Nucleic Acids Research
We have previously demonstrated that TGFβ Inducible Early Gene-1 (TIEG1), also known as KLF10, plays important roles in mediating skeletal development and homeostasis in mice. TIEG1 has also been identified in clinical studies as one of a handful of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8fe24e1aba38de8e596d4f6b14ac16
https://doi.org/10.1093/nar/gkx118
https://doi.org/10.1093/nar/gkx118
Autor:
Kevin S. Pitel, John R. Hawse, Kenneth A. Philbrick, Vera J. Suman, Russell T. Turner, Muzaffer Cicek, Farhan A. Syed, Thomas C. Spelsberg, James N. Ingle, Malayannan Subramaniam, Urszula T. Iwaniec, Kenneth D Peters, Anne Gingery
Publikováno v:
Journal of Bone and Mineral Research. 29:1206-1216
TGFβ Inducible Early Gene-1 (TIEG1) knockout (KO) mice display a sex-specific osteopenic phenotype characterized by low bone mineral density, bone mineral content, and overall loss of bone strength in female mice. We, therefore, speculated that loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df347d6f1264edf197e78b996591438b
https://doi.org/10.1002/jbmr.2142
https://doi.org/10.1002/jbmr.2142
Autor:
Xianglin Wu, Muzaffer Cicek, Malayannan Subramaniam, Carol Reynolds, Matthew P. Goetz, Vivian Negron, James N. Ingle, Wilma L. Lingle, Thomas C. Spelsberg, John R. Hawse
Publikováno v:
Journal of Cellular Biochemistry. 113:711-723
The role of estrogen receptor alpha (ERα) in breast cancer has been studied extensively, and its protein expression is prognostic and a primary determinant of endocrine sensitivity. However, much less is known about the role of ERβ and its relevanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306796b1e4317b2e123e40548657325e
https://doi.org/10.1002/jcb.23443
https://doi.org/10.1002/jcb.23443
Autor:
JN Ingle, Muzaffer Cicek, K.D. Peters, Matthew P. Goetz, Sarah B. Grygo, Kevin S. Pitel, Malayannan Subramaniam, Thomas C. Spelsberg, John R. Hawse, Xianglin Wu, Urszula T. Iwaniec, RT Turner, GL Evans
Publikováno v:
Cancer Research. 71:P3-16
Background Commonly used endocrine therapies for breast cancer, such as aromatase inhibitors in postmenopausal women and tamoxifen in premenopausal women, have deleterious effects on bone mineral density. Therefore, the identification of novel cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e2675cb6fbc2f43884e73ec5a6764ee
https://doi.org/10.1158/0008-5472.sabcs11-p3-16-09
https://doi.org/10.1158/0008-5472.sabcs11-p3-16-09
Autor:
Malayannan Subramaniam, John R. Hawse, Merry Jo Oursler, Thomas C. Spelsberg, Muzaffer Cicek, Sarah B. Grygo, Elizabeth S. Bruinsma
Publikováno v:
Biochemical and Biophysical Research Communications. 392:72-76
TGFβ inducible early gene-1 (TIEG) is a member of the Kruppel-like family of transcription factors (KLF10) that plays an important role in TGFβ mediated Smad signaling. In order to better understand the role of TIEG in bone, we generated TIEG knock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec536b3fcc0ac5d12c07c71c467a925
https://doi.org/10.1016/j.bbrc.2009.12.171
https://doi.org/10.1016/j.bbrc.2009.12.171
Autor:
Nywana Sizemore, Danny R. Welch, Mine S. Cicek, Ryuichi Fukuyama, Graham Casey, Muzaffer Cicek, Steven T. Sizemore
Publikováno v:
Clinical & Experimental Metastasis. 26:229-237
The BRMS1 metastasis suppressor was recently shown to negatively regulate NF-kappaB signaling and down regulate NF-kappaB-dependent uPA expression. Here we confirm that BRMS1 expression correlates with reduced NF-kappaB DNA binding activity in indepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1223581fd0342853587fe42942ba2a84
https://doi.org/10.1007/s10585-009-9235-1
https://doi.org/10.1007/s10585-009-9235-1