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Akademický článek

Transcriptomic Profile of Blood–Brain Barrier Remodeling in Cerebral Amyloid Angiopathy

Autor: Muyu Situ, Ali Francisco Citalan-Madrid, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by amyloid β (Aβ) peptide deposition within the walls of medium to small-caliber blood vessels, cerebral microhemorrhage, and blood–brain barrier (BBB) leakage. It is commo

Externí odkaz: https://doaj.org/article/bd1a6beb278a42199fc3104646bfb26b

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Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments

Autor: Anuska V. Andjelkovic, Muyu Situ, Ali Francisco Citalan-Madrid, Svetlana M. Stamatovic, Jianming Xiang, Richard F. Keep

Publikováno v: Stroke. 54:661-672

Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-functional interface, the blood-brain barrier (BBB). The endothelium is regulated by perivascular cells and components forming the neurovascular unit. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3280370df080b45d7328aee801886a7
https://doi.org/10.1161/strokeaha.122.040578

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A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring

Autor: Shiuan-Haur Su, Yujing Song, Andrew Stephens, Muyu Situ, Molly C. McCloskey, James L. McGrath, Anuska V. Andjelkovic, Benjamin H. Singer, Katsuo Kurabayashi

Publikováno v: Biosensors and Bioelectronics. 224:115030

Organ-on-a-chip platforms have potential to offer more cost-effective, ethical, and human-resembling models than animal models for disease study and drug discovery. Particularly, the Blood-Brain-Barrier-on-a-chip (BBB-oC) has emerged as a promising t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8facc7963ba961a7d0cd010cda1e20cc
https://doi.org/10.1016/j.bios.2022.115030

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