Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Muxiang Zhou"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Amplification of the MYCN gene leads to its overexpression at both the mRNA and protein levels. Overexpression of MYCN mRNA may also have an important role in promoting neuroblastoma (NB) beyond the translation of MYCN protein. In the present study,
Externí odkaz:
https://doaj.org/article/937dacf25a24413bba8b9ec93921e6f2
Publikováno v:
Molecular Oncology, Vol 13, Iss 5, Pp 1047-1058 (2019)
MDM4 and topoisomerase IIα (TOP2A) are overexpressed in various human cancers. MDM4 acts as an oncoprotein which promotes cancer progression by inhibiting tumor suppressor p53. As a DNA replication‐ and cell division‐regulating enzyme, TOP2A is
Externí odkaz:
https://doaj.org/article/96c1da5b27bf4e8fb241dbc751ea58fb
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100960 (2014)
Nilotinib is a selective BCR-ABL tyrosine kinase inhibitor related to imatinib that is more potent than imatinib. Nilotinib is widely used to treat chronic myelogenous leukemia (CML) and Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL).
Externí odkaz:
https://doaj.org/article/ba6136ef75f9415588585e7addad9480
Autor:
HAILONG ZHANG, Muxiang Zhou
Publikováno v:
Bio-Protocol, Vol 2, Iss 21 (2012)
During mRNA translation, 40S and 60S ribosomal subunits bind to target mRNA forming into an 80S complex (monosome). This ribosome moves along the mRNA during translational elongation to facilitate tRNA reading codon, where translation is activated an
Externí odkaz:
https://doaj.org/article/37ac72ac1ef440c4bf4cb5907ab1232e
Autor:
HAILONG ZHANG, Muxiang Zhou
Publikováno v:
Bio-Protocol, Vol 2, Iss 21 (2012)
Because covalent bond can form between RNA and its binding proteins after UV irradiation, UV cross-linking is widely used to identify the specific RNA binding proteins. This protocol is described in details as follows.
Externí odkaz:
https://doaj.org/article/40af2995a8aa45a5a363cdaea7c946d7
A novel small-molecule anthraquinone (AQ) analogue, AQ-101, which was synthesized through chemical modification of the core structures of rhein, exhibited potent anticancer activity. In the present study, we evaluated the cancer-inhibiting mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d29d74bbeb6c9c4ef3798f8cced7179
https://doi.org/10.1158/1535-7163.c.6539362.v1
https://doi.org/10.1158/1535-7163.c.6539362.v1
Supplementary Table 1, Figures 1-3, Methods from Degradation of MDM2 by the Interaction between Berberine and DAXX Leads to Potent Apoptosis in MDM2-Overexpressing Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b8f464e72e3701ab55dfe1fdeabdfd
https://doi.org/10.1158/0008-5472.22386792
https://doi.org/10.1158/0008-5472.22386792
Publikováno v:
European Journal of Medicinal Chemistry. 255:115423
Autor:
Muxiang Zhou, Zhongzhi Wu, Wei Li, Bernd Meibohm, Pradeep B. Lukka, John C. Bollinger, Tao Liu, Sicheng Zhang, Lubing Gu
Publikováno v:
J Med Chem
Murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP) are important cell survival proteins in tumor cells. As a dual MDM2/XIAP inhibitor reported previously, compound MX69 has low potency with an IC(50) value of 7.5 μM aga