Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Muwen Kong"'
Autor:
Jihyun Choi, Muwen Kong, Danielle N Gallagher, Kevin Li, Gabriel Bronk, Yiting Cao, Eric C Greene, James E Haber
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010056 (2022)
Using budding yeast, we have studied Rad51-dependent break-induced replication (BIR), where the invading 3' end of a site-specific double-strand break (DSB) and a donor template share 108 bp of homology that can be easily altered. BIR still occurs ab
Externí odkaz:
https://doaj.org/article/9b7086fc651b42c1a94cc5e31d1434a4
Autor:
Muwen Kong, Eric C. Greene
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
DNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms are responsible for the repair of DSBs, homolo
Externí odkaz:
https://doaj.org/article/abc753da62a74618b4508711a51a7895
Autor:
Eric C. Greene, Muwen Kong
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
DNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms are responsible for the repair of DSBs, homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cce3837f3a96a5a16e7cade73ea950
https://pubmed.ncbi.nlm.nih.gov/34869333
https://pubmed.ncbi.nlm.nih.gov/34869333
Publikováno v:
Journal of Visualized Experiments.
Homologous recombination (HR) is important for the repair of double-stranded DNA breaks (DSBs) and stalled replication forks in all organisms. Defects in HR are closely associated with a loss of genome integrity and oncogenic transformation in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee53e975ecf117996d6a9958f5c41ed
https://doi.org/10.3791/61320
https://doi.org/10.3791/61320
Publikováno v:
Seminars in Cell & Developmental Biology. 73:220-230
Atomic force microscopy (AFM) has made significant contributions to the study of protein-DNA interactions by making it possible to topographically image biological samples. A single protein-DNA binding reaction imaged by AFM can reveal protein bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc10d831b137223972e56d82c09c673
https://doi.org/10.1016/j.semcdb.2017.06.028
https://doi.org/10.1016/j.semcdb.2017.06.028
Publikováno v:
ChemBioChem. 18:466-469
Nucleotide excision repair (NER) is a generalized DNA repair mechanism that is capable of removing a wide variety of DNA lesions induced by physical or chemical insults. UvrD, a member of the helicase SF1 superfamily and plays an essential role in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9242d147c525875670ad991501f58a
https://doi.org/10.1002/cbic.201600624
https://doi.org/10.1002/cbic.201600624
Autor:
Namrata Kumar, Sunbok Jang, Cindy Khuu, Patricia L. Opresko, Muwen Kong, Bennett Van Houten, Elise Fouquerel, Emily C. Beckwitt, Simon C. Watkins, Sheila S. David, Chandrima Majumdar, Marcel P. Bruchez, Rajendra Prasad, Vesna Rapić-Otrin, Samuel H. Wilson
Publikováno v:
Nature structural & molecular biology, vol 26, iss 8
Nature structural & molecular biology
Nature structural & molecular biology
UV-DDB, a key protein in human global nucleotide excision repair (NER), binds avidly to abasic sites and 8-oxo-guanine (8-oxoG), suggesting a noncanonical role in base excision repair (BER). We investigated whether UV-DDB can stimulate BER for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4073e57005786b2de7cad2db34fbbf
https://escholarship.org/uc/item/55d5d9g6
https://escholarship.org/uc/item/55d5d9g6
Dynamic action of DNA repair proteins as revealed by single molecule techniques: Seeing is believing
Publikováno v:
DNA Repair (Amst)
DNA repair is a highly dynamic process in which the actual damage recognition process occurs through an amazing dance between the DNA duplex containing the lesion and the DNA repair proteins. Single molecule investigations have revealed that DNA repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89b49b5e8e57275eb18fa2e9c2b15a9
https://doi.org/10.1016/j.dnarep.2020.102909
https://doi.org/10.1016/j.dnarep.2020.102909
Autor:
Dongqing Pan, Muwen Kong, Edward P. Morris, Eric C. Greene, Andrea Musacchio, Fabienne Beuron, Alessandro Vannini, Erin E. Cutts, Thangavelu Kaliyappan, Chaoyou Xue
Publikováno v:
Molecular Cell
Summary Structural maintenance of chromosomes (SMC) complexes are essential for genome organization from bacteria to humans, but their mechanisms of action remain poorly understood. Here, we characterize human SMC complexes condensin I and II and unv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8cfe31cb9e70f3fd90ab50b81b7e9c
https://doi.org/10.1016/j.molcel.2020.04.026
https://doi.org/10.1016/j.molcel.2020.04.026
Publikováno v:
Methods in enzymology. 592
Single-molecule approaches to solving biophysical problems are powerful tools that allow static and dynamic real-time observations of specific molecular interactions of interest in the absence of ensemble-averaging effects. Here, we provide detailed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5cdd356273d44add116f8da100dbef
https://pubmed.ncbi.nlm.nih.gov/28668122
https://pubmed.ncbi.nlm.nih.gov/28668122