Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer.

Autor: Bojmar L; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Zambirinis CP; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Hernandez JM; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Chakraborty J; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shaashua L; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Kim J; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Johnson KE; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Hanna S; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Askan G; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Burman J; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Ravichandran H; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Zheng J; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jolissaint JS; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Srouji R; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Song Y; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Choubey A; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kim HS; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Cioffi M; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., van Beek E; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sigel C; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jessurun J; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Velasco Riestra P; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Blomstrand H; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Department of Clinical Pathology, Linköping University, Linköping, Sweden., Jönsson C; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Jönsson A; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Lauritzen P; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Buehring W; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Ararso Y; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Hernandez D; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Vinagolu-Baur JP; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Friedman M; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Glidden C; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Firmenich L; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Lieberman G; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Mejia DL; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Nasar N; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mutvei AP; Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden., Paul DM; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Bram Y; Division of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, NY, USA., Costa-Silva B; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Basturk O; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boudreau N; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Zhang H; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Matei IR; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Hoshino A; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA., Kelsen D; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sagi I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Scherz A; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Scherz-Shouval R; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Yarden Y; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Oren M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Egeblad M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Lewis JS; Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA., Keshari K; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Grandgenett PM; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Rajasekhar VK; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Healey JH; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Björnsson B; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Simeone DM; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA., Tuveson DA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bromberg J; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Vincent CT; Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., O'Reilly EM; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA., DeMatteo RP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Balachandran VP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., D'Angelica MI; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kingham TP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Allen PJ; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Simpson AL; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Elemento O; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Sandström P; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Schwartz RE; Division of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Jarnagin WR; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lyden D; Departments of Pediatrics and Cell and Developmental Biology, Children's Cancer and Blood Foundation Laboratories, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine, New York, NY, USA. dcl2001@med.cornell.edu.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA. dcl2001@med.cornell.edu.

Publikováno v: Nature medicine [Nat Med] 2024 Aug; Vol. 30 (8), pp. 2170-2180. Date of Electronic Publication: 2024 Jun 28.

An affinity tool for the isolation of endogenous active mTORC1 from various cellular sources.

Autor: Ibrahim YH; Araucaria Laboratories, Inc, New York, New York, USA. Electronic address: Ibrahim.y.h@araucarialabs.com., Pantelios S; Department of Immunology, Pathology and Genetics, Uppsala University, Uppsala, Sweden., Mutvei AP; Department of Immunology, Pathology and Genetics, Uppsala University, Uppsala, Sweden; Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: anders.mutvei@igp.uu.se.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 May; Vol. 299 (5), pp. 104644. Date of Electronic Publication: 2023 Mar 23.

Altered propionate metabolism contributes to tumour progression and aggressiveness.

Autor: Gomes AP; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. ana.gomes@moffitt.org.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA. ana.gomes@moffitt.org.; Department of Molecular Oncology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA. ana.gomes@moffitt.org., Ilter D; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.; Department of Molecular Oncology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA., Low V; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Drapela S; Department of Molecular Oncology, H. Lee Moffit Cancer Center & Research Institute, Tampa, FL, USA., Schild T; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mullarky E; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Han J; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Elia I; Laboratory of Cellular Metabolism and Metabolic Regulation, Vlaams Instituut voor Biotechnologie Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, Katholieke Universiteit Leuven and Leuven Cancer Institute, Leuven, Belgium., Broekaert D; Laboratory of Cellular Metabolism and Metabolic Regulation, Vlaams Instituut voor Biotechnologie Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, Katholieke Universiteit Leuven and Leuven Cancer Institute, Leuven, Belgium., Rosenzweig A; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Nagiec M; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Nunes JB; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Schaffer BE; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Mutvei AP; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Asara JM; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, Vlaams Instituut voor Biotechnologie Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, Katholieke Universiteit Leuven and Leuven Cancer Institute, Leuven, Belgium., Blenis J; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. job2064@med.cornell.edu.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA. job2064@med.cornell.edu.

Publikováno v: Nature metabolism [Nat Metab] 2022 Apr; Vol. 4 (4), pp. 435-443. Date of Electronic Publication: 2022 Mar 31.

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.

Autor: Mutvei AP; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA. anders.mutvei@igp.uu.se.; Karolinska Institutet, Department of Microbiology, Tumor and Cell biology, Nobels väg 16, KI Solna Campus Karolinska Institutet, Box 280, SE-171 77, Stockholm, Sweden. anders.mutvei@igp.uu.se.; Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85, Uppsala, Sweden. anders.mutvei@igp.uu.se., Nagiec MJ; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA., Hamann JC; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA., Kim SG; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA., Vincent CT; Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85, Uppsala, Sweden.; Department of Microbiology, New York University School of Medicine, New York, NY, USA., Blenis J; Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building, 413 E. 69th St., New York, NY, 10021, USA. jblenis@med.cornell.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Mar 17; Vol. 11 (1), pp. 1416. Date of Electronic Publication: 2020 Mar 17.

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin.

Autor: He L; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021; loh2007@med.cornell.edu jblenis@med.cornell.edu.; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021.; World Class Institute, Korea Research Institute of Bioscience and Biotechnology, 363-883 Ochang, Korea., Fei DL; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021., Nagiec MJ; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021.; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021., Mutvei AP; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021.; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021., Lamprakis A; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021.; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021., Kim BY; World Class Institute, Korea Research Institute of Bioscience and Biotechnology, 363-883 Ochang, Korea., Blenis J; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021; loh2007@med.cornell.edu jblenis@med.cornell.edu.; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 24; Vol. 116 (39), pp. 19523-19529. Date of Electronic Publication: 2019 Sep 06.