Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Mutsuo Sekiguchi"'
Autor:
Sugako Oka, Teruhisa Tsuzuki, Masumi Hidaka, Mizuki Ohno, Yoshimichi Nakatsu, Mutsuo Sekiguchi
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Oxidative stress plays a pivotal role in the differentiation and proliferation of cells and programmed cell death. However, studies on the role of oxidative stress in differentiation have mainly employed the detection of reactive oxygen spec
Externí odkaz:
https://doaj.org/article/cebd2e5d5141497baaa1a27da98bbaf1
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44817 (2012)
O⁶-Methylguanine, one of alkylated DNA bases, is especially mutagenic. Cells containing this lesion are eliminated by induction of apoptosis, associated with the function of mismatch repair (MMR) proteins. A retrovirus-mediated gene-trap mutagenesi
Externí odkaz:
https://doaj.org/article/32041a432ac944a8bde15029a1900493
Autor:
Mutsuo Sekiguchi, Takashi Ishii, Tsugumi Fujita, Hiroshi Hayakawa, Yusaku Nakabeppu, Tatsuhiro Igawa
Publikováno v:
The Journal of Biological Chemistry
J Biol Chem
J Biol Chem
PCBP1, a member of the poly(C)-binding protein (PCBP) family, has the capability of binding heavily oxidized RNA and therefore participates in the cellular response to oxidative conditions, helping to induce apoptosis. There are four other members of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a72b2d3377a9061241a044e3a769015
https://doi.org/10.1074/jbc.ra119.011870
https://doi.org/10.1074/jbc.ra119.011870
Autor:
Huanming Yang, Hai Bo Chen, Mutsuo Sekiguchi, Tie Mei Zhang, Tao Xu, Jia Lou Zhu, Samuel H. Wilson, Xiuqing Zhang, Ben Nie, Zhe Li Jiang, Jian Ye Wang, Qing He, Xiao Yang Zhou, Jian Ping Cai, Jin Li, Zhi Xin Zhang, Jian Li, Dong Ge Liu, Wei Gan, Yi Xin Zeng, Xue Da Hu, Guo-Xin Hu, Da Peng Dai, Yao Wang, Ping Ping Zuo, Yue Zhou, Hiroshi Hayakawa, Nan Yang, Li-Qun Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 115:4218-4222
Reactive oxygen species formed within the mammalian cell can produce 8-oxo-7,8-dihydroguanine (8-oxoG) in mRNA, which can cause base mispairing during gene expression. Here we found that administration of 8-oxoGTP in MTH1-knockdown cells results in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3df0e8f16b48ae2ea21e3f107d8dda1
https://doi.org/10.1073/pnas.1718363115
https://doi.org/10.1073/pnas.1718363115
Autor:
Takashi Ishii, Tatsuhiro Igawa, Hiroshi Hayakawa, Tsugumi Fujita, Mutsuo Sekiguchi, Yusaku Nakabeppu
Publikováno v:
Journal of Biological Chemistry. 297:101447
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3c6ac4be5224bcd8fa7ae3712f336c6
https://doi.org/10.1016/j.jbc.2021.101447
https://doi.org/10.1016/j.jbc.2021.101447
Autor:
Ryosuke Fujikane, Masumi Hidaka, Mihoko Rikitake, Mutsuo Sekiguchi, Yuko Obayashi, Yukimasa Takeishi
Publikováno v:
J Biol Chem
The mismatch repair (MMR) complex is composed of MutSα (MSH2-MSH6) and MutLα (MLH1-PMS2) and specifically recognizes mismatched bases during DNA replication. O6-Methylguanine is produced by treatment with alkylating agents, such as N-methyl-N-nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141fad4604ef05211120cd37a1e7550
https://pubmed.ncbi.nlm.nih.gov/31843968
https://pubmed.ncbi.nlm.nih.gov/31843968
Autor:
Masumi Hidaka, Teruhisa Tsuzuki, Michio Hayashi, Sugako Oka, Mutsuo Sekiguchi, Kenichi Taguchi
Publikováno v:
Carcinogenesis. 41(1)
Reactive oxygen species (ROS) generated during cellular respiration oxidize various cellular constituents, which cause carcinogenesis. Because most studies on the role of ROS in carcinogenesis have mainly been performed using tumor-derived cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f51251585c307245ece6bb8811b96fe
https://pubmed.ncbi.nlm.nih.gov/31058919
https://pubmed.ncbi.nlm.nih.gov/31058919
Autor:
David H. Phillips, Yusaku Nakabeppu, Agnieszka Siomek-Gorecka, Jie Zuo, Teruhisa Tsuzuki, Mark D. Evans, Margherita Bignami, Rajinder Singh, Daniel Gackowski, Mutsuo Sekiguchi, Rafal Rozalski, Alex Pines, Kunihiko Sakumi, Marcus S. Cooke, Leon H.F. Mullenders, Ryszard Olinski, Vilas Mistry
Publikováno v:
Free Radical Biology and Medicine. 99:385-391
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo) is a widely measured biomarker of oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d786cdab886e47d093cfb7ae350d13
https://doi.org/10.1016/j.freeradbiomed.2016.08.018
https://doi.org/10.1016/j.freeradbiomed.2016.08.018
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(26)
In aerobically growing cells, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG), which induces alteration in their gene expression. We previously demonstrated that the human AUF1 protein binds to 8-oxoG in RNA to induce the sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d1eb1b50cab43825c871e62d4f41ce
https://pubmed.ncbi.nlm.nih.gov/29891675
https://pubmed.ncbi.nlm.nih.gov/29891675
Publikováno v:
Free Radical Biology and Medicine. 79:109-116
In aerobically growing cells, in which reactive oxygen species are produced, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine, which induces alterations in gene expression. Here we show that the human Auf1 protein, also called HNRNPD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741dc7516e16c273e89e1682d339c9cd
https://doi.org/10.1016/j.freeradbiomed.2014.11.018
https://doi.org/10.1016/j.freeradbiomed.2014.11.018