Výsledky vyhledávání - "Mutsumi Kaminishi"

Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice

Autor: Hiromi Yanagihara, Takamitsu Morioka, Shunsuke Yamazaki, Yutaka Yamada, Hirotaka Tachibana, Kazuhiro Daino, Chizuru Tsuruoka, Yoshiko Amasaki, Mutsumi Kaminishi, Tatsuhiko Imaoka, Shizuko Kakinuma

Publikováno v: Journal of Radiation Research. 64:622-631

Recent studies have identified interstitial deletions in the cancer genome as a radiation-related mutational signature, although most of them do not fall on cancer driver genes. Pioneering studies in the field have indicated the presence of loss of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81c6ebceeb9d202dfee6de85bd3d84a3
https://doi.org/10.1093/jrr/rrad021

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High relative biological effectiveness of 2 MeV fast neutrons for induction of medulloblastoma in Ptch1+/- mice with radiation-specific deletion on chromosome 13

Autor: Chizuru, Tsuruoka, Mutsumi, Kaminishi, Mayumi, Shinagawa, Yi, Shang, Yoshiko, Amasaki, Yoshiya, Shimada, Shizuko, Kakinuma

Publikováno v: Radiation Research. 196(2):225-234

Neutron radiation, a high linear energy transfer radiation, has a high relative biological effectiveness (RBE) for various endpoints. The age at exposure is an important modifier of the effects of radiation, including carcinogenesis, with infants bei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::bb7e71edec6c6be54d816c6d371b84a4
https://repo.qst.go.jp/records/83065

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Lung-Cancer Risk in Mice after Exposure to Gamma Rays, Carbon Ions or Neutrons: Egfr Pathway Activation and Frequent Nuclear Abnormality

Autor: Kenshi Suzuki, Shunsuke Yamazaki, Ken-ichi Iwata, Yutaka Yamada, Takamitsu Morioka, Kazuhiro Daino, Mutsumi Kaminishi, Mari Ogawa, Yoshiya Shimada, Shizuko Kakinuma

Publikováno v: Radiation Research. 198

Lung is one of the high-risk organs for radiation-induced carcinogenesis, but the risk of secondary lung-cancer development after particle-beam therapy and the underlying mechanism(s) remain to be elucidated. To investigate the effects of particle-be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f1ba0978abe9f302c78874796b235b
https://doi.org/10.1667/rade-21-00192.1

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Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 ApcMin/+ Mice

Autor: Hiromi Yanagihara, Takamitsu Morioka, Shizuko Kakinuma, Masaaki Sunaoshi, Mutsumi Kaminishi, Shunsuke Yamazaki

Publikováno v: Anticancer Research. 41:1365-1375

Background/aim Progress in cancer treatment and diagnosis has made second cancer after medical radiation exposure a particular concern among childhood cancer survivors. Calorie restriction (CR) is a broadly effective cancer prevention strategy, altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cd8944e698bbdaa8b36dcd16ec9c5d1
https://doi.org/10.21873/anticanres.14894

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Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 ApcMin/+ Mice

Autor: Takamitsu, Morioka, Shunsuke, Yamazaki, Hiromi, Yanagihara, Masaaki, Sunaoshi, Mutsumi, Kaminishi, Shizuko, Kakinuma

Publikováno v: Anticancer Research. 41(3):1365-1375

Background/Aim: Progress in cancer treatment and diagnosis has made second cancer after medical radiation exposure a particular concern among childhood cancer survivors. Calorie restriction (CR) is a broadly effective cancer prevention strategy, alth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::d73d37d86ce8e50218d74d37fe5df2ad
https://repo.qst.go.jp/records/82060

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High Relative Biological Effectiveness of 2 MeV Fast Neutrons for Induction of Medulloblastoma in Ptch1+/- Mice with Radiation-specific Deletion on Chromosome 13

Autor: Chizuru Tsuruoka, Mayumi Shinagawa, Shizuko Kakinuma, Mutsumi Kaminishi, Yoshiya Shimada, Yoshiko Amasaki, Yi Shang

Publikováno v: Radiation research. 196(2)

Neutron radiation, a high-linear energy transfer radiation, has a high relative biological effectiveness (RBE) for various end points. The age at exposure is an important modifier of the effects of radiation, including carcinogenesis, with infants be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c42417131629c53da0393f09c539fc6
https://pubmed.ncbi.nlm.nih.gov/34046685

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Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1

Autor: Takamitsu, Morioka, Shunsuke, Yamazaki, Hiromi, Yanagihara, Masaaki, Sunaoshi, Mutsumi, Kaminishi, Shizuko, Kakinuma

Publikováno v: Anticancer research. 41(3)

Progress in cancer treatment and diagnosis has made second cancer after medical radiation exposure a particular concern among childhood cancer survivors. Calorie restriction (CR) is a broadly effective cancer prevention strategy, although its effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1c4c2b8115126f0f5e868a4408ebf72
https://pubmed.ncbi.nlm.nih.gov/33788728

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The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas

Autor: Yoshiya Shimada, Mayumi Nishimura, Akira Tachibana, Shinobu Hirano-Sakairi, Benjamin J. Blyth, Shizuko Kakinuma, Masaaki Sunaoshi, Mutsumi Kaminishi, Yoshiko Amasaki, Takamitsu Morioka, Yi Shang

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 779:58-67

Children are considered more sensitive to radiation-induced cancer than adults, yet any differences in genomic alterations associated with age-at-exposure and their underlying mechanisms remain unclear. We assessed genome-wide DNA copy number and mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce011796ac99db5d5c6ee02930b95b2
https://doi.org/10.1016/j.mrfmmm.2015.06.004

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Sensitive Detection of Radiation-Induced Medulloblastomas after Acute or Protracted Gamma-Ray Exposures in Ptch1 Heterozygous Mice Using a Radiation-Specific Molecular Signature

Autor: Mayumi Shinagawa, Chizuru Tsuruoka, Takamitsu Morioka, Benjamin J. Blyth, Shizuko Kakinuma, Yoshiya Shimada, Mutsumi Kaminishi

Publikováno v: Radiation research. 186(4)

Recently reported studies have led to a heightened awareness of the risks of cancer induced by diagnostic radiological imaging, and in particular, the risk of brain cancer after childhood CT scans. One feature of Ptch1+/– mice is their sensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979064f6a548af83e9bd329b2e8f7c18
https://pubmed.ncbi.nlm.nih.gov/27690174

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Genomic and gene expression signatures of radiation in medulloblastomas after low-dose irradiation in Ptch1 heterozygous mice

Autor: Mayumi Nishimura, Hiroyuki Moritake, Yoshiko Amasaki, Mutsumi Kaminishi, Yuka Ishida, Tetsu Nishikawa, Okio Hino, Toshiaki Kokubo, Seiji Kito, Yuki Ohta, Takashi Takabatake, Yoshiya Shimada, Kazutaka Doi, Kazumi Yamauchi, Shizuko Kakinuma

Publikováno v: Carcinogenesis. 31:1694-1701

Accurate cancer risk assessment of low-dose radiation poses many challenges that are partly due to the inability to distinguish radiation-induced tumors from spontaneous ones. To elucidate characteristic features of radiation-induced tumors, we analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a955344d652550fec81c7f0191e638
https://doi.org/10.1093/carcin/bgq145

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