Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Mutsuko Hara"'
Autor:
Moe Matsuzawa, Tomoaki Ando, Saaya Fukase, Meiko Kimura, Yasuharu Kume, Takuma Ide, Kumi Izawa, Ayako Kaitani, Mutsuko Hara, Eri Nakamura, Anna Kamei, Akira Matsuda, Nobuhiro Nakano, Keiko Maeda, Norihiro Tada, Hideoki Ogawa, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.
Externí odkaz:
https://doaj.org/article/ae591070ee1148c581bcc54f2ff35511
Autor:
Takuya Yashiro, Machiko Yamamoto, Sanae Araumi, Mutsuko Hara, Kyoko Yogo, Koichiro Uchida, Kazumi Kasakura, Chiharu Nishiyama
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is restricted
Externí odkaz:
https://doaj.org/article/f65d204ef6f140f4aee9ea54b13ae8a0
Autor:
Takahiro Kawauchi, Kayoko Ishimaru, Yuki Nakamura, Nobuhiro Nakano, Mutsuko Hara, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Atsuhito Nakao
Publikováno v:
Allergology International, Vol 66, Iss 3, Pp 472-478 (2017)
Background: Interleukin-33 (IL-33) is an alarmin cytokine that binds to the interleukin 1 receptor-like 1 protein ST2. Clock is a key circadian gene that is essential for endogenous clockworks in mammals. This study investigated whether Clock tempora
Externí odkaz:
https://doaj.org/article/a4cb455ce2e74873bf3e4ab6b57271a9
Autor:
Mayu Suzuki, Mutsuko Hara, Saori Ichikawa, Seiji Kamijo, Takuya Nakazawa, Hideki Hatanaka, Kazuo Akiyama, Hideoki Ogawa, Ko Okumura, Toshiro Takai
Publikováno v:
Allergology International, Vol 65, Iss 1, Pp 44-51 (2016)
Background: Patients with house dust mite (HDM) allergy or Ascariasis produce serum IgE specific to the antigens of HDM or nematode Ascaris, respectively. Although human IgE cross-reactivity has been reported between HDM and Ascaris antigens, it rema
Externí odkaz:
https://doaj.org/article/7dbdc9dbf354436a8897e8fd194c4096
Autor:
Kentaro Ishiyama, Takuya Yashiro, Nobuhiro Nakano, Kazumi Kasakura, Ryosuke Miura, Mutsuko Hara, Fumitaka Kawai, Keiko Maeda, Naoto Tamura, Ko Okumura, Hideoki Ogawa, Yoshinari Takasaki, Chiharu Nishiyama
Publikováno v:
Allergology International, Vol 64, Iss 3, Pp 241-247 (2015)
Background: The transcription factors NFATc1 and PU.1 play important roles in osteoclast development. NFATc1 and PU.1 transactivate osteoclast-specific gene expression and a deficiency in NFATc1 or PU.1 genes causes osteopetrosis due to an insufficie
Externí odkaz:
https://doaj.org/article/f3fb32bc379441cb8a8f74a04c17c6ce
Autor:
Ryosuke Miura, Kazumi Kasakura, Nobuhiro Nakano, Mutsuko Hara, Keiko Maeda, Ko Okumura, Hideoki Ogawa, Takuya Yashiro, Chiharu Nishiyama
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154094 (2016)
The cofactor CIITA is a master regulator of MHC class II expression and several transcription factors regulating the cell type-specific expression of CIITA have been identified. Although the MHC class II expression in plasmacytoid dendritic cells (pD
Externí odkaz:
https://doaj.org/article/a2ea1a9274ca484aa642497dd616ba90
Autor:
Yosuke Baba, Keiko Maeda, Takuya Yashiro, Eisuke Inage, Frangois Niyonsaba, Mutsuko Hara, Ryuyo Suzuki, Yoshikazu Ohtsuka, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Chiharu Nishiyama
Publikováno v:
Allergology International, Vol 61, Iss 3, Pp 461-467 (2012)
Background: The human IL1RL1/ST2 gene encodes IL33 receptor. Recently, IL33 has been recognized as a key molecule for the development of Th2 response. Although mast cells and basophils are major targets of IL33 and play important roles in IL33-mediat
Externí odkaz:
https://doaj.org/article/4e1879862f854b15963ab588986c68b6
Autor:
Yoko Aihara, Kyoko Oh-oka, Naoki Kondo, Jyoti Sharma, Narayan C. Shrestha, Kayoko Ishimaru, Mutsuko Hara, Zentaro Yamagata, Atsuhito Nakao
Publikováno v:
Allergology International, Vol 63, Iss 2, Pp 283-285 (2014)
Externí odkaz:
https://doaj.org/article/1a0e17b8aa76489b80535004b869a555
Autor:
Mutsuko Hara, Shingo Kinoshita, Kazuhiro Mitsumura, Kazue Hida, Masami Osaki, Eikichi Tokunaga, Akio Hatanaka
Publikováno v:
Practica Oto-Rhino-Laryngologica. 116:435-439
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7048aecf881029a4b364566ddf78fe5b
https://doi.org/10.5631/jibirin.116.435
https://doi.org/10.5631/jibirin.116.435
Autor:
Kazuki Nagata, Sanae Araumi, Daisuke Ando, Naoto Ito, Miki Ando, Yuki Ikeda, Miki Takahashi, Sakura Noguchi, Yayoi Yasuda, Nobuhiro Nakano, Tomoaki Ando, Mutsuko Hara, Takuya Yashiro, Masakazu Hachisu, Chiharu Nishiyama
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5997
In the present study, we evaluated the effects of kaempferol on bone marrow-derived mast cells (BMMCs). Kaempferol treatment significantly and dose-dependently inhibited IgE-induced degranulation, and cytokine production of BMMCs under the condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17bf2b1894b96b4d5a7200cb390f6e8