Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Mutsuhito Ohno"'
Autor:
Takashi Iezaki, Tetsuhiro Horie, Kazuya Fukasawa, Makoto Kitabatake, Yuka Nakamura, Gyujin Park, Yuki Onishi, Kakeru Ozaki, Takashi Kanayama, Manami Hiraiwa, Yuka Kitaguchi, Katsuyuki Kaneda, Takayuki Manabe, Yasuhito Ishigaki, Mutsuhito Ohno, Eiichi Hinoi
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Summary: The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs
Externí odkaz:
https://doaj.org/article/a74140fb7e634b20b5faa27345d65c2c
Autor:
Dan O. Wang, Kensuke Ninomiya, Chihiro Mori, Ayako Koyama, Martine Haan, Makoto Kitabatake, Masatoshi Hagiwara, Kazuhiro Chida, Shin-Ichiro Takahashi, Mutsuhito Ohno, Naoyuki Kataoka
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
RNA transport and regulated local translation play critically important roles in spatially restricting gene expression in neurons. Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in t
Externí odkaz:
https://doaj.org/article/c88a20d712b542bb920e3da4fc941ed3
Autor:
So Masaki, Rei Yoshimoto, Daisuke Kaida, Asuka Hata, Takayuki Satoh, Mutsuhito Ohno, Naoyuki Kataoka
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 3705-3721 (2015)
In eukaryotes, pre-mRNA splicing is an essential step for gene expression. We have been analyzing post-splicing intron turnover steps in higher eukaryotes. Here, we report protein interaction between human Debranching enzyme 1 (hDbr1) and several fac
Externí odkaz:
https://doaj.org/article/24c06fea0d44411aa7a0e58f5d97afa3
Publikováno v:
Nucleic Acids Research. 51:1393-1408
In eukaryotic cells, various classes of RNAs are exported to the cytoplasm by class-specific factors. Accumulating evidence has shown that export factors affect the fate of RNA, demonstrating the importance of proper RNA classification upon export. W
The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response
Publikováno v:
RNA
PHAX (phosphorylated adaptor for RNA export) promotes nuclear export of short transcripts of RNA polymerase II such as spliceosomal U snRNA precursors, as well as intranuclear transport of small nucleolar RNAs (snoRNAs). However, it remains unknown w
Publikováno v:
Genes to cells : devoted to molecularcellular mechanismsREFERENCES. 26(1)
Primary RNA transcripts are processed in a plethora of ways to become mature functional forms. In one example, human spliceosomal U snRNAs are matured at their 3'-end by an exonuclease termed TOE1. This process is important because mutations in TOE1
Autor:
Manami Hiraiwa, Makoto Kitabatake, Katsuyuki Kaneda, Takayuki Manabe, Gyujin Park, Takashi Iezaki, Yuka Kitaguchi, Kazuya Fukasawa, Mutsuhito Ohno, Eiichi Hinoi, Takashi Kanayama, Yuki Onishi, Tetsuhiro Horie, Yuka Nakamura, Yasuhito Ishigaki, Kakeru Ozaki
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Summary The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs/
Autor:
Makoto Kitabatake, Shogo Oka, Makoto Tomioka, Hiromu Takematsu, Yasunori Kozutsumi, Mitsugu Shimobayashi, Mutsuhito Ohno
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Cellular translation should be precisely controlled in response to extracellular cues. However, knowledge is limited concerning signal transduction-regulated translation. In the present study, phosphorylation was identified in the 40S small subunit r
Publikováno v:
Mol Cell Biol
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long noncoding RNA that functions as an essential framework of subnuclear paraspeckle bodies. Of the two isoforms (NEAT1_1 and NEAT1_2) produced by alternative 3'-end RNA processing, the longer i
Publikováno v:
Genes to Cells. 21:1263-1269
Localization of mRNA in neuronal cells is a critical process for spatiotemporal regulation of gene expression. Cytoplasmic localization of mRNA is often conferred by transport elements in 3' untranslated region (UTR). Activity-regulated cytoskeleton-