Výsledky vyhledávání - "Mutsa Tatenda Madondo"

Akademický článek

Interleukin 6 Present in Inflammatory Ascites from Advanced Epithelial Ovarian Cancer Patients Promotes Tumor Necrosis Factor Receptor 2-Expressing Regulatory T Cells

Autor: Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, Orla M. McNally, Andrew N. Stephens, Michael A. Quinn, Magdalena Plebanski

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

BackgroundEpithelial ovarian cancer (EOC) remains a highly lethal gynecological malignancy. Ascites, an accumulation of peritoneal fluid present in one-third of patients at presentation, is linked to poor prognosis. High levels of regulatory T cells

Externí odkaz: https://doaj.org/article/0dd567c94a494a328b2b4eed54f0b86a

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Combining TNFR2-Expressing Tregs and IL-6 as Superior Diagnostic Biomarkers for High-Grade Serous Ovarian Cancer Masses

Autor: Nirmala Chandralega Kampan, Apriliana Ellya Ratna Kartikasari, Cyril Deceneux, Mutsa Tatenda Madondo, Orla M. McNally, Katie Louise Flanagan, Norhaslinda A. Aziz, Andrew N. Stephens, John Reynolds, Michael A. Quinn, Magdalena Plebanski

Publikováno v: Cancers
Volume 15
Issue 3
Pages: 667

We hypothesised that the inclusion of immunosuppressive and inflammatory biomarkers in HGSOC patients would improve the sensitivity and specificity of the preoperative marker prediction of malignancy in patients with ovarian masses. We tested a panel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809c9319f16dc197ea5079f5063dfa28

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Sperm Protein 17 Expression by Murine Epithelial Ovarian Cancer Cells and Its Impact on Tumor Progression

Autor: Mutsa Tatenda Madondo, Qian Gao, Magdalena Plebanski, Sue D. Xiang, Andrew N. Stephens, Kirsty Wilson

Publikováno v: Cancers, Vol 10, Iss 8, p 276 (2018)
Cancers
Volume 10
Issue 8

The cancer testis antigen sperm protein 17 (Sp17) is a promising antigenic target in epithelial ovarian cancer (EOC) vaccine development. However, its role in ovarian cancer is unclear. We isolated and expanded Sp17+ and Sp17&minus
clones from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4601c90d469e04f0d562a1bf7cc8d638
http://www.mdpi.com/2072-6694/10/8/276

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Lenalidomide-based maintenance therapy reduces TNF receptor 2 on CD4 T cells and enhances immune effector function in acute myeloid leukemia patients

Autor: Peter J. Tan, Andrew H. Wei, Mutsa Tatenda Madondo, Ying Ying Kong, Magdalena Plebanski, Chindu Govindaraj

Publikováno v: American Journal of Hematology. 89:795-802

A major limitation to improved outcomes in acute myelogenous leukemia (AML) is relapse resulting from leukemic cells that persist at clinical remission. Regulatory T cells (Tregs), which are increased in AML patients, can contribute to immune evasion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0459b112ebd3a0e8e11a3f29326c5930
https://doi.org/10.1002/ajh.23746

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Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment

Autor: Michael A. Quinn, Katie L. Flanagan, Karen Scalzo-Inguanti, Julene Hallo, Chindu Govindaraj, Mutsa Tatenda Madondo, Magdalena Plebanski

Publikováno v: Clinical Immunology. 149:97-110

Ovarian cancer is a prevalent gynecological malignancy with potent immune-suppression capabilities; regulatory T cells (Tregs) are significant contributors to this immune-suppression. As ovarian cancer patients present with high levels of TNF and Tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d9972d045724f4b70a94f98c855f18
https://doi.org/10.1016/j.clim.2013.07.003

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Low dose cyclophosphamide: Mechanisms of T cell modulation

Autor: Mutsa Tatenda Madondo, Michael A. Quinn, Magdalena Plebanski

Publikováno v: Cancer treatment reviews. 42

Cyclophosphamide is considered one of the most successful chemotherapy drugs and is listed on the World Health Organisations List of Essential Medicines. Since its initial synthesis in 1958, it has been widely used to treat a range of cancers but its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b6787ad874b06732fd7a2ccf7d890b
https://pubmed.ncbi.nlm.nih.gov/26620820

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Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

Publikováno v: Immunity
Immunity, 2016, 45 (4), pp.931-943. ⟨10.1016/j.immuni.2016.09.009⟩
Immunity, Elsevier, 2016, 45 (4), pp.931-943. ⟨10.1016/j.immuni.2016.09.009⟩
Immunity, Elsevier, 2016, 45 (4), pp.931-943. 〈http://www.sciencedirect.com/science/article/pii/S1074761316303788〉. 〈10.1016/j.immuni.2016.09.009〉

International audience; The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are involved in tumor immunosurveillance, and their mechanism of action are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defd71ad3cc9c8f2e9b092eee25ae8e6
https://pubmed.ncbi.nlm.nih.gov/27760335

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Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer

Autor: Michael A. Quinn, Nirmala Chandralega Kampan, Orla McNally, Magdalena Plebanski, Mutsa Tatenda Madondo

Publikováno v: BioMed Research International, Vol 2015 (2015)
BioMed Research International

Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91617d1c879451a0ac6eb6074badec1e
https://doaj.org/article/8b6e64a69fd34ddca95cdc05f9c8c582

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