Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Muthusamy Thangaraju"'
Autor:
Huabin Zhu, Anuj K. Sharma, Karina Aguilar, Faizan Boghani, Semih Sarcan, Michelle George, Janavi Ramesh, Joshua Van Der Eerden, Chandramukhi S. Panda, Aileen Lopez, Wenbo Zhi, Roni Bollag, Nikhil Patel, Kandace Klein, Joe White, Muthusamy Thangaraju, Bal L. Lokeshwar, Nagendra Singh, Vinata B. Lokeshwar
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109191- (2024)
Summary: The paucity of preclinical models that recapitulate COVID-19 pathology without requiring SARS-COV-2 adaptation and humanized/transgenic mice limits research into new therapeutics against the frequently emerging variants-of-concern. We develo
Externí odkaz:
https://doaj.org/article/3877c862934c43f0957472d97369ba13
Autor:
Jiaojiao Wang, Andre R. Jordan, Huabin Zhu, Sarrah L. Hasanali, Eric Thomas, Soum D. Lokeshwar, Daley S. Morera, Sung Alexander, Joseph McDaniels, Anuj Sharma, Karina Aguilar, Semih Sarcan, Tianyi Zhu, Mark S. Soloway, Martha K. Terris, Muthusamy Thangaraju, Luis E. Lopez, Vinata B. Lokeshwar
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-18 (2022)
Abstract Background Hyaluronic acid (HA) promotes cancer metastasis; however, the currently approved treatments do not target HA. Metastatic renal carcinoma (mRCC) is an incurable disease. Sorafenib (SF) is a modestly effective antiangiogenic drug fo
Externí odkaz:
https://doaj.org/article/1f1a172dc33d4a4c9e1a7d3503729931
Publikováno v:
Molecules, Vol 27, Iss 24, p 8981 (2022)
Ursolic acid (UA) is a pentacyclic triterpene isolated from a large variety of vegetables, fruits and many traditional medicinal plants. It is a structural isomer of Oleanolic Acid. The medicinal application of UA has been explored extensively over t
Externí odkaz:
https://doaj.org/article/a1551a5526804b21ae62de9739db132d
Autor:
Yangzom D. Bhutia, Jiro Ogura, Paul J. Grippo, Carolina Torres, Toshihiro Sato, Mitchell Wachtel, Sabarish Ramachandran, Ellappan Babu, Sathish Sivaprakasam, Devaraja Rajasekaran, Bradley Schniers, Nhu On, Logan Smoot, Muthusamy Thangaraju, Jaya P. Gnana-Prakasam, Vadivel Ganapathy
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 2, Pp 237-251 (2020)
Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pan
Externí odkaz:
https://doaj.org/article/fa207eb435da45528dce5dad9ee9ba3b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector func
Externí odkaz:
https://doaj.org/article/ffaacd0e261f464d9be0c36cf7942ac0
Autor:
Siva S. Panda, Queen L. Tran, Pragya Rajpurohit, Girinath G. Pillai, Sean J. Thomas, Allison E. Bridges, Jason E. Capito, Muthusamy Thangaraju, Bal L. Lokeshwar
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 451 (2022)
Curcumin (CUR) has received great attention over the past two decades due to its anticancer, anti-inflammatory, and antioxidant properties. Similarly, Dichloroacetate (DCA), an pyruvate dehydrogenase kinase 1 (PKD1) inhibitor, has gained huge attenti
Externí odkaz:
https://doaj.org/article/80cceee1da974436be064b13a59d0cde
Autor:
Maria Ouzounova, Eunmi Lee, Raziye Piranlioglu, Abdeljabar El Andaloussi, Ravindra Kolhe, Mehmet F. Demirci, Daniela Marasco, Iskander Asm, Ahmed Chadli, Khaled A. Hassan, Muthusamy Thangaraju, Gang Zhou, Ali S. Arbab, John K. Cowell, Hasan Korkaya
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Myeloid-derived suppressive cells (MDSCs) promote metastasis. Here, the authors show that the monocytic MDSCs subset promotes epithelial to mesenchymal transition at the primary site while the granulocytic subset promotes the reverse transition at th
Externí odkaz:
https://doaj.org/article/fd3befe0433a4fdaa9773cbb10f54358
Autor:
Sudha Ananth, Seiji Miyauchi, Muthusamy Thangaraju, Ravirajsinh N. Jadeja, Manuela Bartoli, Vadivel Ganapathy, Pamela M. Martin
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 9 (2020)
Oxidative damage has been identified as a major causative factor in degenerative diseases of the retina; retinal pigment epithelial (RPE) cells are at high risk. Hence, identifying novel strategies for increasing the antioxidant capacity of RPE cells
Externí odkaz:
https://doaj.org/article/e87aa7a9230d4a9da90506a0ed6217b9
Autor:
Indumathi Manoharan, Daniel Swafford, Arulkumaran Shanmugam, Nikhil Patel, Puttur D. Prasad, Riyaz Mohamed, Qingqing Wei, Zheng Dong, Muthusamy Thangaraju, Santhakumar Manicassamy
Publikováno v:
The Journal of Immunology. 209:368-378
Extraintestinal manifestations are common in inflammatory bowel disease and involve several organs, including the kidney. However, the mechanisms responsible for renal manifestation in inflammatory bowel disease are not known. In this study, we show
Autor:
Huidong Shi, David H. Munn, Shou-Ching Tang, Stefan Ambs, Arun Sreekumar, Muthusamy Thangaraju, Shuang Huang, Hong-Bo Xin, Libin Deng, Hasan Korkaya, Tim H.M. Huang, Katie Chiou, Jiseok Choi, Fang Shi, Ravindra Kolhe, Pei-Yin Hsu, Lirong Pei, Austin Y. Shull, Maria Ouzounova, Jaejik Kim, Qimei Han, Jeong-Hyeon Choi, Eun-Joon Lee, Franklin Gu, Satish K. Noonepalle
Supplementary Table 1: List of primers used for quantitative real time PCR. Supplementary Table. 2: List of primers used for construction of pGL2 and pMIR reporter plasmids. Supplementary Table. 3: List of primers used to generate PCR amplicons for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fed68c14a16cfbab8a3970f33ff2b3
https://doi.org/10.1158/2326-6066.22538461.v1
https://doi.org/10.1158/2326-6066.22538461.v1