Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Muthulekha, Swamydas"'
Autor:
Ehsan Malek, Priyanka S. Rana, Muthulekha Swamydas, Michael Daunov, Masaru Miyagi, Elena Murphy, James J. Ignatz-Hoover, Leland Metheny, Seong Jin Kim, James J. Driscoll
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Functional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov., NCT03143985) to determine the primary end
Externí odkaz:
https://doaj.org/article/2986c29d1e41419b91ddff1528ad8605
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-17 (2022)
Abstract Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of malignant plasma cells nurtured within a permissive bone marrow microenvironment. While patients mount numerous adaptive immune responses directed against th
Externí odkaz:
https://doaj.org/article/283eab1ea8d14ef384b8795692d76d60
Autor:
Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S.P. Viall, Christa S. Zerbe, Elise M.N. Ferré, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomyc
Externí odkaz:
https://doaj.org/article/71c653dd808145c48e7e7ce5ab2b01ae
Autor:
Caio C. B. Bomfim, Logan Fisher, Eduardo P. Amaral, Lara Mittereder, Katelyn McCann, André A. S. Correa, Sivaranjani Namasivayam, Muthulekha Swamydas, Mahtab Moayeri, Jonathan M. Weiss, Raj Chari, Daniel W. McVicar, Diego L. Costa, Maria R. D’Império Lima, Alan Sher
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in Mycob
Externí odkaz:
https://doaj.org/article/829c533eabff4b7a98e063262dae07c5
Autor:
Jigar V. Desai, Dhaneshwar Kumar, Tilo Freiwald, Daniel Chauss, Melissa D. Johnson, Michael S. Abers, Julie M. Steinbrink, John R. Perfect, Barbara Alexander, Vasiliki Matzaraki, Brendan D. Snarr, Marissa A. Zarakas, Vasileios Oikonomou, Lakmali M. Silva, Raju Shivarathri, Emily Beltran, Luciana Negro Demontel, Luopin Wang, Jean K. Lim, Dylan Launder, Heather R. Conti, Muthulekha Swamydas, Micah T. McClain, Niki M. Moutsopoulos, Majid Kazemian, Mihai G. Netea, Vinod Kumar, Jörg Köhl, Claudia Kemper, Behdad Afzali, Michail S. Lionakis
Publikováno v:
Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e037211b127e3f8a93eb9c17acc98d3
https://doi.org/10.1016/j.cell.2023.04.031
https://doi.org/10.1016/j.cell.2023.04.031
Autor:
Ofer Zimmerman, Lindsey B. Rosen, Muthulekha Swamydas, Elise M. N. Ferre, Mukil Natarajan, Frank van de Veerdonk, Steven M. Holland, Michail S. Lionakis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare primary immunodeficiency disorder typically caused by biallelic autoimmune regulator (AIRE) mutations that manifests with chronic mucocutaneous candidiasis (CMC) and au
Externí odkaz:
https://doaj.org/article/b2b1458cb3b740d3acfdc1a6ca57be98
Autor:
Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis, Jean K. Lim, Marisa Goff, Nathaniel D. Albert, Michail S. Lionakis, Muthulekha Swamydas, Prema Robinson, Sebastian Wurster
Publikováno v:
J Infect Dis
Pharmacological immune checkpoint blockade has revolutionized oncological therapies, and its remarkable success has sparked interest in expanding checkpoint inhibitor therapy in infectious diseases. Herein, we evaluated the efficacy of programmed cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15efcf6ad3987c6cc492b28cf2452ac7
https://doi.org/10.1093/infdis/jiaa264
https://doi.org/10.1093/infdis/jiaa264
Autor:
Naohito Ohno, Kazushiro Takatsu, Masahiro Kimura, Michail S. Lionakis, Fumitaka Oyama, Hiroaki Ohnishi, Takashi Umeyama, Muthulekha Swamydas, Daisuke Yamanaka
Publikováno v:
The Journal of Biological Chemistry
β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horsesh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8b921044f562901ee991b13ec57f46
https://doi.org/10.1074/jbc.ra119.011851
https://doi.org/10.1074/jbc.ra119.011851
Autor:
Rebecca A Drummond, Amanda L Collar, Muthulekha Swamydas, Carlos A Rodriguez, Jean K Lim, Laura M Mendez, Danielle L Fink, Amy P Hsu, Bing Zhai, Hatice Karauzum, Constantinos M Mikelis, Stacey R Rose, Elise M N Ferre, Lynne Yockey, Kimberly Lemberg, Hye Sun Kuehn, Sergio D Rosenzweig, Xin Lin, Prashant Chittiboina, Sandip K Datta, Thomas H Belhorn, Eric T Weimer, Michelle L Hernandez, Tobias M Hohl, Douglas B Kuhns, Michail S Lionakis
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005293 (2015)
Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in the C-type lectin pathway adaptor protein CARD9 develop spontaneous fungal disease that targets t
Externí odkaz:
https://doaj.org/article/099f504b30074aaf88ba805ec83e4484
Autor:
Heather D. Hickman, Chyi-Chia Richard Lee, Peter Olbrich, Jean K. Lim, Daniel Chauss, Vasileios Oikonomou, Daniel L. Barber, Philip M. Murphy, Monica M. Schmitt, Tilo Freiwald, Marc Swidergall, Stefania Pittaluga, Steven M. Holland, Daniel Martin, Luigi D. Notarangelo, Oliver J. Harrison, Scott G. Filler, Lindsey B. Rosen, Ian A. Myles, Wint Lwin, Sergio M. Pontejo, Behdad Afzali, Timothy J. Break, Niki M. Moutsopoulos, Vincent M. Bruno, Julie Alejo, Jigar V. Desai, Nicolas Bouladoux, Elise M. N. Ferré, Norma V. Solis, Mitsuru Matsumoto, David V. Serreze, Yasmine Belkaid, Andy Renteria, John P. Shannon, Nicolas Dutzan, Teresa Greenwell-Wild, Michail S. Lionakis, Drake W. Williams, Kevin W. Hoffman, Muthulekha Swamydas, Mark S. Anderson
Publikováno v:
Science
Puel and Casanova and Kisand et al . challenge our conclusions that interferonopathy and not IL-17/IL-22 autoantibodies promote candidiasis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy. We acknowledge that conclusive evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bd750b46b166f72e63ce6283b9b80c
https://pubmed.ncbi.nlm.nih.gov/34529474
https://pubmed.ncbi.nlm.nih.gov/34529474