Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Muthukumar, Elangovan"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Age-related macular degeneration (AMD) is one of the major causes of blindness in the elderly worldwide. Anti-vascular endothelial growth factor (VEGF) drugs have been widely used to treat the neovascular type of AMD (nAMD). However, VEGF ac
Externí odkaz:
https://doaj.org/article/4cae304e84494cab8576be25bb201079
Autor:
Sung Bin Kim, Bo-Ram Mun, Sung Yoon Kim, Muthukumar Elangovan, Euy Jun Park, Won-Seok Choi, Woo Jin Park
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Excessive accumulation of amyloid-β (Aβ) has been associated with the pathogenesis of Alzheimer’s disease (AD). Clinical studies have further proven that elimination of Aβ can be a viable therapeutic option. In the current study, we conceptualiz
Externí odkaz:
https://doaj.org/article/9ff45f08edbc4c53b6c59c7b2c1e3e29
Autor:
Muthukumar Elangovan, Jun Ka, Boryeong Pak, Woosoung Choi, Se‐Ra Oh, Suk‐Won Jin, Yung Joon Yoo
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(1)
Ubiquitination has been shown to provide an essential regulatory role in modulating the duration and amplitude of the signaling activity in angiogenesis. While successive enzymatic reactions mediated by three distinct types of enzymes commonly known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425c0d6e3973876f2bfd923d3bbb3fd6
https://pubmed.ncbi.nlm.nih.gov/34921695
https://pubmed.ncbi.nlm.nih.gov/34921695
Autor:
Muthukumar, Elangovan1, Elakkumanan, Lenin Babu1 dr.lenin@gmail.com, Bidkar, Prasanna Udupi1, Satyaprakash, M. V. S.1, Mishra, Sandeep Kumar1
Publikováno v:
Indian Journal of Anaesthesia. Jan2017, Vol. 61 Issue 1, p36-41. 6p.
Publikováno v:
Journal of Cell Communication and Signaling. 11:265-273
The human Ube2j1 and Ube2j2 are the only ubiquitin-conjugating enzymes (E2s) that are localized to endoplasmic reticulum (ER) through its C-terminal transmembrane domains. Ube2j1 is a known substrate of MAPK signalling pathway and it is phosphorylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8ec7ee84557031476def4fbe31c208
https://doi.org/10.1007/s12079-017-0386-6
https://doi.org/10.1007/s12079-017-0386-6
Publikováno v:
Biochemical and Biophysical Research Communications. 469:891-896
Ubiquitination is a key regulatory mechanism in the immune deficiency (IMD) pathway in Drosophila. In this study, we first developed a simple immunoblot method to identify components involved in this pathway. Considering the emerging roles of ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc7fe98d0ed10ec4054378fe87da016
https://doi.org/10.1016/j.bbrc.2015.12.062
https://doi.org/10.1016/j.bbrc.2015.12.062
Publikováno v:
Biochemical and Biophysical Research Communications. 396:425-428
It is well known that S5a and hRpn13 are two major ubiquitin (Ub) receptors in the proteasome but little is known about their functional difference in recruiting ubiquitinated substrates. In this study using siRNA-mediated knockdown of S5a or hRpn13,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2ae539a9b72aa2b191be284d28ef55
https://doi.org/10.1016/j.bbrc.2010.04.108
https://doi.org/10.1016/j.bbrc.2010.04.108
Publikováno v:
Biochemical and biophysical research communications. 388(4)
It has been demonstrated that ubiquitin-conjugated proteins were accumulated by ectopically-expressed S5a as well as the ubiquitin-interacting motifs of S5a (S5a-UIMs). In this study, we further found that free S5a-UIMs stabilized only a subset of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580387519988740be6c24fba813b673a
https://pubmed.ncbi.nlm.nih.gov/19695230
https://pubmed.ncbi.nlm.nih.gov/19695230
Autor:
Yung Joon Yoo, Muthukumar Elangovan
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3df34ed003a42da9ed8203701cb9446
https://doi.org/10.1096/fasebj.22.1_supplement.793.2
https://doi.org/10.1096/fasebj.22.1_supplement.793.2
Publikováno v:
Biochemical and biophysical research communications. 364(2)
The subunit S5a is a key component for the recruitment of ubiquitinated substrates to the 26S proteasome. When the full-length S5a, the N-terminal half of S5a (S5aN) containing the von Willebrand A (vWA) domain, and the C-terminal half of S5a (S5aC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91cb5c5c5f2f1e779a0146e7d45f7ee
https://pubmed.ncbi.nlm.nih.gov/17949686
https://pubmed.ncbi.nlm.nih.gov/17949686