Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Muthu Selvakumaran"'
Figure S1. Oligonucleotide pairs containing portions of human JNK1 and JNK2 were used to create retroviral vectors for delivery of shRNAs into HT29 cells. Target sequences (underlined) were taken from Hui et al ( J Clin Invest, 2008,118:3943-53). Oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475778601202eabee60f4ca491c3dd5c
https://doi.org/10.1158/1541-7786.22512190.v1
https://doi.org/10.1158/1541-7786.22512190.v1
Inhibition of hypoxia-induced stress signaling through JNK potentiates the effects of oxaliplatin. The JNK pathway plays a role in both autophagy and apoptosis; therefore, it was determined how much of the effect of JNK inhibition on oxaliplatin sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::162438a105932f81566533b85083eaaf
https://doi.org/10.1158/1541-7786.c.6540160.v1
https://doi.org/10.1158/1541-7786.c.6540160.v1
Autor:
Peter J. O'Dwyer, Jeffrey D. Winkler, Sara R. Goldstein, Lucia Cabal Hierro, Muthu Selvakumaran, Irina A. Vasilevskaya
Supplementary Tables S1-3, Figure S1. Table S1. Hypoxia increases signaling through JNK in colon cancer cell lines in a cell-specific manner Table S2. Hypoxia increases resistance to chemotherapy in colon cancer cell lines Table S3. Combination of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce1336b5542713be659d62789a82c5d
https://doi.org/10.1158/1078-0432.22457534.v1
https://doi.org/10.1158/1078-0432.22457534.v1
Autor:
Peter J. O'Dwyer, Jeffrey D. Winkler, Sara R. Goldstein, Lucia Cabal Hierro, Muthu Selvakumaran, Irina A. Vasilevskaya
Purpose: We showed previously that in HT29 colon cancer cells, modulation of hypoxia-induced stress signaling affects oxaliplatin cytotoxicity. To further study the significance of hypoxia-induced signaling through JNK, we set out to investigate how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426c15ef7c54d9ded421b9b4bcb79603
https://doi.org/10.1158/1078-0432.c.6523610.v1
https://doi.org/10.1158/1078-0432.c.6523610.v1
Data from Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy
Purpose: Autophagy is a critical survival pathway for cancer cells under conditions of nutrient or oxygen limitation, or cell stress. As a consequence of antiangiogenic therapy, solid tumors encounter hypoxia induction and imbalances in nutrient supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2842e91d4093575489c9ab79f43fa534
https://doi.org/10.1158/1078-0432.c.6522138
https://doi.org/10.1158/1078-0432.c.6522138
PDF file - 1198K, We have analyzed autophagy induction in colon cancer cells through TEM and studied the effect of HIF-1 alpha and ATG-5 inhibition in hypoxia-induced autophagy. We have analyzed the synergy between oxaliplatin and CQ on colon cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae2ba2a6acbf04e2bcf10351687444e
https://doi.org/10.1158/1078-0432.22451244
https://doi.org/10.1158/1078-0432.22451244
Publikováno v:
Molecular Cancer Research. 14:753-763
Inhibition of hypoxia-induced stress signaling through JNK potentiates the effects of oxaliplatin. The JNK pathway plays a role in both autophagy and apoptosis; therefore, it was determined how much of the effect of JNK inhibition on oxaliplatin sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04b5f4a4d3aba4e10ea49a23f8144de
https://doi.org/10.1158/1541-7786.mcr-16-0035
https://doi.org/10.1158/1541-7786.mcr-16-0035
Autor:
Jeffrey D. Winkler, Sara R. Goldstein, Irina A. Vasilevskaya, Lucia Cabal Hierro, Peter J. O'Dwyer, Muthu Selvakumaran
Publikováno v:
Clinical Cancer Research. 21:4143-4152
Purpose: We showed previously that in HT29 colon cancer cells, modulation of hypoxia-induced stress signaling affects oxaliplatin cytotoxicity. To further study the significance of hypoxia-induced signaling through JNK, we set out to investigate how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2f84d8a16ac39f5a52f92a98228393
https://doi.org/10.1158/1078-0432.ccr-15-0352
https://doi.org/10.1158/1078-0432.ccr-15-0352
Publikováno v:
Clinical Cancer Research. 19:2995-3007
Purpose: Autophagy is a critical survival pathway for cancer cells under conditions of nutrient or oxygen limitation, or cell stress. As a consequence of antiangiogenic therapy, solid tumors encounter hypoxia induction and imbalances in nutrient supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0248cc5b85a373f280975965a4c6b2
https://doi.org/10.1158/1078-0432.ccr-12-1542
https://doi.org/10.1158/1078-0432.ccr-12-1542
Publikováno v:
Biochemical Pharmacology. 75:627-638
Angiogenesis inhibition has been shown to enhance the therapeutic efficacy of cytotoxic chemotherapy in colorectal cancer. The basis of the contribution of this modality has not been defined fully. To determine the potential role of hypoxia-induced a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc2d2b1a250af75d22309d0edf539d3
https://doi.org/10.1016/j.bcp.2007.09.029
https://doi.org/10.1016/j.bcp.2007.09.029