Zobrazeno 1 - 10
of 1 261
pro vyhledávání: '"Muthu K"'
Autor:
Suresha N. Deveshegowda, Prashant K. Metri, Rashmi Shivakumar, Ji-Rui Yang, Shobith Rangappa, Ananda Swamynayaka, Muthu K. Shanmugam, Omantheswara Nagaraja, Mahendra Madegowda, Priya Babu Shubha, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Kwang Seok Ahn, Peter E. Lobie, Basappa Basappa
Publikováno v:
Molecules, Vol 27, Iss 9, p 2848 (2022)
A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell viability in a human-estrogen-receptor-positive breast cancer cell line. The synthesized c
Externí odkaz:
https://doaj.org/article/835b5bddc7f74e5c85ff91e48605dc4b
Autor:
Dukanya, Muthu K Shanmugam, Shobith Rangappa, Prashant K Metri, Surender Mohan, Basappa, Kanchugarakoppal S Rangappa
Publikováno v:
Data in Brief, Vol 31, Iss , Pp 105979- (2020)
This data in brief article explains the anti-cancer activity and characterization of oxadiazoles [1]. The main objective of this article was to provide general synthetic procedures, spectral discussion and physical data on the new oxadiazole tethered
Externí odkaz:
https://doaj.org/article/c1dbfac0f98c494085f9eaaa9d95960c
Autor:
Chaithanya Somu, Chakrabhavi Dhananjaya Mohan, Sachin Ambekar, Dukanya, Shobith Rangappa, CP Baburajeev, Alexey Sukhorukov, Srishti Mishra, Muthu K Shanmugam, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Basappa, Kanchugarakoppal S. Rangappa
Publikováno v:
Biotechnology Reports, Vol 25, Iss , Pp - (2020)
Constitutive activation of NF-κB is associated with proinflammatory diseases and suppression of the NF-κB signaling pathway has been considered as an effective therapeutic strategy in the treatment of various cancers including hepatocellular carcin
Externí odkaz:
https://doaj.org/article/8e5f088fb9c84db59bc215b3ee91a0f4
Autor:
Muthu K. Shanmugam, Kwang Seok Ahn, Annie Hsu, Chern Chiuh Woo, Yi Yuan, Kwong Huat Benny Tan, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Angele Pei Fern Koh, Frank Arfuso, Ruby Yun-Ju Huang, Lina H. K. Lim, Gautam Sethi, Alan Prem Kumar
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in patients with breast cancer. Therefore, new agents that can abrogate C
Externí odkaz:
https://doaj.org/article/b215012bc4f64c1e873510fa61002aeb
Autor:
Vikas H. Malojirao, Swamy S. Girimanchanaika, Muthu K. Shanmugam, Ankith Sherapura, Dukanya, Prashant K. Metri, Vellingiri Vigneshwaran, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Shobith Rangappa, Chakrabhavi Dhananjaya Mohan, Basappa, Bettadathunga T. Prabhakar, Kanchugarakoppal S. Rangappa
Publikováno v:
Biomedicines, Vol 8, Iss 9, p 368 (2020)
Lung cancer is the leading type of malignancy in terms of occurrence and mortality in the global context. STAT3 is an oncogenic transcription factor that is persistently activated in many types of human malignancies, including lung cancer. In the pre
Externí odkaz:
https://doaj.org/article/2504a6e66d6946f9a80db7cb5307112d
Autor:
Chakrabhavi Dhananjaya Mohan, Hanumantharayappa Bharathkumar, Dukanya, Shobith Rangappa, Muthu K. Shanmugam, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Atanu Bhattacharjee, Peter E. Lobie, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Basappa, Kanchugarakoppal S. Rangappa, Alan Prem Kumar
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the oncogenesis, metastasis, tumor evasion, anti-apoptosis, angiogenesis and proliferation in HCC. Ther
Externí odkaz:
https://doaj.org/article/d5819da4373f47f6b9facf42d97c164c
Autor:
Muthu K. Shanmugam, Kwang S. Ahn, Jong H. Lee, Radhamani Kannaiyan, Nurulhuda Mustafa, Kanjoormana A. Manu, Kodappully S. Siveen, Gautam Sethi, Wee J. Chng, Alan P. Kumar
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Several lines of evidence have demonstrated that deregulated activation of NF-κB plays a pivotal role in the initiation and progression of a variety of cancers including multiple myeloma (MM). Therefore, novel molecules that can effectively suppress
Externí odkaz:
https://doaj.org/article/aa4b91f4db334f2685f95566b11466e8
Autor:
Chakrabhavi Dhananjaya Mohan, Nirvanappa C. Anilkumar, Shobith Rangappa, Muthu K. Shanmugam, Srishti Mishra, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Atanu Bhattacharjee, Gautam Sethi, Alan Prem Kumar, Basappa, Kanchugarakoppal S. Rangappa
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Aberrant activation of NF-κB is linked with the progression of human malignancies including hepatocellular carcinoma (HCC), and blockade of NF-κB signaling could be a potential target in the treatment of several cancers. Therefore, designing of nov
Externí odkaz:
https://doaj.org/article/0940cc58fa724bc39edbfafa5db381bb
Autor:
Muthu K. Shanmugam, Grishma Rane, Madhu Mathi Kanchi, Frank Arfuso, Arunachalam Chinnathambi, M. E. Zayed, Sulaiman Ali Alharbi, Benny K. H. Tan, Alan Prem Kumar, Gautam Sethi
Publikováno v:
Molecules, Vol 20, Iss 2, Pp 2728-2769 (2015)
Despite significant advances in treatment modalities over the last decade, neither the incidence of the disease nor the mortality due to cancer has altered in the last thirty years. Available anti-cancer drugs exhibit limited efficacy, associated wit
Externí odkaz:
https://doaj.org/article/f8091512027144a8977d35bd3b618b00
Autor:
Anilkumar C Nirvanappa, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Hanumappa Ananda, Alexey Yu Sukhorukov, Muthu K Shanmugam, Mahalingam S Sundaram, Siddaiah Chandra Nayaka, Kesturu S Girish, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Gautam Sethi, Basappa, Kanchugarakoppal S Rangappa
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175659 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0163209.].
Externí odkaz:
https://doaj.org/article/76a24ca338674d728121e710c710551d