Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Muthoni Kihiko-Ehmann"'
Publikováno v:
Journal of Neuroscience Research. 70:249-255
Amyloid-beta (Abeta) appears central to Alzheimer's disease (AD), aggregates spontaneously, and is neurotoxic to neurons in vitro. Recently, several groups reported a familial AD locus on chromosome 10. Here, we note that urokinase-type plasminogen a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd2b8878c1fa20f2e813b2404760928
https://doi.org/10.1002/jnr.10417
https://doi.org/10.1002/jnr.10417
Tissue Plasminogen Activator Requires Plasminogen to Modulate Amyloid-β Neurotoxicity and Deposition
Publikováno v:
Journal of Neurochemistry. 75:2172-2177
Tissue plasminogen (plgn) activator (tPA) modulates neuronal death in models of stroke, excitotoxicity, and oxidative stress. Amyloid-beta (Abeta) appears central to Alzheimer's disease and is neurotoxic to neurons in vitro. Here, we evaluate tPA eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e332b6c6989931add5e9ff5b86274f3
https://doi.org/10.1046/j.1471-4159.2000.0752172.x
https://doi.org/10.1046/j.1471-4159.2000.0752172.x
Autor:
Jan St. Pyrek, Atish Mukherjee, Muthoni Kihiko-Ehmann, Louis B. Hersh, Eun-Suk Song, Jack P. Goodman, Steven Estus
Publikováno v:
The Journal of Neuroscience. 20:8745-8749
Insulysin (EC. 3.4.22.11) has been implicated in the clearance of β amyloid peptides through hydrolytic cleavage. To further study the action of insulysin on Aβ peptides recombinant rat insulysin was used. Cleavage of both Aβ1–40and Aβ1–42by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d942041c6154ba142fc8893971eb02
https://doi.org/10.1523/jneurosci.20-23-08745.2000
https://doi.org/10.1523/jneurosci.20-23-08745.2000
Autor:
Muthoni Kihiko-Ehmann, Joseph P. McGillis, James F. Simpson, H. Michael Tucker, Jay L. Degen, Linda H. Younkin, Steven G. Younkin, Steven Estus
Publikováno v:
Neuroscience letters. 368(3)
Deposition of amyloid beta (A beta) into extracellular plaques is a pathologic characteristic of Alzheimer's disease. Plasmin, neprilysin, endothelin-converting enzyme and insulin-degrading enzyme (IDE) have each been implicated in A beta degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf678a18a1632221a75b2abb179808e
https://pubmed.ncbi.nlm.nih.gov/15364412
https://pubmed.ncbi.nlm.nih.gov/15364412