Výsledky vyhledávání - "Muthiah D. Daniel"

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

Autor: Petr O. Ilyinskii, Ronald C. Desrosiers, Andrew A. Lackner, Muthiah D. Daniel, Zhenjian Du, Jae U. Jung, Vito G. Sasseville, Sabine Lang

Publikováno v: Cell. 82(4):665-674

Residues 17 and 18 In nef of SIVmac239 were changed from RQ to YE to create a translated sequence of SRP-SGDLYERLLRARGETYGRLLGEVEDGYSOSP from residues 10–43. The YXXL motifs In this context match very well with consensus sequences for SH2 binding d

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A Comparative Study of Higher Primate Foamy Viruses, Including a New Virus from a Gorilla

Autor: Paul D. Bieniasz, Ian Chrystie, Myra O. McClure, Muthiah D. Daniel, Axel Rethwilm, Richard Pitman

Publikováno v: Virology. 207(1):217-228

Few foamy (spuma) retroviruses have been investigated in molecular detail, despite their previous isolation from several mamalian species, including ten neutralization serotypes from various primates. Here, we have studied a new gorilla foamy virus (

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Reactivity of primate sera to foamy virus Gag and Bet proteins

Autor: Sandra Bräutigam, Gerald Baunach, Axel Rethwilm, Dieter Neumann-Haefelin, Myra O. McClure, Muthiah D. Daniel, Heidi Hahn, Ayalew Mergia

Publikováno v: Journal of General Virology. 75:2635-2644

In order to establish criteria for the Serodiagnosis of foamy virus infections we investigated the extent to which sera from iofected individuals of human and primate origin react with structural and non-structural virus proteins in immunoblot assays

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https://doi.org/10.1099/0022-1317-75-10-2635

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The role of upstream U3 sequences in the pathogenesis of simian immunodeficiency virus-induced AIDS in rhesus monkeys

Autor: Ronald C. Desrosiers, Meredith A. Simon, Andrew A. Lackner, Muthiah D. Daniel, Petr O. Ilyinskii

Publikováno v: Journal of Virology. 68:5933-5944

The nef reading frame overlaps about 70% of the U3 region of the 3' long terminal repeat (LTR) in primate lentiviruses. We investigated the functional role of these overlapping U3 sequences by analyzing the properties of three mutant forms of the pat

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https://doi.org/10.1128/jvi.68.9.5933-5944.1994

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Targeted inhibition of immunodeficiency virus replication in lymphocytes through retroviral mediated gene transfer

Autor: F. Y. T. Tung, Muthiah D. Daniel

Publikováno v: Archives of Virology

Summary To test the feasibility of gene therapy for AIDS patients, an animal model is needed to evaluate the efficacy and safety of this approach. Antiviral genes (encoding antisense RNA or viral protein) derived from Simian immunodeficiency virus (S

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https://doi.org/10.1007/bf01313779

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Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

Autor: Muthiah D. Daniel, Frank Kirchhoff, Ronald C. Desrosiers, Susan Czajak, Prabhat K. Sehgal

Publikováno v: Science. 258:1938-1941

Vaccine protection against the human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in animal models is proving to be a difficult task. The difficulty is due in large part to the persistent, unrelenting nature of HIV

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https://doi.org/10.1126/science.1470917

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Differences in Neutralization of Simian Lentivirus (SIVMAC) in Lymphocyte and Macrophage Cultures

Autor: Michael F. McEntee, M. G. Anderson, Homayoon Farzadegan, Ronald C. Desrosiers, Opendra Narayan, Robert J. Adams, Muthiah D. Daniel

Publikováno v: AIDS Research and Human Retroviruses. 8:1193-1198

Comparison of neutralization of SIVmac251 in primary macrophage cultures with neutralization in lymphocytes (CEM174 cells) showed that neutralizing antibodies induced by SIV251 in infected rhesus macaques protected both macrophages and T lymphocytes

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https://doi.org/10.1089/aid.1992.8.1193

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Induction of AIDS in Rhesus Monkeys by Molecularly Cloned Simian Immunodeficiency Virus

Autor: Douglas J. Ringler, Niels C Pedersen, Marta L. Marthas, Harry W. Kestler, Prabhat K. Sehgal, Andrew A. Lackner, Norval W. King, Toshiaki Kodama, Dean A. Regier, Ronald C. Desrosiers, Muthiah D. Daniel

Publikováno v: Science. 248:1109-1112

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06ca5f40360f0156c0392443167f208
https://doi.org/10.1126/science.2160735

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Use of Simian Immunodeficiency Virus for Vaccine Research

Autor: Cynthia D. Troup, Norval W. King, Michael S. Wyand, Douglas J. Ringler, Toshiaki Kodama, Muthiah D. Daniel, Prabhat K. Sehgal, Ronald C. Desrosiers, D K Schmidt

Publikováno v: Journal of Medical Primatology. 19:395-399

Rhesus monkeys were immunized with purified, disrupted, noninfectious simian immunodeficiency virus (SIV) in adjuvant induced SIV neutralizing antibodies. Two of six previously vaccinated macaques were protected against infection when challenged with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a078aff5c5fdce00013a591b709e721f
https://doi.org/10.1111/j.1600-0684.1990.tb00444.x

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