Zobrazeno 1 - 10
of 785
pro vyhledávání: '"Mutational signature"'
Autor:
Angel Chao, Chen-Yang Huang, Willie Yu, Chiao-Yun Lin, Hao Lin, An-Shine Chao, Cheng-Tao Lin, Hung-Hsueh Chou, Kuang-Gen Huang, Huei-Jean Huang, Ting-Chang Chang, Steven G. Rozen, Ren-Chin Wu, Chyong-Huey Lai
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Ovarian clear cell carcinoma (OCCC) has a disproportionately high incidence among women in East Asia. Patients diagnosed with OCCC tend to experience worse clinical outcomes than those with high-grade serous carcinoma (HGSC) at ad
Externí odkaz:
https://doaj.org/article/cc335f395f114a8e9de10e5412f13877
Autor:
Perihan Hamdy Kassem, Iman Fawzy Montasser, Ramy Mohamed Mahmoud, Rasha Ahmed Ghorab, Dina A. AbdelHakam, Marium EL Sayed Ahmad Fathi, Marwa A. Abdel Wahed, Khaled Mohey, Mariam Ibrahim, Mohamed El Hadidi, Yasmine M. Masssoud, Manar Salah, Arwa Abugable, Mohamad Bahaa, Sherif El Khamisy, Mahmoud El Meteini
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Chronic hepatitis and liver cirrhosis lead to accumulation of genetic alterations driving HCC pathogenesis. This study is designed to explore genomic landscap
Externí odkaz:
https://doaj.org/article/b3b25e70eac842d4ba0e1112865636a9
Autor:
Yi Liu, Sindhu Yalavarthi, Fan Yang, Yusif Abdul-Rashid, Shenkun Tang, Zihe Long, Yongkai Qin, Kerui Wu, Zhifei Wang
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Treatment of non-small lung cancer (NSCLC) has evolved in recent years, benefiting from advances in immunotherapy and targeted therapy. However, limited biomarkers exist to assist clinicians and patients in selecting the most effe
Externí odkaz:
https://doaj.org/article/f63cef02e1224f5c9e56582a00f53780
Autor:
Ahmadreza Niavarani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The APOBEC/AID family is known for its mutator activity, and recent evidence also supports the potential impact of ADARs. Furthermore, the mutator impacts of APOBEC/ADAR mutations have not yet been investigated. Assessment of pancancer TCGA
Externí odkaz:
https://doaj.org/article/2444deb3c12948d2a8b40443da4bcd38
Autor:
Anne-Sophie van der Werf't Lam, Noah C. Helderman, Arnoud Boot, Diantha Terlouw, Hans Morreau, Hailian Mei, Rebecca E.E. Esveldt-van Lange, Inge M.M. Lakeman, Christi J. van Asperen, Emmelien Aten, Nandy Hofland, Pia A.M. de Koning Gans, Emily Rayner, Carli Tops, Niels de Wind, Tom van Wezel, Maartje Nielsen
Publikováno v:
Experimental and Molecular Pathology, Vol 140, Iss , Pp 104940- (2024)
Functional analyses are the main method to classify mismatch repair (MMR) gene variants of uncertain significance (VUSs). However, the pathogenicity remains unclear for many variants because of conflicting results between clinical, molecular, and fun
Externí odkaz:
https://doaj.org/article/495ee08f0dc6450c81f1b9f564d08794
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 3, Pp n/a-n/a (2024)
Abstract Pulmonary spindle cell carcinoma (PSCC) is a rare and aggressive non‐small cell lung cancer (NSCLC) subtype with a dismal prognosis. The molecular characteristics of PSCC are largely unknown due to its rarity, which limits the diagnosis an
Externí odkaz:
https://doaj.org/article/c1f96c018e994adbb7e03a894699b96e
Autor:
Rodrigo D. Drummond, Alexandre Defelicibus, Mathilde Meyenberg, Renan Valieris, Emmanuel Dias-Neto, Rafael A. Rosales, Israel Tojal da Silva
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Cancer is a collection of diseases caused by the deregulation of cell processes, which is triggered by somatic mutations. The search for patterns in somatic mutations, known as mutational signatures, is a growing field of study th
Externí odkaz:
https://doaj.org/article/fe6c58cc23414074a850e822b9241467
Differences in mutational signature of diffuse large B‐cell lymphomas according to the primary organ
Publikováno v:
Cancer Medicine, Vol 12, Iss 19, Pp 19732-19743 (2023)
Abstract Background Comprehensive molecular subtyping of diffuse large B‐cell lymphoma (DLBCL) through genetic profiling has broadened our understanding of DLBCL biology. In this study, we investigated whether DLBCL, not otherwise specified (NOS) s
Externí odkaz:
https://doaj.org/article/3438428077e949d98972b9503e3848c8
Autor:
Yanan Cheng, Dechao Bu, Qiaoling Zhang, Rebecca Sun, Stephen Lyle, Gang Zhao, Li Dong, Hui Li, Yi Zhao, Jinpu Yu, Xishan Hao
Publikováno v:
Journal of Advanced Research, Vol 51, Iss , Pp 121-134 (2023)
Introduction: Gastric cancer (GC)is the third leading cause of cancer-related deaths in China and immunotherapy emerging as a revolutionary treatment for GC recently. Tumor mutational burden (TMB) is a predictive biomarker of immunotherapy in multipl
Externí odkaz:
https://doaj.org/article/8a089f979dcf4158a3517f704a3669a5
Autor:
Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle-Lellbach, Julia Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero, Arnon Gal, Patrick J. Roady, Isabel Pires, Franco Guscetti, John S. Munday, Maria C. Peleteiro, Carlos A. Pinto, Tânia Carvalho, João Cota, Elizabeth C. Du Plessis, Fernando Constantino-Casas, Stephanie Plog, Lars Moe, Simone de Brot, Ingrid Bemelmans, Renée Laufer Amorim, Smitha R. Georgy, Justina Prada, Jorge del Pozo, Marianne Heimann, Louisiane de Carvalho Nunes, Outi Simola, Paolo Pazzi, Johan Steyl, Rodrigo Ubukata, Peter Vajdovich, Simon L. Priestnall, Alejandro Suárez-Bonnet, Franco Roperto, Francesca Millanta, Chiara Palmieri, Ana L. Ortiz, Claudio S. L. Barros, Aldo Gava, Minna E. Söderström, Marie O’Donnell, Robert Klopfleisch, Andrea Manrique-Rincón, Inigo Martincorena, Ingrid Ferreira, Mark J. Arends, Geoffrey A. Wood, David J. Adams, Louise van der Weyden
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-29 (2023)
Abstract Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With a high mutation load and large number of altered genes, strategies to delineate key driver events are necessary. Dogs
Externí odkaz:
https://doaj.org/article/7c66e401481649aaa960de808d382f15