Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Mutation signature"'
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT Oncogenic transformation of normal cells is caused by mutations and chromosomal abnormalities in cancer-related genes. Enzootic bovine leukosis (EBL) is a malignant B-cell lymphoma caused by bovine leukemia virus (BLV) infection in cattle. A
Externí odkaz:
https://doaj.org/article/cf1d4ce1ffdd439996279f1942dc690e
Autor:
Amanda J. Nguyen, MD, Zachary C. Fogarty, MS, Jaime Davila, PhD, Svetomir N. Markovic, MD, PhD, Chen Wang, PhD, Ruifeng Guo, MD, PhD
Publikováno v:
JAAD International, Vol 16, Iss , Pp 189-191 (2024)
Externí odkaz:
https://doaj.org/article/1ed0d3bd581c490aaa7556df85763474
Autor:
Shih-Feng Cho, Tsung-Jang Yeh, Hui-Ching Wang, Jeng-Shiun Du, Yuh-Ching Gau, Yu-Yin Lin, Tzer-Ming Chuang, Yi-Chang Liu, Hui-Hua Hsiao, Sin-Hua Moi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The present study aimed to elucidate the prognostic mutation signature (PMS) associated with long-term survival in a diffuse large B-cell lymphoma (DLBCL) cohort. All data including derivation and validation cohorts were retrospectively retr
Externí odkaz:
https://doaj.org/article/01981a3d3977420b94a7b8a4709014ae
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background There is an unmet need to identify novel predictive biomarkers that enable more accurate identification of individuals who can benefit from immune checkpoint inhibitor (ICI) therapy. The US FDA recently approved tumor mutational b
Externí odkaz:
https://doaj.org/article/95e30b8c4d814668abf39bcbcfa0a7fb
Publikováno v:
Journal of Hepatocellular Carcinoma, Vol Volume 10, Pp 241-255 (2023)
Yuyuan Zhang,1,* Zaoqu Liu,1,* Jie Li,1 Xin Li,1 Mengjie Duo,2 Siyuan Weng,1 Peijie Lv,3 Guozhong Jiang,4 Caihong Wang,5 Yan Li,6 Shichao Liu,6 Zhen Li1 1Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou Unive
Externí odkaz:
https://doaj.org/article/2b9eade8ce9b403c80f88bd1a10a2f96
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2536-2546 (2023)
Immune checkpoint inhibitor (ICI) therapy has become a powerful clinical strategy for treating melanoma. The relationship between somatic mutations and the clinical benefits of immunotherapy has been widely recognized. However, the gene-based predict
Externí odkaz:
https://doaj.org/article/355516204b3e465fbd86c5bd0794ff3e
Autor:
Hiroko Natsume, Kinga Szczepaniak, Hidetaka Yamada, Yuji Iwashita, Marta Gędek, Jelena Šuto, Keiko Ishino, Rika Kasajima, Tomonari Matsuda, Felix Manirakiza, Augustin Nzitakera, Yijia Wu, Nong Xiao, Qiong He, Wenwen Guo, Zhenming Cai, Tsutomu Ohta, Tıberiu Szekely, Zoltan Kadar, Akiko Sekiyama, Takashi Oshima, Takaki Yoshikawa, Akira Tsuburaya, Nobuhito Kurono, Yaping Wang, Yohei Miyagi, Simona Gurzu, Haruhiko Sugimura
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-13 (2023)
Abstract Aim Mutation spectrum of TP53 in gastric cancer (GC) has been investigated world-widely, but a comparison of mutation spectrum among GCs from various regions in the world are still sparsely documented. In order to identify the difference of
Externí odkaz:
https://doaj.org/article/cbf4ee58a8bd45a5ab90f396841a9a36
Akademický článek
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Akademický článek
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Autor:
Danielle P. M. LeBlanc, Matthew Meier, Fang Yin Lo, Elizabeth Schmidt, Charles Valentine, Andrew Williams, Jesse J. Salk, Carole L. Yauk, Francesco Marchetti
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Exposure to environmental mutagens increases the risk of cancer and genetic disorders. We used Duplex Sequencing (DS), a high-accuracy error-corrected sequencing technology, to analyze mutation induction across twenty 2.4 kb intergenic and g
Externí odkaz:
https://doaj.org/article/de787e54ba8b4487a1cb44641888716a