A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease

Autor: Kai-Po Chen, Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I. Yang, Hsien-Ta Hsu, Tz-Chuen Ju

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)

Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG repeats exceeds 36, the translated expanded polyglutamine-containing HTT pr

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Protective Effects of Antcin H Isolated from Antrodia cinnamomea Against Neuroinflammation in Huntington's Disease via NLRP3 Inflammasome Inhibition.

Autor: Chang YJ; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan., Chen CH; Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D. Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Life Science, Tunghai University, Taichung, Taiwan., Chen YC; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan., Wu MT; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan.; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Lin TY; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan.; Institute of Molecular Biology, National Chung Hsing University, No. 145 Xingda Rd., South Dist., Taichung, 402202, Taiwan., Hua KF; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan., Ju TC; Institute of Molecular Biology, National Chung Hsing University, No. 145 Xingda Rd., South Dist., Taichung, 402202, Taiwan. tcju@dragon.nchu.edu.tw.; Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan. tcju@dragon.nchu.edu.tw.

Publikováno v: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2024 Dec 02; Vol. 20 (1), pp. 1. Date of Electronic Publication: 2024 Dec 02.