Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mutant Proteins/metabolism"'
Autor:
Jan Maarten van Dijl, Margarita Bernal-Cabas, Marina López-Álvarez, Uwe Völker, Leif Steil, Ulrike Mäder, Marc Schaffer, Hermann Rath, Bimal Prajapati, Jürgen Bartel, Dörte Becher
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research, 1868(2). ELSEVIER SCIENCE BV
Biochim Biophys Acta Mol Cell Res
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1868(2):118914. ELSEVIER SCIENCE BV
Biochim Biophys Acta Mol Cell Res
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1868(2):118914. ELSEVIER SCIENCE BV
The widely conserved twin-arginine translocases (Tat) allow the transport of fully folded cofactor-containing proteins across biological membranes. In doing so, these translocases serve different biological functions ranging from energy conversion to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5c8d6d6d27e150611f1c3e48c911e5
https://research.rug.nl/en/publications/dad5bca9-799d-4cd5-9e17-b66e40402bde
https://research.rug.nl/en/publications/dad5bca9-799d-4cd5-9e17-b66e40402bde
Autor:
Veronica Aedo-Lopez, Bettina Bisig, Alexandre Wicky, Olivier Michielin, Mounir Trimech, Camille L. Gerard, Fanny S Krebs, Krisztian Homicsko, Edoardo Missiaglia, Vincent Zoete
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8021, p 8021 (2020)
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 21, pp. E8021
Volume 21
Issue 21
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 21, pp. E8021
Volume 21
Issue 21
We report a case of an uveal melanoma patient with GNAQ p.Gly48Leu who responded to MEK inhibition. At the time of the molecular analysis, the pathogenicity of the mutation was unknown. A tridimensional structural analysis showed that G&alpha
q
q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720d088a79814508b85a7b35f96730d
https://www.mdpi.com/1422-0067/21/21/8021
https://www.mdpi.com/1422-0067/21/21/8021
Autor:
Stéphanie Miserey-Lenkei, Patricia Bassereau, Feng-Ching Tsai, Laura Picas, Yosuke Senju, Aurélie Bertin, Emmanuel Lemichez, Pekka Lappalainen, John Manzi, Evelyne Coudrier, Hugo Bousquet, Meng Chen Tsai
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife, 2018, 7, pp.e37262. ⟨10.7554/eLife.37262⟩
eLife, eLife Sciences Publication, 2018, 7, pp.e37262. ⟨10.7554/eLife.37262⟩
eLife
eLife, 2018, 7, pp.e37262. ⟨10.7554/eLife.37262⟩
eLife, eLife Sciences Publication, 2018, 7, pp.e37262. ⟨10.7554/eLife.37262⟩
One challenge in current cell biology is to decipher the biophysical mechanisms governing protein enrichment on curved membranes and the resulting membrane deformation. The ERM protein ezrin is abundant and associated with cellular membranes that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bed8206767b2be9e516c247ec498bb
https://elifesciences.org/articles/37262
https://elifesciences.org/articles/37262
Autor:
Bourges, Anais C., Montaguth, Oscar E. Torres, Ghosh, Anirban, Tadesse, Wubishet M., Declerck, Nathalie, Aertsen, Abram, Royer, Catherine A.
Publikováno v:
Nucleic Acids Research
Bourges, A C, Torres Montaguth, O E, Ghosh, A, Tadesse, W M, Declerck, N, Aertsen, A & Royer, C A 2017, ' High pressure activation of the Mrr restriction endonuclease in Escherichia coli involves tetramer dissociation ', Nucleic Acids Research, vol. 45, no. 9, pp. 5323-5332 . https://doi.org/10.1093/nar/gkx192
Nucleic Acids Research, Oxford University Press, 2017, 45 (9), pp.5323-5332. ⟨10.1093/nar/gkx192⟩
Bourges, A C, Torres Montaguth, O E, Ghosh, A, Tadesse, W M, Declerck, N, Aertsen, A & Royer, C A 2017, ' High pressure activation of the Mrr restriction endonuclease in Escherichia coli involves tetramer dissociation ', Nucleic Acids Research, vol. 45, no. 9, pp. 5323-5332 . https://doi.org/10.1093/nar/gkx192
Nucleic Acids Research, Oxford University Press, 2017, 45 (9), pp.5323-5332. ⟨10.1093/nar/gkx192⟩
A sub-lethal hydrostatic pressure (HP) shock of ∼100 MPa elicits a RecA-dependent DNA damage (SOS) response in Escherichia coli K-12, despite the fact that pressure cannot compromise the covalent integrity of DNA. Prior screens for HP resistance id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3cf031e198981efdaab6ed934e0f24a2
https://pubmed.ncbi.nlm.nih.gov/28369499
https://pubmed.ncbi.nlm.nih.gov/28369499
Autor:
Carolina Uggenti, Kit Briant, Anne-Kathrin Streit, Steven Thomson, Yee Hui Koay, Richard A. Baines, Eileithyia Swanton, Forbes D. Manson
Publikováno v:
Uggenti, C, Briant, K, Streit, A-K, Thomson, S, Koay, Y H, Baines, R A, Swanton, E & Manson, F D 2016, ' Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model ', Disease Models and Mechanisms, vol. 9, no. 11, pp. 1317-1328 . https://doi.org/10.1242/dmm.024216
Disease Models & Mechanisms
Uggenti, C, Briant, K, Streit, A-K, Thomson, S, Koay, Y H, Baines, R, Swanton, L & Manson, F D 2016, ' Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model ', DMM Disease Models and Mechanisms, vol. 9, no. 11, pp. 1317-1328 . https://doi.org/10.1242/dmm.024216
Disease Models & Mechanisms, Vol 9, Iss 11, Pp 1317-1328 (2016)
Disease Models & Mechanisms
Uggenti, C, Briant, K, Streit, A-K, Thomson, S, Koay, Y H, Baines, R, Swanton, L & Manson, F D 2016, ' Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model ', DMM Disease Models and Mechanisms, vol. 9, no. 11, pp. 1317-1328 . https://doi.org/10.1242/dmm.024216
Disease Models & Mechanisms, Vol 9, Iss 11, Pp 1317-1328 (2016)
Autosomal recessive bestrophinopathy (ARB) is a retinopathy caused by mutations in the bestrophin-1 protein, which is thought to function as a Ca2+-gated Cl− channel in the basolateral surface of the retinal pigment epithelium (RPE). Using a stably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::239865a4b1663d966fc5181c997e1a95
https://hdl.handle.net/20.500.11820/1cb41380-f9f4-4178-bead-830af72f8a24
https://hdl.handle.net/20.500.11820/1cb41380-f9f4-4178-bead-830af72f8a24
Autor:
Doreen A. Cantrell, April P. Kelly, Rosie G Clarke, Freddy Radtke, David K. Finlay, Emma Fiorini, Heather J. Hinton
Publikováno v:
The EMBO Journal
EMBO Journal, vol. 26, no. 14, pp. 3441-50
EMBO Journal, vol. 26, no. 14, pp. 3441-50
Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte differentiation and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e816e7f2b15d2072115b92bc8fa24df3
https://doi.org/10.1038/sj.emboj.7601761
https://doi.org/10.1038/sj.emboj.7601761
Autor:
Romy Kronstein, Hans-Joachim Schnittler, Carsten Minten, Abdallah Abu Taha, Yvan Arsenijevic, Tatiana Afanasieva, Marek Drab, Jochen Seebach, Stefan Liebner, Sylvia Grossklaus, Britta Engelhardt
Publikováno v:
Cardiovascular Research, vol. 93, no. 1, pp. 130-140
Kronstein, Romy; Seebach, Jochen; Grossklaus, Sylvia; Minten, Carsten; Engelhardt, Britta; Drab, Marek; Liebner, Stefan; Arsenijevic, Yvan; Taha, Abdallah Abu; Afanasieva, Tatiana; Schnittler, Hans-Joachim (2012). Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovascular research, 93(1), pp. 130-40. Oxford: Oxford University Press 10.1093/cvr/cvr256
Kronstein, Romy; Seebach, Jochen; Grossklaus, Sylvia; Minten, Carsten; Engelhardt, Britta; Drab, Marek; Liebner, Stefan; Arsenijevic, Yvan; Taha, Abdallah Abu; Afanasieva, Tatiana; Schnittler, Hans-Joachim (2012). Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovascular research, 93(1), pp. 130-40. Oxford: Oxford University Press 10.1093/cvr/cvr256
AIMS: A fundamental phenomenon in inflammation is the loss of endothelial barrier function, in which the opening of endothelial cell junctions plays a central role. However, the molecular mechanisms that ultimately open the cell junctions are largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5659795732fad4950547b7c085aac6be
https://serval.unil.ch/notice/serval:BIB_CCF339084AD6
https://serval.unil.ch/notice/serval:BIB_CCF339084AD6
Autor:
Stephen M. Fuchs, Shana C. Kerr, Nowel Azzouz, R. Nicholas Laribee, Martine A. Collart, Anita H. Corbett, Brian D. Strahl
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18302 (2011)
PloS one
PLoS ONE
PLOS ONE, Vol. 6, No 3 (2011) P. e18302
PloS one
PLoS ONE
PLOS ONE, Vol. 6, No 3 (2011) P. e18302
Background The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858570faf380f2466ec05ae2b262f026
http://europepmc.org/articles/PMC3065485?pdf=render
http://europepmc.org/articles/PMC3065485?pdf=render
Autor:
Laure Willen, Sylvia A. Frazier-Bowers, Gabriele Mues, Hitesh Kapadia, Rena N. D'Souza, Pascal Schneider, Aubry Tardivel, Robyn Seaman
Publikováno v:
Eur J Hum Genetics
European Journal of Human Genetics, vol. 18, no. 1, pp. 19-25
European Journal of Human Genetics, vol. 18, no. 1, pp. 19-25
Mutations of the Ectodysplasin-A (EDA) gene are generally associated with the syndrome hypohidrotic ectodermal dysplasia (MIM 305100), but they can also manifest as selective, non-syndromic tooth agenesis (MIM300606). We have performed an in vitro fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a21bcc7915207bf7eb1c97d86656e1
Publikováno v:
Science, Vol. 325, No 5941 (2009) pp. 753-756
Jamming Protein Translocation Antibiotics are tremendously important drugs in modern medicine, yet we are still learning precisely how they work. SecY is a bacterial membrane protein that is part of a complex that allows protein secretion across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffecee15bb15292da7e86855a7119324
https://pubmed.ncbi.nlm.nih.gov/19661407
https://pubmed.ncbi.nlm.nih.gov/19661407