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Protein Quality Control Pathways at the Crossroad of Synucleinopathies

Autor: Anne S. Wentink, Eduardo Preusser de Mattos, Carmen Nussbaum-Krammer, Steven Bergink, Ronald Melki, Harm H. Kampinga, Christian Hansen

Publikováno v: Journal of Parkinson's disease
Journal of Parkinson's disease, Amsterdam : b : IOS Press, In press, 14 pp. ⟨10.3233/JPD-191790⟩
Journal of Parkinson's Disease
Journal of Parkinson's disease, In press, 14 pp. ⟨10.3233/JPD-191790⟩

International audience; The pathophysiology of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and many others converge at alpha-synuclein ($\alpha$-Syn) aggregation. Although it is still not entirely clear what precise bioph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac22422a0a8156bc7855538e08f8929
https://hal-cea.archives-ouvertes.fr/cea-02458907

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Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease

Autor: Lahut, Suna, Gispert, Suzana, Ömür, Özgür, Depboylu, Candan, Seidel, Kay, Domínguez-Bautista, Jorge Antolio, Brehm, Nadine, Tireli, Hülya, Hackmann, Karl, Pirkevi, Caroline, Leube, Barbara, Ries, Vincent, Reim, Kerstin, Brose, Nils, den Dunnen, Wilfred F., Johnson, Madrid, Wolf, Zsuzsanna, Schindewolf, Marc, Schrempf, Wiebke, Reetz, Kathrin, Young, Peter, Vadasz, David, Frangakis, Achilleas S., Schröck, Evelin, Steinmetz, Helmuth, Jendrach, Marina, Rüb, Udo, Başak, Ayşe Nazlı, Oertel, Wolfgang, Auburger, Georg

Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 5, Pp 619-631 (2017)
Disease models & mechanisms, 10(5), 619-631. COMPANY OF BIOLOGISTS LTD
Disease models & mechanisms 10(5), 619-631 (2017). doi:10.1242/dmm.028035
Disease Models & Mechanisms

Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component α-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00a153c63c1d424b377819a4e97cc4e